制马钱子的化学成分研究

doi:10.5246/jcps.2012.02.025

制马钱子的化学成分研究

张加余, 李宁, 胡姱, 屠鹏飞^*

北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2011-12-01 修回日期:2012-02-02 出版日期:2012-03-15 发布日期:2012-03-15
通讯作者: 屠鹏飞*

Chemical constituents from processed seeds of Strychnos nux-vomica

Jia-Yu Zhang, Ning Li, Kua Hu, Peng-Fei Tu^*

State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China

Received:2011-12-01 Revised:2012-02-02 Online:2012-03-15 Published:2012-03-15
Contact: Peng-Fei Tu*

摘要/Abstract

摘要：

从制马钱子中分离并鉴定了15个化合物, 分别为番木鳖碱 (1), 马钱子碱 (2), 伪番木鳖碱 (3), 伪马钱子碱 (4), 裂环马钱素酸 (5), 咖啡酸 (6), 对羟基苯甲酸 (7), 对羟基苯乙酸 (8), 熊果醇 (9), 7,22,25-豆甾三烯-3-醇 (10), 羽扇豆醇 (11), 11-酮基-香树脂棕榈酸酯 (12), 儿茶酚 (13), 麦芽酚 (14), 腺苷 (15)。化合物5-15为首次从马钱属植物中分离得到。

关键词: 制马钱子, 化学成分, 结构鉴定,

Abstract:

Fifteen compounds were isolated from the processed seeds of Strychnos nux-vomica and were identified as follows: strychnine (1), brucine (2), pseudostrychnine (3), pseudobrucine (4), secoxyloganin (5), caffeic acid (6), p-hydroxybenzoic acid (7), p-hydroxyphenylacetic acid (8), uvaol (9), stigmasta-7,22,25-triene-3-ol (10), lupeol (11), 11-oxo-α-amyrin palmitate (12), catechol (13), maltol (14), adenosine (15). Compounds 5-15 were isolated from genus Strychnos for the first time.

Key words: Processed seeds of Strychnos nux-vomica, Chemical constituents, Structural identification

中图分类号:

R282.5

Supporting:

Foundation items: Research Platform for Quality Standard of TCM and Information System Building (Grant No. 2009ZX09308-04) and National S&T Major Project-Created Major New Drugs Projects (Grant No. 2009ZX09311-004).
^*Corresponding author. Tel.: 86-10-82802750

张加余, 李宁, 胡姱, 屠鹏飞^*. 制马钱子的化学成分研究[J]. , DOI: 10.5246/jcps.2012.02.025.

Jia-Yu Zhang, Ning Li, Kua Hu, Peng-Fei Tu^*. Chemical constituents from processed seeds of Strychnos nux-vomica [J]. , DOI: 10.5246/jcps.2012.02.025.

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