固体制剂物理结构的研究进展

doi:10.5246/jcps.2024.10.064

中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (10): 877-905.DOI: 10.5246/jcps.2024.10.064

• 【综述】 •

固体制剂物理结构的研究进展

李哲¹^,^#, 罗晓岁¹^,^#, Abid Naeem¹, 李琼¹, 张尧², 管咏梅¹, 陈丽华¹, 朱卫丰¹, 金正吉¹, 冯怡¹^,³, 明良山¹^,^*()

^1. 江西中医药大学高等研究院现代中药制剂教育部重点实验室, 江西南昌 330004
^2. 中药固体制剂国家制药工程技术研究中心, 江西南昌 330004
^3. 上海中医药大学中药现代制备技术教育部工程研究中心, 上海 201203

收稿日期:2024-01-08 修回日期:2024-02-12 接受日期:2024-03-23 出版日期:2024-10-31 发布日期:2024-10-31
通讯作者: 明良山

Recent developments in the physical structure of solid formulations: a comprehensive review

Zhe Li¹^,^#, Xiaosui Luo¹^,^#, Abid Naeem¹, Qiong Li¹, Yao Zhang², Yongmei Guan¹, Lihua Chen¹, Weifeng Zhu¹, Zhengji Jin¹, Yi Feng¹^,³, Liangshan Ming¹^,^*()

¹ Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China
² National Pharmaceutical Engineering Research Center for Solid Formulation in Chinese Herbal Medicine, Nanchang 330004, Jiangxi, China
³ Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received:2024-01-08 Revised:2024-02-12 Accepted:2024-03-23 Online:2024-10-31 Published:2024-10-31
Contact: Liangshan Ming
About author:
^# Zhe Li and Xiaosui Luo contributed equally to this work.
Supported by:
The National Natural Science Foundation of China (Grant No. 82003953, 82360777), the National Natural Science Foundation of Jiangxi Province (Grant No. 20232ACB216015), 2020–2022 Young Talents Support Project of Chinese Society of Chinese Medicine (Grant No. 2020-QNRC2-07), Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program (Grant No. CXTD-22004), and the Doctoral Research start-up Fund Project of Jiangxi University of Chinese Medicine (Grant No. 2021BSZR015 and 2022BSZR003).

摘要/Abstract

摘要：

固体制剂作为最广泛使用的剂型, 其结构显著影响药物的有效性。因此, 深入研究固体制剂结构是至关重要的。本文采用文献计量学的方法总结了近五年固体制剂和物理结构方面的文献, 并利用CiteSpace软件提供了可视化分析。此外, 在三个不同的水平上探讨了固体制剂结构的影响因素: 原材料、中间体和最终产品。最后, 深入讨论了固体制剂物理结构的各种表征技术, 如扫描电子显微镜、透射电子显微镜、X射线衍射、核磁共振、低场核磁共振、热分析和太赫兹等。本综述强调了固体制剂结构研究的重要意义, 为该领域的进一步研究和发展奠定了基础。这种全面的方法旨在促进固体制剂的理解和进步, 以提高药物的有效性。

关键词: 固体制剂, 物理结构, CiteSpace, 影响因素, 物理表征

Abstract:

Solid formulations represent the most widely used dosage forms, and their structural attributes significantly impact the efficacy of drugs. Consequently, delving into the study of solid formulation structures is of paramount importance. This paper employs bibliometrics to summarize references on solid formulations and physical structure over the past 5 years, providing a visual representation through CiteSpace. Additionally, we explore influential factors affecting the structure of solid formulations at three distinct levels: raw material, intermediate, and final product. It delves into the discussion of various characterization techniques employed to analyze the physical structure of solid formulations. The techniques include scanning electron microscopy, transmission electron microscopy, X-ray diffraction, nuclear magnetic resonance, LF-nuclear magnetic resonance, thermal analysis, and terahertz. Emphasis is placed on the significance of investigating formulation structures, serving as a found ational step for future research and development in this field. This comprehensive approach aims to contribute to the understanding and advancement of solid formulations for enhanced drug effectiveness.

Key words: Solid formulations, Physical structure, CiteSpace, Affecting factors, Physical characterization

Supporting:

李哲, 罗晓岁, Abid Naeem, 李琼, 张尧, 管咏梅, 陈丽华, 朱卫丰, 金正吉, 冯怡, 明良山. 固体制剂物理结构的研究进展[J]. 中国药学(英文版), 2024, 33(10): 877-905.

Zhe Li, Xiaosui Luo, Abid Naeem, Qiong Li, Yao Zhang, Yongmei Guan, Lihua Chen, Weifeng Zhu, Zhengji Jin, Yi Feng, Liangshan Ming. Recent developments in the physical structure of solid formulations: a comprehensive review[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(10): 877-905.

图/表 7

Table 1. The top eight most cited references.

Figure 1. A keyword co-occurrence visualization chart.

Figure 2. Timeline mapping of keywords for the physical structure of solid formulation.

Figure 3. The factors affecting the consistency of the physical structure of formulation products.

Figure 4. The factors affecting the consistency of the physical structure of the formulation intermediate.

Figure 5. The factors affecting the consistency of the physical structure of raw materials.

Table 2. The classification, characteristics, and characterization parameters of structural characterization techniques.

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固体制剂物理结构的研究进展

Recent developments in the physical structure of solid formulations: a comprehensive review

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