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中国药学(英文版)

• 【研究论文】 • 上一篇    下一篇

羊踯躅的化学成分研究

王璇, 胡艳维, 袁丹*, 付宏征*   

  1. 1. 沈阳药科大学 中药学院, 辽宁 沈阳 110016
    2. 北京大学医学部 天然药物及仿生药物国家重点实验室, 北京 100191 
  • 收稿日期:2013-05-03 修回日期:2013-05-27 出版日期:2014-02-15 发布日期:2014-01-25
  • 通讯作者: 袁丹*, 付宏征*
  • 作者简介:*Corresponding author. Tel./Fax: 86-10-82805212; E-mail: drhzfu@sina.com
  • 基金资助:
    National Natural Science Foundation of China (Grant No. 81172943).

Chemical constituents from the flowers of Rhododendron molle G. Don

Xuan Wang, Yanwei Hu, Dan Yuan*, Hongzheng Fu*   

  1. 1. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
  • Received:2013-05-03 Revised:2013-05-27 Online:2014-02-15 Published:2014-01-25
  • Contact: Dan Yuan*, Hongzheng Fu*
  • About author:*Corresponding author. Tel./Fax: 86-10-82805212; E-mail: drhzfu@sina.com
  • Supported by:
    National Natural Science Foundation of China (Grant No. 81172943).

摘要:

对羊踯躅植物花蕾的化学成分进行研究, 应用多种色谱技术进行分离纯化、波谱技术鉴定其结构。从羊踯躅花蕾中分离并鉴定了15个化合物, 分别为2E, 4Z-脱落酸 (1), 2α-羟基齐墩果酸 (2), 齐墩果酸 (3), 积雪草酸 (4), 苯甲基糖苷 (5), 邻苯二甲酸二丁酯 (6), β-谷甾醇 (7), 牡荆素 (8), 槲皮素 (9), 硬脂酸 (10), rhodomollein I (11), rhodojaponin VI (12), rhodomollein XI (13), rhodojaponin II (14), kalmanol (15)。其中, 化合物110为首次从羊踯躅植物中得到。

关键词: 羊踯躅, 化学成分, 结构鉴定

Abstract:

The aim of current study was to investigate the chemical constituents from the flowers of Rhododendron molleG. Don. The isolation and purification of components were achieved by a series of chromatography including silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were identified based on 1D, 2D NMR, and mass spectral analysis. Fifteen known compounds were isolated and their structures were identified as 2E,4Z-abscisic acid (1), 2α-hydroxy-oleanolic acid (2), oleanic acid (3), asiatic acid (4), benzyl glucoside (5), dibutyl phthalate (6), β-sitosterol (7), vitexin (8), quercetin (9), steraric acid (10), rhodomollein I (11), rhodojaponin VI (12), rhodomollein XI (13), rhodojaponin II (14), kalmanol (15). Compounds 110 were isolated from Rhododendron molle for the first time.

Key words: Rhododendron molle, Chemical constituents, Structural identification

中图分类号: 

Supporting: National Natural Science Foundation of China (Grant No. 81172943).