单股正链RNA (+ssRNA)病毒非编码区研究进展

doi:10.5246/jcps.2025.01.001

中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (1): 1-13.DOI: 10.5246/jcps.2025.01.001

• 【综述】 • 下一篇

单股正链RNA (+ssRNA)病毒非编码区研究进展

郭亮荣¹^,²^,³^,⁴, 刘国月¹^,²^,³^,⁴, 孙巨¹^,²^,³^,⁴, 位灯国¹^,²^,³^,⁴^,^*()

^1. 华中农业大学农业微生物资源发掘与利用全国重点实验室, 湖北武汉 430070
^2. 华中农业大学交叉科学研究院湖北洪山实验室, 湖北武汉 430070
^3. 华中农业大学国家兽药残留基准实验室, 国家兽药安全评价实验室, 湖北武汉 430070
^4. 中国农业科学院深圳农业基因组研究所, 广东深圳 518000

收稿日期:2024-10-27 修回日期:2024-11-05 接受日期:2024-12-23 出版日期:2025-02-20 发布日期:2025-02-20
通讯作者: 位灯国

Research progress on the non-coding region of single-stranded positive-sense RNA (+ssRNA) viruses

Liangrong Guo¹^,²^,³^,⁴, Guoyue Liu¹^,²^,³^,⁴, Ju Sun¹^,²^,³^,⁴, Dengguo Wei¹^,²^,³^,⁴^,^*()

¹ National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China
² Hubei Hongshan Laboratory, Interdisciplinary Sciences Institute, Huazhong Agricultural University, Wuhan 430070, Hubei, China
³ National Reference Laboratory of Veterinary Drug Residues (HZAU) and National Laboratory of Safety Evaluation for Veterinary Drug (HZAU), Huazhong Agricultural University, Wuhan 430070, Hubei, China
⁴ Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture), Shenzhen 518000, Guangdong, China

Received:2024-10-27 Revised:2024-11-05 Accepted:2024-12-23 Online:2025-02-20 Published:2025-02-20
Contact: Dengguo Wei
Supported by:
National Key Research and Development Programs of China (Grant No. 2021YFD1801102), the National Natural Science Foundation of China (Grant No. 22077043, 32473010), the Fundamental Research Funds for the Central Universities (2662023PY005 to DW), HZAU-AGIS Cooperation Fund (SZYJY2022016 to DW), Natural Science Foundation of Hubei Province (2021CFA061 to DW), and the Funding from National Key Laboratory of Agricultural Microbiology (AML2023B05 to DW).

摘要/Abstract

摘要：

单股正链RNA病毒种类繁多, 对人类和动物健康以及农业经济生产具有重大影响。病毒的5′和3′非翻译区(UTRs)在翻译起始与调控、RNA合成、病毒组装及毒力等方面发挥着关键作用。本文介绍了一些具有代表性的正义单链RNA病毒种类的非翻译区, 并探讨了它们在疫苗研究中的前景以及一些现存问题。

关键词: 正链单链RNA病毒, 非翻译区(UTR), 结构, 疫苗

Abstract:

Single-stranded positive-sense RNA (+ssRNA) viruses encompass a diverse range of species and exert profound effects on human and animal health, as well as agricultural economic productivity. The 5ʹ and 3ʹ untranslated regions (UTRs) of these viruses play pivotal roles in regulating critical processes such as translation initiation, RNA synthesis, virus assembly, and virulence. This article provided an overview of the untranslated regions in representative species of single-stranded positive-sense RNA (+ssRNA) viruses, highlighting their potential in vaccine development research and addressing some of the challenges currently faced in this field.

Key words: +ssRNA virus, UTR, Structure, Vaccine

Supporting:

郭亮荣, 刘国月, 孙巨, 位灯国. 单股正链RNA (+ssRNA)病毒非编码区研究进展[J]. 中国药学(英文版), 2025, 34(1): 1-13.

Liangrong Guo, Guoyue Liu, Ju Sun, Dengguo Wei. Research progress on the non-coding region of single-stranded positive-sense RNA (+ssRNA) viruses[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(1): 1-13.

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单股正链RNA (+ssRNA)病毒非编码区研究进展

Research progress on the non-coding region of single-stranded positive-sense RNA (+ssRNA) viruses

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