Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

doi:10.5246/jcps.2019.05.035

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (5): 360-368.DOI: 10.5246/jcps.2019.05.035

Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

Suryati^*, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari

Department of Chemistry, Faculty of Mathematics and Sciences, Andalas University, Padang 25163, Indonesia

收稿日期:2018-12-15 修回日期:2019-01-11 出版日期:2019-05-31 发布日期:2019-02-16
通讯作者: E-mail: suryati@sci.unand.ac.id

Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

Suryati^*, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari

Department of Chemistry, Faculty of Mathematics and Sciences, Andalas University, Padang 25163, Indonesia

Received:2018-12-15 Revised:2019-01-11 Online:2019-05-31 Published:2019-02-16
Contact: E-mail: suryati@sci.unand.ac.id

摘要/Abstract

摘要：

Two compounds with different bioactivitieswere isolated from the leaves of the Lantana camara Linn plant. Compound 1wastriterpenoid (Lantadene B)(22β-dimethylacroyloxy-3-oxoolean-12-en-28-oic-acid, C₃₅H₅₂O₅), which was isolatedfrom n-hexane fraction and obtained as white solid (amorphous). Compound 2was glycosideflavonoid (5-hydroxy-6,4′-dimethoxyflavon-7-O-glucopyranose, C₂₃H₂₄O₁₁), which was isolated from ethyl acetate and obtained as pale yellow solid (amorphous). Extraction was performed withmaceration method using methanol solvent. Subsequently, fractionation was carried out using n-hexane and ethyl acetate solvents. Isolation and purification of both fractions were conductedusing chromatography method. The structure of the isolated compounds was determined throughspectralanalyses of ultraviolet (UV), infrared (IR), and nuclear magnetic resonance (¹H NMR and ¹³C NMR), distortionless enhancement by polarization transfer (DEPT), heteronuclear multiple bond connectivity (HMBC), heteronuclear single quantum correlation (HSQC), and H-H COSY (¹H-¹H homonuclear correlatedspectroscopy). The cytotoxic activity of compound 1 was tested against MCF-7 breast cancer cellsin vitro using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), showing very strong cytotoxic activity in inhibiting the growth of MCF-7 breast cancer cells, and the IC₅₀ value was 1.1336 µM. The antioxidant activity of compound 2 was tested using DPPH assay (1,1-diphenyl-2-picrylhydrazyl), showing strong activity in inhibiting free radicals, and its IC₅₀ value was 71.03 mg/L.

关键词: Lantana camara Linn, Lantadene B, Glycosides flavonoid, MCF-7 breast cell cancer, Cytotoxic, Antioxidant activity

Abstract:

Key words: Lantana camara Linn, Lantadene B, Glycosides flavonoid, MCF-7 breast cell cancer, Cytotoxic, Antioxidant activity

中图分类号:

R284

Supporting:

Suryati, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari. Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant[J]. 中国药学(英文版), 2019, 28(5): 360-368.

Suryati, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari. Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(5): 360-368.

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Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

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