南海小月柳珊瑚中倍半萜类化学成分研究

doi:10.5246/jcps.2013.03.041

南海小月柳珊瑚中倍半萜类化学成分研究

郭志琴, 柴兴云, 杨斌, 周雪峰, 刘永宏^*, 屠鹏飞^*

1. 北京中医药大学中药现代研究中心, 北京 100029
2. 中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室, 广东广州 510301
3. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2012-10-11 修回日期:2013-02-20 出版日期:2013-05-08 发布日期:2013-05-08
通讯作者: 刘永宏*, 屠鹏飞*

Sesquiterpenoids from a South China Sea gorgonian Menella sp.

Zhiqin Guo, Xingyun Chai, Bin Yang, Xuefeng Zhou, Yonghong Liu^*, Pengfei Tu^*

1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China

Received:2012-10-11 Revised:2013-02-20 Online:2013-05-08 Published:2013-05-08
Contact: Yonghong Liu*, Pengfei Tu*

摘要/Abstract

摘要： 对南海小月柳珊瑚Menella sp. 的化学成分进行研究。应用反复硅胶柱层析、Sephadex LH20柱色谱和制备薄层等多种色谱方法进行分离和纯化。从中分离得到3个subergorane倍半萜和1个suberosane倍半萜化合物, 利用波谱分析技术和文献比对等方法确定化合物的结构, 分别为柳珊瑚酸 (1), 柳珊瑚酸甲酯 (2), 2β-羟基柳珊瑚酸甲酯 (3) 和suberosenol A (4)。以上化合物均为首次从小月柳珊瑚属 (Menella) 中分离得到。

关键词: 柳珊瑚, 小月柳珊瑚, 倍半萜, 丛柳珊瑚科

Abstract: To investigate the chemical constituents of a South China Sea gorgonian Menella sp., the isolation of ingredients was performed by solvent extraction and repeated chromatography on silica gel, Sephadex LH20 and preparative TLC. The structures of isolated compounds were determined by spectroscopic analysis and comparison of ¹H and ¹³C NMR data with those reported in literatures. Three subergorane sesquiterpenoids and one suberosane sesquiterpenoid were isolated. Their structures were identified as subergorgic acid (1), subergorgic acid methyl ester (2), 2β-hydroxyl subergorgic acid methyl ester (3), and suberosenol A (4). All compounds were isolated from the genus Menella for the first time.

Key words: Gorgonian, Menella sp., Sesquiterpenoid, Plexauridae

中图分类号:

R284

Supporting: Foundation items: Post-doctoral Science Foundation of China (Grant No. 20080440784) and Guangdong Province Natural Science Foundation (Grant No. 9451030101003549).
^*Corresponding author. Tel.: 86-10-82802750

郭志琴, 柴兴云, 杨斌, 周雪峰, 刘永宏^*, 屠鹏飞^*. 南海小月柳珊瑚中倍半萜类化学成分研究[J]. , DOI: 10.5246/jcps.2013.03.041.

Zhiqin Guo, Xingyun Chai, Bin Yang, Xuefeng Zhou, Yonghong Liu^*, Pengfei Tu^* . Sesquiterpenoids from a South China Sea gorgonian Menella sp. [J]. , DOI: 10.5246/jcps.2013.03.041.

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