爪哇脚骨脆中三萜类化学成分研究

doi:10.5246/jcps.2012.03.036

爪哇脚骨脆中三萜类化学成分研究

李飞飞, 郭志琴, 柴兴云, 屠鹏飞^*

1. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
2. 北京中医药大学中药现代研究中心, 北京 100029

收稿日期:2012-01-09 修回日期:2012-03-25 出版日期:2012-05-15 发布日期:2012-05-15
通讯作者: 屠鹏飞*

Triterpenoids from the stems of Casearia velutina Bl.

Fei-Fei Li, Zhi-Qin Guo, Xing-Yun Chai, Peng-Fei Tu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2012-01-09 Revised:2012-03-25 Online:2012-05-15 Published:2012-05-15
Contact: Peng-Fei Tu*

摘要/Abstract

摘要：

从大风子科植物爪哇脚骨脆的树干中分离得到11个已知三萜类化合物, 经波谱解析及与文献对照方法, 分别鉴定为木栓酮-2,3-内酯 (1), 木栓烷 (2), 表木栓醇 (3), 木栓酮 (4), 2α,3α,19α-三羟基-乌苏烷-12-烯-28-羧酸 (5), 2α,3β,19α-三羟基-乌苏烷-12-烯-28-羧酸 (6), 2α,3α,23-三羟基-乌苏烷-12-烯-28-羧酸 (7), 2α,3α,23-三羟基-齐墩果烷-12-烯-28-羧酸 (8), 2α,3α,19α,23-四羟基-乌苏烷-12-烯-28-羧酸 (9), 2α,3α,19α,23-四羟基-乌苏烷-12-烯-28-羧酸-28-O-β-D-葡萄糖酯 (10), 及3β,19α-双羟基-乌苏烷-12-烯-28-羧酸3-O-α-L-阿拉伯糖苷 (11). 其中化合物1为大风子科植物中稀有的裂环木栓烷三萜, 所有化合物皆为首次从本植物中分离得到。

关键词: 爪哇脚骨脆, 大风子科, 三萜, 化学成分

Abstract:

To investigate the chemical components from the stems of Casearia velutina Bl., the constituents were isolated by repeated chromatography with silica gel, Sephadex LH-20, and ODS columns. The structures were elucidated by spectroscopic analysis. Eleven triterpenoids and its glycosides were isolated from the crude extract of C. velutina, and their structures were identified as friedelin-2,3-lactone (1), friedelane (2), epifriedelanol (3), friedelin (4), 2α,3α,19α-trihydroxy-urs-12-en-28-oic acid (5), 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid (6), 2α,3α,23-trihydroxy-urs-12-en-28-oic acid (7), 2α,3α,23-trihydroxy-olean-12-en-28-oic acid (8), 2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oic acid (9), 2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oic acid-28-O-β-D-glucopyranosyl ester (10), and 3β,19α-dihydroxy-urs-12-en-28-oic acid 3-O-α-L-arabinopyranoside (11). All the compounds described above were isolated from this species for the first time. Compound 1 is a rarely occurred seco-friedelolactone in Flacourtiaceae.

Key words: Casearia velutina Bl., Flacourtiaceae, Triterpenoid, Chemical constituents

中图分类号:

R284.1

Supporting:

Foundation item: Changjiang Scholar and Innovative Team in University (Grant No. 985-2-063-112).
*Corresponding author. Tel.: 86-10-82802750

李飞飞, 郭志琴, 柴兴云, 屠鹏飞^*. 爪哇脚骨脆中三萜类化学成分研究[J]. , DOI: 10.5246/jcps.2012.03.036.

Fei-Fei Li, Zhi-Qin Guo, Xing-Yun Chai, Peng-Fei Tu^*. Triterpenoids from the stems of Casearia velutina Bl.[J]. , DOI: 10.5246/jcps.2012.03.036.

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