以氨基酸甲酯和异硫氰酸酯为原料碱性Al2O3为载体合成硫代乙内酰脲的有效方法

doi:10.5246/jcps.2012.02.017

以氨基酸甲酯和异硫氰酸酯为原料碱性Al₂O₃为载体合成硫代乙内酰脲的有效方法

李刚, 刘玉鹏, 雷蒙, 王欣^*, 程铁明, 李润涛^*

北京大学医学部天然药物及仿生药物国家重点实验室; 药学院化学生物学系, 北京 100191

收稿日期:2011-11-11 修回日期:2011-01-15 出版日期:2012-03-15 发布日期:2012-03-15
通讯作者: 王欣*, 李润涛*

Efficient synthesis of thiohydantoin derivatives from amino acid esters and isothiocyanates in alkaline Al₂O₃

Gang Li, Yu-Peng Liu, Meng Lei, Xin Wang^*, Tie-Ming Cheng, Run-Tao Li^*

State Key Laboratory of Natural and Biomimetic Drugs; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China

Received:2011-11-11 Revised:2011-01-15 Online:2012-03-15 Published:2012-03-15
Contact: Xin Wang*, Run-Tao Li*

摘要/Abstract

摘要：

室温下以碱性氧化铝为载体, 多种氨基酸甲酯与不同的异硫氰酸酯反应1小时可以很高收率得到相应的异硫氰酸酯。

关键词: 硫代乙内酰脲, 氨基酸甲酯, 异硫氰酸酯, 碱性氧化铝, 有机合成

Abstract: Various amino acid esters were reacted with different isothiocyanates in alkaline Al₂O₃ at room temperature for 1 h affording thiohydantoins in moderate to excellent yields.

Key words: Thiohydantoin, Amino acid ester, Isothiocyanate, Alkaline Al2O3, Synthesis

中图分类号:

R916

Supporting: Foundation item: National Natural Science Foundation of China (Grant No. 20972005).
^*Corresponding author. Tel.: 86-10-82801504; Fax: 86-10-82716956

李刚, 刘玉鹏, 雷蒙, 王欣^*, 程铁明, 李润涛^*. 以氨基酸甲酯和异硫氰酸酯为原料碱性Al₂O₃为载体合成硫代乙内酰脲的有效方法[J]. , DOI: 10.5246/jcps.2012.02.017.

Gang Li, Yu-Peng Liu, Meng Lei, Xin Wang^*, Tie-Ming Cheng, Run-Tao Li^*. Efficient synthesis of thiohydantoin derivatives from amino acid esters and isothiocyanates in alkaline Al₂O₃[J]. , DOI: 10.5246/jcps.2012.02.017.

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以氨基酸甲酯和异硫氰酸酯为原料碱性Al₂O₃为载体合成硫代乙内酰脲的有效方法

Efficient synthesis of thiohydantoin derivatives from amino acid esters and isothiocyanates in alkaline Al₂O₃

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