临床药师干预对甲状腺手术围术期预防应用抗菌药物的影响

doi:10.5246/jcps.2015.09.078

中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (9): 617-624.DOI: 10.5246/jcps.2015.09.078

临床药师干预对甲状腺手术围术期预防应用抗菌药物的影响

朱愿超^1*, 胡永芳^2,3*, 杨莉萍¹, 胡欣¹

1. 卫生部北京医院药学部药物临床风险与个体化应用评价北京市重点实验室, 北京 100730
2. 北京清华长庚医院药剂科, 北京 102218
3. 北京大学第三医院药剂科, 北京 100191

收稿日期:2015-05-14 修回日期:2015-05-28 出版日期:2015-09-18 发布日期:2015-06-25
通讯作者: Tel.: 86-10-85133637, 13718106819, 13811172632, E-mail: yczhu-2009@163.com, hhyx66@163.com

Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

Yuanchao Zhu^1*, Yongfang Hu^2,3*, Liping Yang¹, Xin Hu¹

1. Department of Pharmacy, Beijing Hospital, Assessment of Clinical Drugs Risk and Individual Application Key Laboratory, Beijing 100730, China
2. Department of Pharmacy, Beijing Tsinghua Chang Gung Hospital, Beijing 102218, China
3. Department of Pharmacy, Peking University Third Hospitail, Beijing 100191, China

Received:2015-05-14 Revised:2015-05-28 Online:2015-09-18 Published:2015-06-25
Contact: Tel.: 86-10-85133637, 13718106819, 13811172632, E-mail: yczhu-2009@163.com, hhyx66@163.com

摘要/Abstract

摘要：

本研究评估了临床药师干预前后某大医院甲状腺手术预防性抗菌药物的使用情况。自2004年至2012年, 随机抽取每年的70例接受甲状腺手术的患者病历, 评价干预前后手术预防性应用抗菌药物的合理性。研究结果表明, 从2004年到2010年抗菌药物使用率一直是100%。实施干预后, 2011年使用率降到45.7%, 2012年降到2.9%。2010年之前的AUD一直大于38, 2012年迅速下降到1。每100个手术的DDDs由干预前的143降至3。2010年抗菌药物的平均费用为350.65元, 2012年降至18.51元。干预前后患者平均住院天数没有区别。结果表明, 临床药师的干预和专项整治的实施能改善围手术期抗菌药物的合理使用。

关键词: 甲状腺手术, 临床药师, 围手术期抗菌药物使用, DDDs, AUD

Abstract:

In the present study, we aimed to evaluate the intervention effect of prophylactic antibiotic use in thyroid surgery in a largehospital. From 2004 to 2012, 70 patients who underwent thyroid surgery were randomly selected each year. The quality of surgical antibiotic prophylaxis (SAP) was assessed each year in terms of antibiotic ratio, choice, duration, timing, combination, route of administration and so on. The result showed that the SAP ratio was 100% from 2004 to 2010. With our intervention, this SAP ratio was decreased to 45.7% in 2011, and it reached 2.9% in 2012. The AUD was consistently greater than 38 before 2010, while it rapidly declined to 1 in 2012. The number of DDDs per 100 operations was decreased from 431 to 3 after the intervention. The average cost of antibiotic drugs per patient was RMB 350.65 in 2010, whereas it was decreased to RMB 18.51 in 2012. The average duration of hospitalization showed no difference during the intervention. This study indicated that implementation of a multi-disciplinary protocol and clinical pharmacist interventions could improve the rational use of SAP.

Key words: Thyroid surgery, Clinical pharmacist, Surgical antibiotic prophylaxis, DDDs, AUD

中图分类号:

R969.3

Supporting:

朱愿超, 胡永芳, 杨莉萍, 胡欣. 临床药师干预对甲状腺手术围术期预防应用抗菌药物的影响[J]. 中国药学(英文版), 2015, 24(9): 617-624.

Yuanchao Zhu, Yongfang Hu, Liping Yang, Xin Hu. Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(9): 617-624.

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临床药师干预对甲状腺手术围术期预防应用抗菌药物的影响

Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

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