二甲基姜黄素类脂囊泡的制备工艺与质量评价

doi:10.5246/jcps.2017.04.027

中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (4): 265-270.DOI: 10.5246/jcps.2017.04.027

二甲基姜黄素类脂囊泡的制备工艺与质量评价

李蕊, 徐德锋, 杨幸群, 马守秀, 戈晓爱, 周舒文^*

常州大学制药与生命科学学院, 护理学院, 江苏常州 213164

收稿日期:2017-02-15 修回日期:2017-03-29 出版日期:2017-04-26 发布日期:2017-04-02
通讯作者: Tel.: +86-15189787780, E-mail: zhoushuwen@cczu.edu.cn
基金资助:
The National Natural Science Foundation of China (Grant No. 31271002), Jiangsu Provincial Department of Education Funded Projects (Grant No. 14KJB350001).

Preparation and stability studies of dimethyl curcumin niosomes

Rui Li, Defeng Xu, Xingqun Yang, Shouxiu Ma, Xiaoai Ge, Shuwen Zhou^*

School of Pharmaceutical Engineering and Life Science, School of Nursing, Changzhou university, Changzhou 213164, China

Received:2017-02-15 Revised:2017-03-29 Online:2017-04-26 Published:2017-04-02
Contact: Tel.: +86-15189787780, E-mail: zhoushuwen@cczu.edu.cn
Supported by:
The National Natural Science Foundation of China (Grant No. 31271002), Jiangsu Provincial Department of Education Funded Projects (Grant No. 14KJB350001).

摘要/Abstract

摘要：

本研究的目的是优化二甲基姜黄素类脂囊泡的制备工艺,提高二甲基姜黄素溶解度,并考察二甲基姜黄素类脂囊泡的稳定性。通过薄膜分散法制备负载二甲基姜黄素类脂囊泡,采用单因素考察法优化处方组成和制备工艺,探究其溶解性并进行质量评价。工艺优化后制备的二甲基姜黄色素类脂囊泡的平均粒径为(310.3±0.9) nm,包封率为(88.1±1.7)%,载药量为(4.03±1.05)%,渗漏率在45天内低于2%。这些发现均表明类脂囊泡作为二甲基姜黄素的载体显著提高其溶解度,并有很好的稳定性,使得二甲基姜黄素作为抗癌药物在药物应用中具有很好的应用前景。

关键词: 类脂囊泡, 二甲基姜黄素, 薄膜分散法, 包封率, 质量评价

Abstract:

In the present work, we aimed to optimize the preparation technology of dimethyl curcumin niosomes, improve its solubility and assess its stability. The novel anti-androgen dimethyl curcuminniosomes were prepared by thin-film dispersion-ultrasonic method, and the prescription composition and preparation process were optimized by single-factor investigation method. Certainly, the solubility and quality evaluation of dimethyl curcumin niosomes were also investigated. The average particle size of prepared dimethyl curcumin niosomes was (310.3±0.9) nm. The highest encapsulation rate was 88.1%±1.7%, and the drug-loading amount was 4.03%±1.05%. Moreover, the leakage rate was below 2% within 45 d. Collectively, all these findings indicated that the niosomes, as a vector, could significantly improve the solubility and stability of dimethyl curcumin, offering a theoretical basis for dimethyl curcumin as an anticancer drug in medicine application.

Key words: Niosomes, Dimethyl curcumin, Thin-film dispersion-ultrasonic method, Encapsulation efficiency, Quality evaluation

中图分类号:

R944.9

Supporting:

李蕊, 徐德锋, 杨幸群, 马守秀, 戈晓爱, 周舒文. 二甲基姜黄素类脂囊泡的制备工艺与质量评价[J]. 中国药学(英文版), 2017, 26(4): 265-270.

Rui Li, Defeng Xu, Xingqun Yang, Shouxiu Ma, Xiaoai Ge, Shuwen Zhou. Preparation and stability studies of dimethyl curcumin niosomes[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(4): 265-270.

参考文献

[1] Fuentes, F.; Gomez, Y.; Paredes-Gonzalez, X.; Barve, A.; Nair, S.; Yu, S.; Saw, C.L.L.; Kong, Ah-Ng T. J. Chin. Pharm. Sci. 2016, 25, 559-569.

[2] Zhou, D.Y.; Zhao, S.Q.; Zheng, X.; Du, Z.Y.; Zhang, K. J. Chin. Pharm. Sci. 2015, 24, 524-529.

[3] Wei, X.C.; Du, Z.Y.; Zheng, X.; Cui, X.X.; Conney, A.H.; Zhang, K. Eur. J. Med. Chem. 2012, 53, 235-245.

[4] Yamashita, S.; Lai, K.P.; Chuang, K.L.; Xu, D.; Miyamoto, H.; Tochiqi, T.; Pang, S.T.; Li, L.; Arai, Y.; Kung, H.J.; Yeh, S.; Chang, C. Neoplasia. 2012, 14, 74-83.

[5] Wahajuddin.; Singh, S.P.; Jain, G.K. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2010, 2, 1133-1139.

[6] Li, R.; Qiao, X.; Li, Q.; He, R.; Ye, M.; Xiang, C.; Lin, X.; Guo, D. J. Chromatogr B. Analyt. Technol. Biomed. Life Sci. 2011, 879, 2751-2758.

[7] Tamvakopoulos, C.; Dimas, K.; Sofianos, Z.D.; Hatziantoniou, S.; Han, Z.; Liu, Z.L.; Wyche, J.H.; Pantazis, P. Clin. Cancer Res. 2007, 13, 1269-1277.

[8] Lai, K.P.; Huang, C.K.; Chang, Y.J.; Chung, C.Y.; Yamashita, S.; Li, L.; Lee, S.O.; Yeh, S.; Chang, C. Am. J. Pathol. 2013, 182, 460-473.

[9] Anand, P.; Sundaram, C.; Jhurani, S.; Kunnumakkara, A.B.; Aqqarwal, B.B. Cancer Lett. 2008, 267, 133-164.

[10] Adams, B.K.; Ferstl, E.M.; Davis, M.C.; Herold, M.; Kurtkaya, S.; Camalier, R.F.; Hollingshead, M.G.; Kaur, G.; Sausville, E.A.; Rickles, F.R.; Snyder, J.P.; Liotta, D.C.; Shoji, M. Bioorg. Med. Chem. 2004, 12, 3871-3883.

[11] Sharma, V.; Anandhakumar, S.; Sasidharan, M. Mat. Sci. Eng. C-Mater. Biol. Appl. 2015, 56, 393-400.

[12] Vyas, S.P.; Singh, R.P.; Jain, S.; Mishra, V.; Mahor, S.; Singh, P.; Gupta, P.N.; Rawat, A.; Dubey, P. Int. J. Pharm. 2005, 296, 80-86.

[13] Baillie, A.J.; Florence, A.T.; Hume, L.R.; Muirhead, G.T.; Rogerson, A. J. Pharma. Pharmacol. 1985, 37, 863-868.

[14] Ren, W.; Zhang, S.; Zhong, T.; Huang, D.; Yao, X.; Guo, Y.; Duan, X.; Yin, Y.; Zhang, X. J. Chin. Pharm. Sci. 2016, 25, 570-575.

[15] Agarwal, R.; Katare, O.P.; Vyas, S.P. Int. J. Pharm. 2001, 228, 43-52.

[16] Zhu, K.C.; Cao G.Y.; Hu, X. J. Chin. Pharm. Sci. 2012, 21, 205-210.

[17] Ding, P.; Xu, H.; Zheng, J. J. Chin. Pharm. Sci., 2000, 9, 88-91.

[18] Liao, Z.G.; Han, X.Z.; Li, X.; Zhang, J.; Luo, Y.; Zhao, H.P.; Ni, B.; Liang, X.L.; Zhao, G.W. J. Chin. Pharm. Sci. 2013, 48, 899-903.

[19] Chen, H.X.; Xu, Z.J.; Xiao, Y.Y. J. Chin. Pharm. Sci. 2011, 42, 33-36.

二甲基姜黄素类脂囊泡的制备工艺与质量评价

Preparation and stability studies of dimethyl curcumin niosomes

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 13

编辑推荐

Metrics

本文评价

[1]	贾玮娟, 陈世忠, 孙建华, 白宗利, 黄亚卓, 张元宽, 王弘. 基于HPLC特征图谱与指纹图谱分析的中药猪苓质量评价研究[J]. 中国药学(英文版), 2020, 29(12): 896-907.
[2]	焦豪妍, 徐胜梅, 范春林, 张庆文, 王英. 高良姜指纹图谱的建立及主要成分的定量分析[J]. 中国药学(英文版), 2019, 28(10): 728-738.
[3]	赵一懿, 郭洪祝, 陈有根, 傅欣彤. 基于UPLC-QTOF-MSE 的代谢组学方法研究三七皂苷提取物及注射液的化学组分[J]. 中国药学(英文版), 2017, 26(5): 335-345.
[4]	王利群, 谢晓慧, 周瑞瑞. 我国大陆期刊哮喘药学服务随机对照研究的质量评价[J]. 中国药学(英文版), 2017, 26(3): 212-221.
[5]	李宁, 车彦云, 张梁, 张加余, 周渊, 姜勇, 屠鹏飞^*. HPLC-UV-ELSD结合化学计量学方法研究麦冬的指纹图谱[J]. , 2013, 22(1): 55-63.
[6]	张梁, 李宁, 车彦云, 马治中, 屠鹏飞^*. 普洱熟茶和普洱生茶的指纹图谱研究[J]. , 2011, 20(4): 352-359.
[7]	陈虎彪^*, 易涛. 香港中药材标准的制订与发展[J]. , 2010, 19(2): 87-94.
[8]	向蓉, 陈世武, 张辅民, 倪京满^*, 田瑄. HPLC法测定一种新型鬼臼毒素衍生物脂质体的包封率[J]. , 2009, 18(2): 186-189.
[9]	刘靖, 陈虎彪^*, 杜新刚, 赵中振, 王邠, 赵玉英, 易涛 . 不同来源中药黄芪的质量评价 [J]. , 2009, 18(1): 14-19.
[10]	郑国华^#, 王桂红^#, 吴木琴, 黄志军, 陶君彦^*, 张晓昱, 张琼光, 肖飞, 李崇明 . 草木樨药材指纹图谱研究 [J]. , 2009, 18(1): 20-29.
[11]	潘妍^*, 李英剑, 赵会英, 郝劲松, 郑俊民. 胰岛素壳聚糖纳米粒的制备及影响包封率因素的考察[J]. , 2002, 11(3): 97-100.
[12]	潘妍^*, 赵会英, 徐晖, 魏刚, 郝劲松, 郑俊民. 复乳法制备胰岛素PLGA纳米粒影响包封率因素考察[J]. , 2002, 11(1): 38-41.
[13]	张华, 齐宪荣, 张强^*. 柔红霉素隐形脂质体的药剂学性质[J]. , 2001, 10(4): 200-202.