二聚乳糖化合物的合成及其抗休克活性研究

二聚乳糖化合物的合成及其抗休克活性研究

张婉, 李庆, 孟祥豹, 赵致辉, 李中军^*

1. 北京大学药学院化学生物学系, 北京100083;
2. 南京师范大学生命科学院, 南京 210097

收稿日期:2007-01-09 修回日期:2007-05-10 出版日期:2007-06-15 发布日期:2007-06-15
通讯作者: 李中军*

Synthesis and anti-shock activity of divalent β-D-galactopyranosyl-(1→4)-β-D-glucopyranosides

Wan Zhang, Qing Li, Xiang-Bao Meng, Zhi-Hui Zhao, Zhong-Jun Li^*

1. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;
2. Life Science College, Nanjing Normal University, Nanjing 2100097, China

Received:2007-01-09 Revised:2007-05-10 Online:2007-06-15 Published:2007-06-15
Contact: Zhong-Jun Li*

摘要/Abstract

摘要： 目的以七乙酰-1-α-溴代乳糖为供体,以不同聚合度的缩乙二醇(n = 4, 5, 6)为连接臂合成三个二聚乳糖化合物；以重症烧伤大鼠为模型，研究其体内抗白细胞-内皮细胞粘附活性。结果研究表明与对照组(食盐水)相比，这三个合成的二聚乳糖化合物具有良好的抗休克活性。结论以缩乙二醇为连接臂合成的二聚乳糖化合物具有良好的抗休克活性；聚合度的不同，对抗休克活性有显著影响。

关键词: 二聚乳糖化合物, 二聚乳糖化合物, 二聚乳糖化合物, 抗休克, 抗休克, 抗休克, 白细胞-内皮细胞粘附, 白细胞-内皮细胞粘附, 白细胞-内皮细胞粘附

Abstract: Three divalent β-D-galactopyranosyl-(1→ 4)-β-D-glucopyranosides were synthesized using acetylated lactosyl bromide as donor and polyethylene glycols with different polymeric degree (n = 4, 5, 6) as linker, and evaluated for in vivo inhibitory activity to leukocyte-endothelial cell adhesion on severe burn-shock rats. The result showed that the length of linkers had apparent influence on anti cell adhesion activity.

Key words: Divalent lactosides, Divalent lactosides, Leukocyte-endothelial cell, Leukocyte-endothelial cell, Anti-shock, Anti-shock

中图分类号:

R916

Supporting: Foundation item: National Natural Science Foundation of China (No. 20372003)
^*Corresponding author. Tel.: 86-10-82801714; fax: 86-10-62367134

张婉, 李庆, 孟祥豹, 赵致辉, 李中军^*. 二聚乳糖化合物的合成及其抗休克活性研究[J]. .

Wan Zhang, Qing Li, Xiang-Bao Meng, Zhi-Hui Zhao, Zhong-Jun Li^*. Synthesis and anti-shock activity of divalent β-D-galactopyranosyl-(1→4)-β-D-glucopyranosides[J]. .

参考文献

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