天然产物通过调节活性氧水平防治肿瘤的研究进展

doi:10.5246/jcps.2021.06.035

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (6): 455-467.DOI: 10.5246/jcps.2021.06.035

• 【综述】 • 下一篇

天然产物通过调节活性氧水平防治肿瘤的研究进展

汪子翔¹^,², 张宜凡¹, 杜望春¹, 陈群力¹, 姚虹¹, 赵梅¹^,^*()

1. 上海健康医学院药学院, 上海 201318
2. 上海中医药大学研究生院, 上海 201230

收稿日期:2020-11-18 修回日期:2020-12-26 接受日期:2021-03-10 出版日期:2021-06-29 发布日期:2021-06-29
通讯作者: 赵梅
作者简介:
+ Tel.: +86-21-65887579, E-mail: zhaomei100@163.com
基金资助:
National Natural Science Foundation of China (Grant No. 81602729).

Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level

Zixiang Wang¹^,², Yifan Zhang¹, Wangchun Du¹, Qunli Chen¹, Hong Yao¹, Mei Zhao¹^,^*()

1 Department of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China
2 Graduate?School, Shanghai University of Chinese Medicine, Shanghai 201230, China

Received:2020-11-18 Revised:2020-12-26 Accepted:2021-03-10 Online:2021-06-29 Published:2021-06-29
Contact: Mei Zhao

About author:

Zhao Mei received her Ph.D. from School of Pharmacy, Shanghai Jiao Tong University in 2010. She works at the Department of Pharmacy, Shanghai University of Medicine & Health Sciences, as an associate professor, and her research focuses on antitumor drugs and their drug delivery in oncology therapy. 赵梅, 2010年毕业于上海交通大学药学院, 获博士学位。现任上海健康医学院药学院副教授, 主要研究方向为抗肿瘤药物及其在肿瘤治疗中的药物递送。

摘要/Abstract

摘要：

活性氧(Reactive oxygen species, ROS)广泛存在于生物体内。正常情况下的ROS水平保持较低浓度以维持正常细胞功能。研究发现, 正常组织中ROS水平的异常升高将诱导的肿瘤发生发展; 而进一步提高浓度的ROS则具有诱导肿瘤细胞凋亡等抗肿瘤作用。ROS已成为肿瘤防治研究的重要靶点之一。天然产物广泛存在于自然界, 具有影响ROS水平等广泛的药理活性。本文综述了近年来天然产物通过调节ROS水平来预防和治疗肿瘤的研究进展。

关键词: 天然产物, 抗肿瘤, 活性氧, 水平

Abstract:

Reactive oxygen species (ROS) is widespread in living organisms. Under normal conditions, ROS remains at low concentrations to maintain normal cell function. Studies have found that the abnormal elevation of ROS levels in normal tissues is an important mechanism underlying the tumorigenesis. However, high concentrations of ROS also have toxic, genotoxic, and even apoptotic effects on tumor cells. ROS has become one of the important targets for cancer prevention and treatment. Natural products widely exist in nature and have a wide range of pharmacological activities, which can affect the function of ROS. In the present study, we reviewed the research progress of natural products in tumor prevention and treatment by regulating ROS level in recent years.

Key words: Natural products, Antitumor therapy, ROS, Level

Supporting:

汪子翔, 张宜凡, 杜望春, 陈群力, 姚虹, 赵梅. 天然产物通过调节活性氧水平防治肿瘤的研究进展[J]. 中国药学(英文版), 2021, 30(6): 455-467.

Zixiang Wang, Yifan Zhang, Wangchun Du, Qunli Chen, Hong Yao, Mei Zhao. Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 455-467.

图/表 5

Table 1. Natural products in antitumor therapy through increasing ROS.

Figure 1. Structures of compounds inducing the intrinsic (mitochondrial) apoptosis pathway.

Figure 2. Structures of compounds inducing the extrinsic apoptosis pathway.

Figure 3. Structures of compounds inducing autophagy.

Figure 4. Structures of compounds augmenting therapeutic efficacy of cisplatin and MMC.

参考文献 67

[1]	Xu, Q.H.; He, C.L.; Xiao, C.S.; Chen, X.S. Reactive oxygen species (ROS) responsive polymers for biomedical applications. Macromol. Biosci. 2016, 16, 635–646.
[2]	Glasauer, A.; Chandel, N.S. Targeting antioxidants for cancer therapy. Biochem. Pharmacol. 2014, 92, 90–101.
[3]	Zhang, J.X.; Wang, X.L.; Vikash, V.; Ye, Q.; Wu, D.D.; Liu, Y.L.; Dong, W.G. ROS and ROS-mediated cellular signaling. Oxidat. Med. Cell Longev. 2016, 2016, 1–18.
[4]	de Sá Junior, P.L.; Câmara, D.A.D.; Porcacchia, A.S.; Fonseca, P.M.M.; Jorge, S.D.; Araldi, R.P.; Ferreira, A.K. The roles of ROS in cancer heterogeneity and therapy. Oxidat. Med. Cell Longev. 2017, 2017, 2467940.
[5]	Safe, S.; Kasiappan, R. Natural products as mechanism-based anticancer agents: sp transcription factors as targets. Phytother. Res. 2016, 30, 1723–1732.
[6]	Galadari, S.; Rahman, A.; Pallichankandy, S.; Thayyullathil, F. Reactive oxygen species and cancer paradox: To promote or to suppress? Free Radic. Biol. Med. 2017, 104, 144–164.
[7]	Tong, L.Y.; Chuang, C.C.; Wu, S.Y.; Zuo, L. Reactive oxygen species in redox cancer therapy. Cancer Lett. 2015, 367, 18–25.
[8]	Son, J.; Lyssiotis, C.A.; Ying, H.Q.; Wang, X.X.; Hua, S.J.; Ligorio, M.; Perera, R.M.; Ferrone, C.R.; Mullarky, E.; Shyh-Chang, N.; Kang, Y.A.; Fleming, J.B.; Bardeesy, N.; Asara, J.M.; Haigis, M.C.; DePinho, R.A.; Cantley, L.C.; Kimmelman, A.C. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013, 496, 101–105.
[9]	Patra, K.C.; Hay, N. The pentose phosphate pathway and cancer. Trends Biochem. Sci. 2014, 39, 347–354.
[10]	Yun, J.; Mullarky, E.; Lu, C.; Bosch, K.N.; Kavalier, A.; Rivera, K.; Roper, J.; Chio, I.I.C.; Giannopoulou, E.G.; Rago, C.; Muley, A.; Asara, J.M.; Paik, J.; Elemento, O.; Chen, Z.; Pappin, D.J.; Dow, L.E.; Papadopoulos, N.; Gross, S.S.; Cantley, L.C. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015, 350, 1391–1396.
[11]	Nathan, C.; Cunningham-Bussel, A. Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat. Rev. Immunol. 2013, 13, 349–361.
[12]	Yang, Y.; Karakhanova, S.; Werner, J.; Bazhin, A. Reactive oxygen species in cancer biology and anticancer therapy. Curr. Med. Chem. 2013, 20, 3677–3692.
[13]	Klaunig, J.E.; Wang, Z.M.; Pu, X.Z.; Zhou, S.Y. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol. Appl. Pharmacol. 2011, 254, 86–99.
[14]	Bazhin, A.V.; Philippov, P.P.; Karakhanova, S. Reactive oxygen species in cancer biology and anticancer therapy. Oxidat. Med. Cell Longev. 2016, 2016, 1–2.
[15]	Ziech, D.; Franco, R.; Pappa, A.; Panayiotidis, M.I. Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis. Mutat. Res. 2011, 711, 167–173.
[16]	Campbell, K.J.; Tait, S.W.G. Targeting BCL-2 regulated apoptosis in cancer. Open Biol. 2018, 8, 180002.
[17]	Lee, H.H.; Park, C.; Jeong, J.W.; Kim, M.J.; Seo, M.J.; Kang, B.W.; Park, J.U.; Kim, G.Y.; Choi, B.T.; Choi, Y.H.; Jeong, Y.K. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species-mediated mitochondrial death pathway. Int. J. Oncol. 2013, 42, 1036–1044.
[18]	Ozben, T. Oxidative stress and apoptosis: Impact on cancer therapy. J. Pharm. Sci. 2007, 96, 2181–2196.
[19]	Nottingham, E.; Sekar, V.; Mondal, A.; Safe, S.; Rishi, A.K.; Singh, M. The role of self-nanoemulsifying drug delivery systems of CDODA-me in sensitizing erlotinib-resistant non-small cell lung cancer. J. Pharm. Sci. 2020, 109, 1867–1882.
[20]	Yang, C.; Peng, S.; Sun, Y.M.; Miao, H.T.; Lyu, M.; Ma, S.J.; Luo, Y.; Xiong, R.; Xie, C.H.; Quan, H. Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement. Royal Soc. Open Sci. 2019, 6, 181790.
[21]	D’Arcy, M.S. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol. Int. 2019, 43, 582–592.
[22]	Redza-Dutordoir, M.; Averill-Bates, D.A. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim. et Biophys. Acta BBA-Mol. Cell Res. 2016, 1863, 2977–2992.
[23]	Bhutia, S.K.; Behera, B.; Nandini Das, D.; Mukhopadhyay, S.; Sinha, N.; Panda, P.K.; Naik, P.P.; Patra, S.K.; Mandal, M.; Sarkar, S.; Menezes, M.E.; Talukdar, S.; Maiti, T.K.; Das, S.K.; Sarkar, D.; Fisher, P.B. Abrus agglutinin is a potent anti-proliferative and anti-angiogenic agent in human breast cancer. Int. J. Cancer. 2016, 139, 457–466.
[24]	Chen, Y.; Azad, M.B.; Gibson, S.B. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 2009, 16, 1040–1052.
[25]	Zhao, D.X.; Wang, C.C.; Tang, S.S.; Zhang, C.M.; Zhang, S.; Zhou, Y.; Xiao, X.L. Reactive oxygen species-dependent JNK downregulated olaquindox-induced autophagy in HepG2 cells. J. Appl. Toxicol. 2015, 35, 709–716.
[26]	Villar, V.H.; Merhi, F.; Djavaheri-Mergny, M.; Durán, R.V. Glutaminolysis and autophagy in cancer. Autophagy. 2015, 11, 1198–1208.
[27]	Thorburn, A.; Thamm, D.H.; Gustafson, D.L. Autophagy and cancer therapy. Mol. Pharmacol. 2014, 85, 830–838.
[28]	Li, L.L.; Tan, J.; Miao, Y.Y.; Lei, P.; Zhang, Q. ROS and autophagy: interactions and molecular regulatory mechanisms. Cell Mol. Neurobiol. 2015, 35, 615–621.
[29]	Nogueira, V.; Hay, N. Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin. Cancer Res. 2013, 19, 4309–4314.
[30]	Guo, F.; Yang, F.; Zhu, Y.H. Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. Nat. Prod. Res. 2019, 33, 2372–2375.
[31]	Ye, F.F.; Wang, H.H.; Zhang, L.S.; Zou, Y.Y.; Han, H.L.; Huang, J. Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP₃ expression. Tumour Biol. 2015, 36, 4731–4740.
[32]	Chang, Z.Q.; Xing, J.C.; Yu, X.C. Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway. Tumour Biol. 2014, 35, 753–758.
[33]	Wu, D.D.; Zhang, J.X.; Wang, J.; Li, J.; Liao, F.; Dong, W.G. Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species. Tumour Biol. 2016, 37, 3451–3459.
[34]	Wang, C.Y.; Lin, C.S.; Hua, C.H.; Jou, Y.J.; Liao, C.R.; Chang, Y.S.; Wan, L.; Huang, S.H.; Hour, M.J.; Lin, C.W. Cis-3-O-p-hydroxycinnamoyl ursolic acid induced ROS-dependent p53-mediated mitochondrial apoptosis in oral cancer cells. Biomol. Ther. 2019, 27, 54–62.
[35]	Peng, K.T.; Chiang, Y.C.; Ko, H.H.; Chi, P.L.; Tsai, C.L.; Ko, M.I.; Lee, M.H.; Hsu, L.F.; Lee, C.W. Mechanism of lakoochin A inducing apoptosis of A375.S2 melanoma cells through mitochondrial ROS and MAPKs pathway. Int. J. Mol. Sci. 2018, 19, 2649.
[36]	Wang, S.H.; Hu, Y.L.; Yan, Y.; Cheng, Z.K.; Liu, T.X. Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway. BMC Complement. Altern. Med. 2018, 18, 235.
[37]	Tan, B.L.; Norhaizan, M.E.; Chan, L.C. ROS-mediated mitochondrial pathway is required for manilkara zapota (L.) P. royen leaf methanol extract inducing apoptosis in the modulation of caspase activation and EGFR/NF-κB activities of HeLa human cervical cancer cells. Evid. Based Complement. Alternat. Med. 2018, 2018, 1–19.
[38]	Yang, S.P.; Zhang, Y.G.; Luo, Y.; Xu, B.C.; Yao, Y.Q.; Deng, Y.L.; Yang, F.F.; Ye, T.H.; Wang, G.; Cheng, Z.Q.; Zheng, Y.; Xie, Y.M. Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomed. Pharmacother. 2018, 103, 101–110.
[39]	Aghvami, M.; Ebrahimi, F.; Zarei, M.H.; Salimi, A.; Pourahmad Jaktaji, R.; Pourahmad, J. Matrine induction of ROS mediated apoptosis in human ALL B-lymphocytes via mitochondrial targeting. Asian Pac. J. Cancer Prev. 2018, 19, 555–560.
[40]	Oh, J.M.; Kim, E.; Chun, S. Ginsenoside compound K induces ros-mediated apoptosis and autophagic inhibition in human neuroblastoma cells in vitro and in vivo. Int. J. Mol. Sci. 2019, 20, 4279.
[41]	Yang, H.L.; Lin, R.W.; Rajendran, P.; Mathew, D.C.; Thigarajan, V.; Lee, C.C.; Hsu, C.J.; Hseu, Y.C. Antrodia salmonea-induced oxidative stress abrogates HER-2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells. J. Cell Physiol. 2019, 234, 3029–3042.
[42]	Lu, Z.Y.; Zhang, G.X.; Zhang, Y.F.; Hua, P.Y.; Fang, M.D.; Wu, M.L.; Liu, T.J. Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells. Toxicol. Appl. Pharmacol. 2018, 352, 46–58.
[43]	Oh, H.; Yoon, G.; Shin, J.C.; Park, S.M.; Cho, S.S.; Cho, J.H.; Lee, M.H.; Liu, K.D.; Cho, Y.S.; Chae, J.I.; Shim, J.H. Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways. Int. J. Oncol. 2016, 48, 1749–1757.
[44]	Kwak, A.W.; Choi, J.S.; Lee, M.H.; Oh, H.N.; Cho, S.S.; Yoon, G.; Liu, K.D.; Chae, J.I.; Shim, J.H. Retrochalcone echinatin triggers apoptosis of esophageal squamous cell carcinoma via ROS- and ER stress-mediated signaling pathways. Molecules. 2019, 24, 4055.
[45]	Liu, Z.R.; Sun, L.Z.; Jia, T.H.; Jia, D.F. beta-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss. J. BUON. 2017, 22, 1582–1586.
[46]	Thiyagarajan, V.; Sivalingam, K.S.; Viswanadha, V.P.; Weng, C.F. 16-hydroxy-cleroda-3, 13-Dien-16, 15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2. Environ. Toxicol. Pharmacol. 2016, 45, 202–211.
[47]	Wang, H.; Zhang, T.; Sun, W.; Wang, Z.; Zuo, D.; Zhou, Z.; Li, S.; Xu, J.; Yin, F.; Hua, Y.; Cai, Z. Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo. Cell Death Dis. 2016, 7, e2247.
[48]	Zhou, S.F.; Pan, S.T.; Qin, Y.R.; Zhou, Z.W.; He, Z.X.; Zhang, X.J.; Yang, T.X.; Yang, Y.X.; Wang, D.; Qiu, J.X. Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI₃K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Des. Dev. Ther. 2015, 1601–1626.
[49]	Ma, K.; Zhang, C.; Huang, M.Y.; Li, W.Y.; Hu, G.Q. Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U₂OS cells through the ROS/JNK/p38 signaling pathway. Oncol. Rep. 2016, 36, 90–98.
[50]	Guo, Z.G.; Hu, G.Z.; Wang, H.; Li, Z.H.; Liu, N.J. Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway. Biomed. Pharmacother. 2019, 116, 108524.
[51]	Nicco, C.; Batteux, F. ROS modulator molecules with therapeutic potential in cancers treatments. Molecules. 2017, 23, 84.
[52]	Dasari, S.; Bernard Tchounwou, P. Cisplatin in cancer therapy: Molecular mechanisms of action. Eur. J. Pharmacol. 2014, 740, 364–378.
[53]	Chuang, C.Y.; Liu, H.C.; Wu, L.C.; Chen, C.Y.; Chang, J.T.; Hsu, S.L. Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J. Agric. Food Chem. 2010, 58, 2943–2951.
[54]	Russell, L.H.; Mazzio, E.; Badisa, R.B.; Zhu, Z.P.; Agharahimi, M.; Oriaku, E.T.; Goodman, C.B. Autoxidation of Gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells. Anticancer. Res. 2012, 32, 1595–1602.
[55]	Wang, R.X.; Ma, L.J.; Weng, D.; Yao, J.H.; Liu, X.Y.; Jin, F.G. Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway. Oncol. Rep. 2016, 35, 3075–3083.
[56]	Yan, C.Q.; Kong, D.C.; Ge, D.; Zhang, Y.M.; Zhang, X.S.; Su, C.H.; Cao, X.J. Mitomycin C induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via a mitochondrial-mediated pathway. Cell Physiol. Biochem. 2015, 35, 1125–1136.
[57]	Poornima, P.; Quency, R.S.; Padma, V.V. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food Chem. 2013, 136, 659–667.
[58]	Eid, W.; Abdel-Rehim, W. Neferine enhances the antitumor effect of mitomycin-C in hela cells through the activation of p38-MAPK pathway. J. Cell Biochem. 2017, 118, 3472–3479.
[59]	Prasad, S.; Gupta, S.C.; Tyagi, A.K. Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Lett. 2017, 387, 95–105.
[60]	Fischer, N.; Seo, E.J.; Efferth, T. Prevention from radiation damage by natural products. Phytomedicine. 2018, 47, 192–200.
[61]	Ichihashi, M.; Ahmed, N.U.; Budiyanto, A.; Wu, A.; Bito, T.; Ueda, M.; Osawa, T. Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J. Dermatol. Sci. 2000, 23, S45–S50.
[62]	Kallassy, H.; Fayyad-Kazan, M.; Makki, R.; El-Makhour, Y.; Hamade, E.; Rammal, H.; Leger, D.Y.; Sol, V.; Fayyad-Kazan, H.; Liagre, B.; Badran, B. Chemical composition, antioxidant, anti-inflammatory, and antiproliferative activities of the plant Lebanese crataegus azarolus L. Med. Sci. Monit. Basic Res. 2017, 23, 270–284.
[63]	El Abed, H.; Chakroun, M.; Abdelkafi-Koubaa, Z.; Drira, N.; Marrakchi, N.; Mejdoub, H.; Khemakhem, B. Antioxidant, anti-inflammatory, and antitumoral effects of aqueous ethanolic extract from Phoenix dactylifera L. parthenocarpic dates. Biomed Res. Int. 2018, 2018, 1542602.
[64]	Al-Awaida, W.; Al-Hourani, B.; Akash, M.; Talib, W.; Zein, S.; Falah, R. In vitro anticancer, anti-inflammatory, and antioxidant potentials of Ephedra aphylla. J. Cancer Res. Ther. 2018, 14, 1350–1354.
[65]	Mun, G.I.; Kim, S.; Choi, E.; Kim, C.S.; Lee, Y.S. Pharmacology of natural radioprotectors. Arch. Pharm. Res. 2018, 41, 1033–1050.
[66]	Zhu, W.Z.; Ma, L.; Yang, B.W.; Zheng, Z.D.; Chai, R.F.; Liu, T.T.; Liu, Z.J.; Song, T.Y.; Li, F.L.; Li, G.R. Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. Vitro Cell Dev. Biol. Animal. 2016, 52, 589–597.
[67]	Qiu, J.X.; Zhang, T.; Zhu, X.Y.; Yang, C.; Wang, Y.X.; Zhou, N.; Ju, B.X.; Zhou, T.H.; Deng, G.Z.; Qiu, C.W. Hyperoside induces breast cancer cells apoptosis via ROS-mediated NF-κB signaling pathway. Int. J. Mol. Sci. 2019, 21, 131.

天然产物通过调节活性氧水平防治肿瘤的研究进展

Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 5

参考文献 67

相关文章 15

编辑推荐

Metrics

本文评价

[1]	刘良裕, 杨宇珂, 杜肖, 吴桐, 王建农. 白英中三个未被报道的甾体糖苷生物碱及其抗肿瘤活性[J]. 中国药学(英文版), 2022, 31(3): 192-201.
[2]	许士琪, 朱礼岩, 郝超, 刘文倩, 陈成龙, 陈泳怡, 刘爱芹. 一种新型含氨基酸基团替加氟前药的合成及其抗肿瘤活性评价[J]. 中国药学(英文版), 2021, 30(9): 743-753.
[3]	黄聪, 吴霭琳, 海沙尔江·吾守尔, 徐子悦, 张逸晨, 管晓东, 史录文. 中国浙江省级医保报销对于靶向抗肿瘤药使用的影响: 一项带对照的间断时间序列分析[J]. 中国药学(英文版), 2021, 30(7): 590-597.
[4]	宋慧慧, 向卓, 薛淑一, 苗青, 赵丽艳, 李明春. 白头翁皂苷及其单体抗肿瘤作用及机制的研究进展[J]. 中国药学(英文版), 2021, 30(5): 381-392.
[5]	李诗慧, 郭可蒙, 尹妮颖, 单明珠, 祝垚, 李颖. 茶皂素诱导活性氧产生介导白色念珠菌线粒体功能障碍[J]. 中国药学(英文版), 2021, 30(11): 895-903.
[6]	王景茹, 张爽, 李卓越, 徐美琦, 王光雪, 张烜. 用于光动力疗法的pH敏感性碳酸钙-二氢卟吩e6纳米粒的制备与表征[J]. 中国药学(英文版), 2021, 30(11): 904-911.
[7]	刘曼, 张爽, 李卓越, 王光雪, 王景茹, 张烜. 氧化锌纳米粒的制备与表征[J]. 中国药学(英文版), 2020, 29(9): 617-625.
[8]	周北斗, 俞紫涵, 童玉贵, 李佳莉, 黄堡城, 魏蓉蓉, 翁智敏, 王欣, 阮志鹏, 林健, 许彩红, 刘建波. 异戊烯基和香叶基取代的呫吨酮的合成与生物活性研究[J]. 中国药学(英文版), 2020, 29(8): 564-576.
[9]	靳玉瑞, 李爱秀, 康家雄. 基于2009 H1N1神经氨酸酶天然产物抑制剂的作用模式的研究[J]. 中国药学(英文版), 2020, 29(6): 390-397.
[10]	耿彤彤, 王贵阳, 马学洋, 张中义, 刘谈, 葛元洁, 金晶, 孙晓旭, 张英涛, 杨东辉, 马明. Bacillus sp. PKU-TA00001中发现的色胺类天然产物[J]. 中国药学(英文版), 2019, 28(8): 527-536.
[11]	程文文, 张冬梅, 郑强, 李中军, 孟祥豹. 新型组蛋白去乙酰化酶抑制剂的设计、合成及活性评价: 含硫锌离子结合基团的发现 [J]. 中国药学(英文版), 2019, 28(6): 408-421.
[12]	周北斗, 王欣, 翁智敏, 黄堡城, 马泽通, 于博, 阮丽琴, 胡栋宝. 氧杂蒽酮的合成和抗肿瘤、抑制酪氨酸酶和抑制血小板聚集活性研究[J]. 中国药学(英文版), 2019, 28(4): 247-256.
[13]	北京大学药学院. 贾彦兴教授团队在复杂天然产物全合成领域连续取得突破性进展[J]. 中国药学(英文版), 2019, 28(4): 284-286.
[14]	郝艳丽, 钟婷, 杜若, 张华, 刘碧林, 张烜. 包载共轭亚油酸-紫杉醇的iRGD修饰的含溶血磷脂的温敏脂质体的细胞摄取和抗肿瘤药效[J]. 中国药学(英文版), 2019, 28(2): 121-133.
[15]	卢东渤, 陈宇, 刘姗, 郭超, 李霞, 李中军, 孟祥豹. 茚[1, 2-b]并吲哚衍生物的合成、双重抑制拓扑异构酶I和II及逆转多重耐药等生物活性研究[J]. 中国药学(英文版), 2019, 28(11): 786-801.