疏血通联合丁苯酞对急性缺血性脑卒中患者神经功能及炎症反应的影响

doi:10.5246/jcps.2024.03.019

中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (3): 241-247.DOI: 10.5246/jcps.2024.03.019

疏血通联合丁苯酞对急性缺血性脑卒中患者神经功能及炎症反应的影响

楼昆昂¹^,^#, 卢栋升¹^,^#, 潘奕杨¹^,^#, 乐言¹, 闫焕², 付浩³, 李银丹³^,^*(), 杨金姬³^,^*(), 曲苗⁴

^1. 浙江中医药大学, 浙江杭州 310053
^2. 重庆市人民医院, 重庆 400010
^3. 武警特色医学中心, 天津 300162
^4. 黑龙江中医药大学, 黑龙江哈尔滨 150006

收稿日期:2023-08-07 修回日期:2023-08-20 接受日期:2023-09-18 出版日期:2024-03-31 发布日期:2024-03-31
通讯作者: 李银丹, 杨金姬

Effects of Shuxuetong combined with butylphthalide on neurological function and inflammatory response in patients with acute ischemic stroke

Kunang Lou¹^,^#, Dongsheng Lu¹^,^#, Yiyang Pan¹^,^#, Yan Le¹, Huan Yan², Hao Fu³, Yindan Li³^,^*(), Jinji Yang³^,^*(), Miao Qu⁴

¹ Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
² Chongqing People’s Hospital, Chongqing 400010, China
³ Characteristic Medical Center of Chinese People’s Armed Police Forces, Tianjin 300162, China
⁴ Heilongjiang University of Traditional Chinese Medicine, Harbin 150006, Heilongjiang, China

Received:2023-08-07 Revised:2023-08-20 Accepted:2023-09-18 Online:2024-03-31 Published:2024-03-31
Contact: Yindan Li, Jinji Yang
About author:
^# Kunang Lou, Dongsheng Lu and Yiyang Pan contributed equally to this work.
Supported by:
Heilongjiang Traditional Chinese Medicine Research Project (Grant No. ZHY18-075).

摘要/Abstract

摘要：

为了观察疏血通联合丁苯酞对急性缺血性脑卒中(AIS)患者神经功能及炎症反的影响, 本研究以2019年6月~2020年6月住院的98例AIS患者为研究对象, 随机分为两组, 每组49例。对照组给予丁苯酞注射液治疗, 静脉滴注, 100 mL/次, 2次/天; 观察组在对照组基础上, 静脉滴注疏血通注射液, 6 mL溶于250 mL 5%的葡糖糖溶液中, 1次/天。两组均治疗14天。观察两组入院当天、治疗后7天、14天美国国立卫生院脑卒中量表(NIHSS)、改良Barthel指数(MBI)量表评分及血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、可溶性细胞间粘附分子(sICAM-1)水平变化, 并观察两组蒙特利尔认知评估量表(MoCA)和简易精神状态检查量表(MMSE)评分变化。治疗后两组NIHSS评分显著降低(P < 0.05), MBI评分显著升高(P < 0.05), 且治疗后7天、14天观察组NIHSS和MBI评分明显优于对照组(P < 0.05); 治疗后两组MoCA和MMSE评分均明显升高(P < 0.05), 且治疗后7天、14天观察组认知功能评分明显高于对照组(P < 0.05); 治疗后两组血清IL-6、TNF-α、CRP、sICAM-1水平均明显降低(P < 0.05), 且治疗后7天、14天观察组炎症因子水平明显低于对照组(P < 0.05)。提示疏血通联合丁苯酞治疗AIS患者可更好的促进神经功能恢复、提高生活能力, 减轻炎症反应, 改善认知功能, 具有很好的临床应用价值。

关键词: 疏血通, 丁苯酞, 急性缺血性脑卒中, 炎症反应, 认知功能

Abstract:

To investigate the effects of Shuxuetong combined with butylphthalide on neurological function and inflammation in patients with acute ischemic stroke (AIS), a total of 98 AIS patients admitted to the hospital between June 2019 and June 2020 were selected as the study subjects. They were randomly divided into two groups, with 49 patients in each group. The control group received treatment with butylphthalide injection, administered intravenously at a dosage of 100 mL per time, twice a day. On the basis of the control group, the observation group received additional intravenous injections of Shuxuetong injection, dissolved in 250 mL of 5% glucose solution, once a day. Both groups underwent a 14-d treatment period. The researchers assessed the National Institutes of Health Stroke Scale (NIHSS) scores, Modified Barthel Index (MBI) scores, and serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) on admission day, as well as on days 7 and 14 after treatment in both groups. Additionally, the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores were evaluated. After treatment, both groups showed a significant decrease in NIHSS scores (P < 0.05) and a significant increase in MBI scores (P < 0.05). Furthermore, the observation group exhibited significantly better NIHSS and MBI scores compared to the control group at 7 and 14 d after treatment (P < 0.05). The MoCA and MMSE scores significantly increased in both groups after treatment (P < 0.05), with the observation group demonstrating significantly higher cognitive function scores compared to the control group at 7 and 14 d after treatment (P < 0.05). Moreover, the levels of serum IL-6, TNF-α, CRP, and sICAM-1 significantly decreased in both groups after treatment (P < 0.05), with the observation group showing significantly lower levels of inflammatory markers compared to the control group at 7 and 14 d after treatment (P < 0.05). Based on these findings, it suggested that the combination of Shuxuetong and butylphthalide in the treatment of AIS patients could lead to better recovery of neurological function, improved life ability, reduced inflammation, and enhanced cognitive function. Therefore, this combined treatment approach held significant clinical value.

Key words: Shuxuetong, Butylphthalide, Acute ischemic stroke, Inflammatory response, Cognitive function

Supporting:

楼昆昂, 卢栋升, 潘奕杨, 乐言, 闫焕, 付浩, 李银丹, 杨金姬, 曲苗. 疏血通联合丁苯酞对急性缺血性脑卒中患者神经功能及炎症反应的影响[J]. 中国药学(英文版), 2024, 33(3): 241-247.

Kunang Lou, Dongsheng Lu, Yiyang Pan, Yan Le, Huan Yan, Hao Fu, Yindan Li, Jinji Yang, Miao Qu. Effects of Shuxuetong combined with butylphthalide on neurological function and inflammatory response in patients with acute ischemic stroke[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(3): 241-247.

图/表 4

Table 1. Comparison of basic admission conditions between the two groups.

Table 2. Comparison of neurological deficits and ADL scores between the two groups.

Table 3. Comparison of cognitive function scores between the two groups.

Table 4. Comparison of levels of inflammatory factors between the two groups.

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疏血通联合丁苯酞对急性缺血性脑卒中患者神经功能及炎症反应的影响

Effects of Shuxuetong combined with butylphthalide on neurological function and inflammatory response in patients with acute ischemic stroke

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