中国南海丰肉结海绵相关丛赤壳属真菌HLS206代谢产物研究

doi:10.5246/jcps.2012.02.024

中国南海丰肉结海绵相关丛赤壳属真菌HLS206代谢产物研究

王瑞杉, 巩婷, 朱平^*, 程克棣

中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室; 卫生部天然药物生物合成重点实验室, 北京 100050

收稿日期:2011-07-14 修回日期:2011-12-01 出版日期:2012-03-15 发布日期:2012-03-15
通讯作者: 朱平*

Isolation of metabolic products from the fungus Nectria sp. HLS206 that is associated with the marine sponge Gelliodes carnosa collected from the South China Sea

Rui-Shan Wang, Ting Gong, Ping Zhu^*, Ke-Di Cheng

State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received:2011-07-14 Revised:2011-12-01 Online:2012-03-15 Published:2012-03-15
Contact: Ping Zhu*

摘要/Abstract

摘要： 海绵相关真菌丛赤壳属HLS206系肉座菌目真菌, 分离自我国南海丰肉结海绵。本文对HLS206进行了次生代谢产物研究, 通过发酵培养分离得到5个化合物, 并应用质谱及一维和二维核磁共振 (COSY, HMQC和HMBC) 等方法进行结构鉴定, 分别确定为chalmicrin (1)、hypocrealesate (2)、岩藻甾醇 (3)、豆甾醇 (4)和β-谷甾醇 (5)。化合物1为首次从肉座菌目真菌中分离获得; 化合物2的有关波谱数据为首次报道。

关键词: 海绵相关真菌, 丛赤壳属, 次生代谢产物, 波谱数据

Abstract: The sponge-associated fungus Nectria sp. HLS206, which belongs to the order of Hypocreales, was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea. The secondary metabolites of the fungus were isolated. From the solid cultures, five compounds were purified, which are chalmicrin (1), hypocrealesate (2), fucosterol (3), stigmasterol (4) and β-sitosterol (5). The structures of the 5 compounds were elucidated by ESI-MS, 1D and 2D NMR spectra (COSY, HMQC and HMBC). To the best of our knowledge, it is the first time compound 1 was isolated from the order of Hypocreales, and the spectral data of compound 2 are also firstly reported.

Key words: Sponge-associated fungus, Nectria sp., Secondary metabolites, Spectral data

中图分类号:

R284.2

Supporting:

Foundation item: National Science and Technology Project of China (Grant No. 2009ZX09301-003-4-1).
^*Corresponding author. Tel.: 86-10-63165197

王瑞杉, 巩婷, 朱平^*, 程克棣. 中国南海丰肉结海绵相关丛赤壳属真菌HLS206代谢产物研究[J]. , DOI: 10.5246/jcps.2012.02.024.

Rui-Shan Wang, Ting Gong, Ping Zhu^*, Ke-Di Cheng. Isolation of metabolic products from the fungus Nectria sp. HLS206 that is associated with the marine sponge Gelliodes carnosa collected from the South China Sea [J]. , DOI: 10.5246/jcps.2012.02.024.

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