金丝桃属植物中的金丝桃素: 化学、植物来源和生物活性

doi:10.5246/jcps.2012.05.052

摘要/Abstract

摘要： 金丝桃素是金丝桃属植物中一种重要的次生代谢产物, 1830年首次被正式报道, 它是一种天然光敏型的二蒽酮类化合物。金丝桃素具有抗病毒, 抗抑郁、抗肿瘤、抗菌、抗氧化等广泛的生物和药理活性, 并用于光动力治疗。在过去的几十年中越来越多的证据表明金丝桃素具有很大的药用潜力和临床价值。本篇综述了金丝桃素的化学、植物来源和生物活性。

关键词: 金丝桃素, 植物来源, 化学, 生物活性

Abstract:

Hypericin, a secondary metabolite first reported in 1830, is a natural photosensitizing naphtodianthrone and is mainly from the natural plant sources of genus Hypericum. Hypericin exhibits a wide variety of biological and pharmacological activities, such as antiviral, antidepressant, antitumor, antimicrobial, and antioxidant activity. Hypericin can also be utilized in photodynamic diagnosis. Accumulating evidence is pointing to the effects of hypericin with potential pharmaceutical and clinical interests in the past decades. The present review gives a comprehensive outline of the chemistry, botanical occurrence and biological activities of this powerful compound.

Key words: Hypericin, Botanical sources, Chemistry, Biological activities

中图分类号:

R282.6

Supporting:

Foundation items: Key National Natural Science Foundation of China (Grant No. 81130069), Selected Program of Personnel Department for Oversea Scholar (2009-2011); the Chinese National S&T Special Project on Major New Drug Innovation (Grant No. 2011ZX09307-002-01); the Key Technologies of the Quality Standards and the Safety of Health Food, "863 Program" (Grant No. 2010AA023006).
^*Corresponding author. Tel./Fax: 86-10-57833197; 15801545922

黄林芳, 陈士林^*. 金丝桃属植物中的金丝桃素: 化学、植物来源和生物活性[J]. , DOI: 10.5246/jcps.2012.05.052.

Linfang Huang, Shilin Chen^*. Hypericin in hypericum: chemistry, botanical sources and biological activities[J]. , DOI: 10.5246/jcps.2012.05.052.

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