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赤芝子实体中三萜化学成分的研究

王芳生, 蔡辉, 杨峻山*, 张聿梅, 赵英举   

  1. 1. 中国人民解放军农牧大学, 长春 130062;
    2. 中国医学科学院 中国协和医科 大学药用植物研究所, 北京 100094
  • 收稿日期:1996-08-23 修回日期:1997-04-08 出版日期:1997-12-15 发布日期:1997-12-15
  • 通讯作者: 杨峻山*

Triterpenoids from the Fruiting Body of Ganoderma lucidum

Fang-Sheng Wang, Hui Cai, Jun-Shan Yang*, Yu-Mei Zhang, Ying-Ju Zhao   

  1. 1. Department of Chemistry, University of Agriculture and Animal Science, PLA, Changchun 130062; 
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094
  • Received:1996-08-23 Revised:1997-04-08 Online:1997-12-15 Published:1997-12-15
  • Contact: Jun-Shan Yang*

摘要: 自赤芝[Ganoderma lucidum (Fr.) Karst]的二氯甲烷溶解部分分离得到一个新的三萜内酯化合物,命名为灵芝内酯(ganolactone)。根据光谱(UV, IR, 1H NMR, 13C NMR, MS 2D NMR)解析, 确定其结构为1式。同时还从赤芝子实体中分到三个已知化合物,即灵芝醇A(ganoderiol A, 2), 灵芝醇B(ganoderiolB, 3)和灵芝三醇(ganodermatriol 4)

关键词: 赤芝, 灵芝内酯, 三萜

Abstract: A new triterpenoid, named ganolactone, was isolated from the CH2Cl2 soluble fraction of the fruiting body of Ganoderma lucidum. Its structure was deduced as 7β-hydroxy-3,11,15-trioxo-lanosta-8-en-24→20s lactone (1) on the basis of spectral analysis (UV, IR, MS, 1H NMR, 13C NMR and 2D NMR) and was confirmed by X-ray diffraction. In addition, three known compounds, ganoderiol A (2), ganoderiol B (3) and ganodermatriol (4), were obtained.

Key words: Ganoderma lucidum, Triterpenoid, Ganolactone

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