氧化锌纳米粒的制备与表征

doi:10.5246/jcps.2020.09.057

中国药学(英文版) ›› 2020, Vol. 29 ›› Issue (9): 617-625.DOI: 10.5246/jcps.2020.09.057

氧化锌纳米粒的制备与表征

刘曼^1,2, 张爽^1,2, 李卓越^1,2, 王光雪², 王景茹^1,2, 张烜^1,2*

1. 北京大学医学部药学院分子药剂学与新释药系统北京市重点实验室, 北京 100191
2. 北京大学医学部药学院药剂学系, 北京 100191

收稿日期:2020-05-27 修回日期:2020-06-07 出版日期:2020-09-30 发布日期:2020-08-15
通讯作者: Tel./Fax: +86-10-82805765, E-mail: xuanzhang@bjmu.edu.cn
基金资助:
National Natural Science Foundation of China (Grant No. 81773646), the National Key Research and Development Program of China (Grant No. 2017YFA0205600), and the Innovation Team of the Ministry of Education (Grant No. BMU2017TD003).

Preparation and characterization of zinc oxide nanoparticles

Man Liu^1,2, Shuang Zhang^1,2, Zhuoyue Li^1,2, Guangxue Wang², Jingru Wang^1,2, Xuan Zhang^1,2*

1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2020-05-27 Revised:2020-06-07 Online:2020-09-30 Published:2020-08-15
Contact: Tel./Fax: +86-10-82805765, E-mail: xuanzhang@bjmu.edu.cn
Supported by:
National Natural Science Foundation of China (Grant No. 81773646), the National Key Research and Development Program of China (Grant No. 2017YFA0205600), and the Innovation Team of the Ministry of Education (Grant No. BMU2017TD003).

摘要/Abstract

摘要：

本研究采用溶胶-凝胶法制备氧化锌纳米粒(ZnO NPs),并对其粒径、形貌、晶型、光学特性和pH敏感性等理化性质进行表征,在PC-3M和4T1两株细胞系上对ZnO NPs的体外抗肿瘤药效进行评价。实验结果表明, ZnO NPs为粒径均匀的球形纳米颗粒,具有优良的光学性能及pH敏感性能,对PC-3M和4T1两株细胞系有明显的抗肿瘤细胞药效。上述结果表明, ZnO NPs可作为载体载带活性物质以产生抗肿瘤诊断和治疗作用。

关键词: 氧化锌纳米粒, 溶胶-凝胶法, 粒径与形貌, 光学性质, 抗肿瘤药效

Abstract:

In the present study, the zinc oxide nanoparticles (ZnO NPs) were prepared by using a sol-gel method. The characterizationof ZnO NPs, such as particle size, morphology, crystal form, optical properties and pH-responsive behavior, was carried out. The in vitro anti-tumor activity of ZnO NPs was evaluated on PC-3M and 4T1 cell lines. The results indicated that ZnO NPs were spherical NPs with uniform particle size, excellent fluorescence properties, and pH-responsive behavior. The in vitro anti-tumor activity of ZnO NPs was observed on PC-3M and 4T1 cell lines. Considering to above characteristics, ZnO NPs could be used as drug delivery carries for loading active compound performing therapeutic and diagnostic effect.

Key words: Zinc oxide nanoparticles, Sol-gel method, Size and morphology, Optical properties, In vitro anti-tumor activity

中图分类号:

R944

Supporting:

刘曼, 张爽, 李卓越, 王光雪, 王景茹, 张烜. 氧化锌纳米粒的制备与表征[J]. 中国药学(英文版), 2020, 29(9): 617-625.

Man Liu, Shuang Zhang, Zhuoyue Li, Guangxue Wang, Jingru Wang, Xuan Zhang. Preparation and characterization of zinc oxide nanoparticles[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(9): 617-625.

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氧化锌纳米粒的制备与表征

Preparation and characterization of zinc oxide nanoparticles

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