中国仿制药替代影响因素分析——基于

doi:10.5246/jcps.2023.04.028

中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (4): 317-321.DOI: 10.5246/jcps.2023.04.028

• 【药事管理与临床药学专栏】 • 上一篇下一篇

中国仿制药替代影响因素分析——基于"4 + 7"带量采购精神科用药患者角度

刘文夏¹, 马俊², 杨照³^,^*(), 江滨¹^,^*()

1. 北京大学医学部药学院药事管理与临床药学系, 北京 100191
2. 北京大学第三医院, 北京 100091
3. 北京大学第一医院科研处, 北京 100034

收稿日期:2022-10-23 修回日期:2022-12-26 接受日期:2023-01-08 出版日期:2023-04-29 发布日期:2023-04-29
通讯作者: 杨照, 江滨
作者简介:
+ Tel.: +86-13601100121, E-mail: binjiang@bjmu.edu.cn
+ Tel.: +86-15210596561, E-mail: 15210596561@163.com
基金资助:
Beijing Natural Science Foundation (Grant No. 9224039).

Influencing factors of generic drug substitution in China—from the perspective of psychiatric patients in "4 + 7" pilot cities

Wenxia Liu¹, Jun Ma², Zhao Yang³^,^*(), Bin Jiang¹^,^*()

1 Department of Administrative and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2 Peking University Third Hospital, Beijing 100191, China
3 Office of Academic Research of Peking University First Hospital, Beijing 100034, China

Received:2022-10-23 Revised:2022-12-26 Accepted:2023-01-08 Online:2023-04-29 Published:2023-04-29
Contact: Zhao Yang, Bin Jiang

摘要/Abstract

摘要：

中国仿制药替代受到多种因素的影响, 然而现有的研究主要集中在政策分析和临床使用上。本文旨在从"4 + 7"带量采购精神科用药患者角度, 研究中国仿制药替代的影响因素。以问卷调研四个试点城市精神科患者的人口特征、使用中选仿制药意愿及影响因素等, 并对其进行统计分析。研究发现, 单因素影响分析中, 使用中选仿制药意愿与患者教育水平、年龄、平均月收入、患病时间、患病程度显著相关; 影响因素回归分析中, 使用中选仿制药意愿与患者年龄显著相关。因此, 政府应当重视中青年群体在仿制药替代中的作用, 进行差异化管理, 加强对各方人士的教育宣传, 调整中选仿制药的医保支付标准, 要求医生对目标患者提出使用中选仿制药建议。

关键词: 仿制药替代, 影响因素, 带量采购, 精神科用药

Abstract:

In China, generic drug substitution is affected by multiple factors. However, existing studies mainly focus on policy analysis and clinical use. Therefore, we aimed to investigate the influencing factors in psychiatric patients in China’s "4 + 7" pilot cities. The demographic characteristics, willingness to use Chinese generic drugs, and influencing factors of psychiatric patients in four pilot cities were investigated by questionnaire, and the results were statistically analyzed. Univariate analysis revealed that the willingness to use the selected generic drugs was significantly correlated with educational background, age, average monthly income, time of illness, and severity of illness. Furthermore, logistic regression analysis indicated that the willingness to use the selected generic drugs was significantly associated with patients’ age. Therefore, the government should pay attention to the role of young and middle-aged groups in the substitution of generic drugs, carry out differential management, strengthen education and propaganda to all parties, adjust the standard of medical insurance payment for the selected generic drugs, and ask doctors to make suggestions on the use of selected generic drugs to target patients.

Key words: Generic drug substitution, Influencing factors, Volume-based procurement, Psychiatric patients

Supporting:

刘文夏, 马俊, 杨照, 江滨. 中国仿制药替代影响因素分析——基于"4 + 7"带量采购精神科用药患者角度[J]. 中国药学(英文版), 2023, 32(4): 317-321.

Wenxia Liu, Jun Ma, Zhao Yang, Bin Jiang. Influencing factors of generic drug substitution in China—from the perspective of psychiatric patients in "4 + 7" pilot cities[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(4): 317-321.

图/表 6

Table 1. Demographics of questionnaire respondents.

Figure 1. Influencing factors of willingness to switch to the bid-winning generic drugs.

Table 2. Single factor analysis and t-test results of demographic characteristics.

Table 3. Single factor analysis and t-test results of prevalence.

Table 4. Factors influencing the willingness of patients to use the selected generic drugs.

Table 5. Logistic regression analysis of factors influencing the willingness to use the selected generic drugs.

参考文献 9

[1]	NHC. Statistical Bulletin on the Development of Health Care in China in 2020. Chin. J. Pract. Rural Doctors. 2021, 28, 1–10.
[2]	Zhao, M.Y.; Zhang, L.Y.; Feng, Z.T.; Fang, Y. Physicians’ knowledge, attitude and practice of generic substitution in China: a cross-sectional online survey. Int. J. Environ. Res. Public Health. 2021, 18, 7749.
[3]	Ess, S.M.; Schneeweiss, S.; Szucs, T.D. European healthcare policies for controlling drug expenditure. PharmacoEconomics. 2003, 21, 89–103.
[4]	Larpparisuth, N.; Pinpaiboon, S.; Ratchawang, N.; Promraj, R.; Skulratanasak, P.; Vongwiwatana, A.; Premasathian, N. A study of the pharmacokinetic comparison between the generic and original form of mycophenolate mofetil among Thai renal transplant patients. Transplant. Proc. 2019, 51, 2629–2632.
[5]	Luo, N.T.; Yue, J.Y.; Zhou, R.J.; Jiang, B. The effects of the National Drug Pooled Procurement (NDPP) pilot program in China. J. Chin. Pharm. Sci. 2022, 31, 212–217.
[6]	Nie, Y.Y.; Wang, H.; Zhou, L.G.; Shi, L.W.; Jiang, B. Pharmacists’ perceptions of generic drugs in China. J. Chin. Pharm. Sci. 2020, 29, 364–368.
[7]	Howard, J.N.; Harris, I.; Frank, G.; Kiptanui, Z.; Qian, J.J.; Hansen, R. Influencers of generic drug utilization: a systematic review. Res. Social Adm. Pharm. 2018, 14, 619–627.
[8]	Nokelainen, H.; Lämsä, E.; Ahonen, R.; Timonen, J. Reasons for allowing and refusing generic substitution and factors determining the choice of an interchangeable prescription medicine: a survey among pharmacy customers in Finland. BMC Health Serv. Res. 2020, 20, 82.
[9]	Drozdowska, A.; Hermanowski, T. Exploring the opinions and experiences of patients with generic substitution: a representative study of Polish society. Int. J. Clin. Pharm. 2015, 37, 68–75.

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中国仿制药替代影响因素分析——基于"4 + 7"带量采购精神科用药患者角度

Influencing factors of generic drug substitution in China—from the perspective of psychiatric patients in "4 + 7" pilot cities

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