棉团铁线莲黄酮类成分研究

棉团铁线莲黄酮类成分研究

董彩霞, 武可泗, 史社坡, 屠鹏飞^*

1.陕西中医学院药学系, 陕西咸阳 712046;
2.北京大学药学院, 北京 100083

收稿日期:2005-11-17 修回日期:2006-02-10 出版日期:2006-03-15 发布日期:2006-03-15
通讯作者: 屠鹏飞*

Flavanoids from Clematis hexapetala

DONG Cai-xia, WU Ke-si, SHI She-po, TU Peng-fei^*

1.Department of Pharmaceutical Sciences, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China;
2.School of Pharmaceutical Sciences, Peking University, Beijing 100083, China

Received:2005-11-17 Revised:2006-02-10 Online:2006-03-15 Published:2006-03-15
Contact: TU Peng-fei*

摘要/Abstract

摘要： 目的研究棉团铁线莲Clematis hexapetala Pall.的干燥根及根茎的化学成分。方法利用溶剂提取, 硅胶柱色谱和高效液相色谱等手段进行分离、纯化, 根据理化性质和波谱数据进行结构鉴定。结果分离鉴定了12个黄酮类化合物,分别为3,5,6,7,8,3',4'-七甲氧基黄酮(1), nobiletin(2), liquiritigenin(3), 橙皮素(4), 柚皮素(5), 7,4'-二羟基-二氢黄酮-7-O-β-D-葡萄糖苷(6), 5,7,4'-三羟基-3'-甲氧基黄酮醇-7-O-α-L-鼠李糖(1→6)-β-D-葡萄糖苷(7), 6-hydroxybiochainA(8), 芒柄花素(9), 大豆素(10), 染料木素(11), 鸢尾苷(12)。结论以上化合物均为首次从该植物中分离得到。,

关键词: 棉团铁线莲, 棉团铁线莲, 棉团铁线莲, 黄酮, 黄酮, 黄酮, 结构鉴定, 结构鉴定, 结构鉴定

Abstract: Aim To study the chemical constituents from the roots and rhizomes of Clematis hexapetala Pall. Methods The components were isolated by means of solvent extraction, repeated chromatography with silica gel, sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Results Twelve flavonoids were isolated and their structures were identified as 3, 5, 6, 7, 8, 3', 4'-heptamethoxyflavone (1), nobiletin (2), liquiritigenin (3), hesperetin (4), naringenin (5), liquiritigen-7-O-β-D-glucopyranoside (6), 5, 7, 4'-trihydroxy-3'-methoxyflavanone-7-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (7), 6-hydroxybiochain A (8), formononetin (9), daidzein (10), genistein (11), and tectoridin (12). Conclusion All the said compounds were isolated from the plant for the first time.

Key words: Clematis hexapetala Pall., Clematis hexapetala Pall., flavonoids, flavonoids, structure determination, structure determination

中图分类号:

R284.1

R284.2

Supporting: Foundation item: National Natural Science Foundation of China (2004AA2Z3730).
^*Corresponding author. Tel.: 86-10-82802750

董彩霞, 武可泗, 史社坡, 屠鹏飞^*. 棉团铁线莲黄酮类成分研究[J]. .

DONG Cai-xia, WU Ke-si, SHI She-po, TU Peng-fei^*. Flavanoids from Clematis hexapetala[J]. .

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