Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice

doi:10.5246/jcps.2016.03.020

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (3): 170-177.DOI: 10.5246/jcps.2016.03.020

• 【传统中药和植物药的癌症预防专栏】 • 上一篇下一篇

Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice

Ying Huang, Zhengyuan Su, Tienyuan Wu, Constance Lay-Lay Saw, Ah-Ng Tony Kong^*

Department of Pharmaceutics, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

收稿日期:2015-10-27 修回日期:2015-11-17 出版日期:2016-03-29 发布日期:2015-12-12
通讯作者: Tel.: 848-445-6369, Fax: 732-445-3134, E-mail: KongT@pharmacy.rutgers.edu
基金资助:
Institutional Funds and by R01-CA118947, R01-CA152826, from the National Cancer Institute (NCI), R01AT007065 from the National Center for Complementary and Alternative Medicines (NCCAM) and the Office of Dietary Supplements (ODS).

Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice

Ying Huang, Zhengyuan Su, Tienyuan Wu, Constance Lay-Lay Saw, Ah-Ng Tony Kong^*

Department of Pharmaceutics, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Received:2015-10-27 Revised:2015-11-17 Online:2016-03-29 Published:2015-12-12
Contact: Tel.: 848-445-6369, Fax: 732-445-3134, E-mail: KongT@pharmacy.rutgers.edu
Supported by:
Institutional Funds and by R01-CA118947, R01-CA152826, from the National Cancer Institute (NCI), R01AT007065 from the National Center for Complementary and Alternative Medicines (NCCAM) and the Office of Dietary Supplements (ODS).

摘要/Abstract

摘要：

Tocopherols belong to a subgroup of the vitamin E family. Dietary feeding of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) inhibits prostate tumorigenesis in TRAMP mice. In this study, we aimed to investigate mechanisms of prostate carcinogenesis in TRAMP mice by identifying differentially expressed pathways and effects of γ-TmT on these pathways. Eight-week-old TRAMP and age-matched C57BL/6 mice were administered either 600 mg/kg of γ-TmT or a control vehicle via oral gavage. Twelve hours after dosing, prostate tissues were collected for RNA extraction. Whole genome mouse microarrays were used to examine gene expression profiles. The expression of the selected genes were validated using quantitative PCR. Thousands of genes and various pathways were altered in the prostates of TRAMP mice. Compared to C57BL/6 mice, TRAMP mice exhibited enhanced proliferation, suppressed expression of antioxidant and phase II detoxification enzymes, and metabolic reprogramming in the prostate. γ-TmT differentially regulated the gene expression profiles of TRAMP and C57BL/6 mice, with only a small percentage of genes overlapping. γ-TmT inhibited genes involved in proliferation and glucose metabolism and induced several antioxidant/phase II detoxification genes in TRAMP mice. γ-TmT modulates multiple aberrant pathways in the prostate of TRAMP mice, which might represent important mechanisms for prostate cancer prevention.

关键词: Tocopherol, Vitamin E, Prostate cancer, Proliferation, Antioxidant, Glucose metabolism

Abstract:

Key words: Tocopherol, Vitamin E, Prostate cancer, Proliferation, Antioxidant, Glucose metabolism

中图分类号:

R962

Supporting:

Ying Huang, Zhengyuan Su, Tienyuan Wu, Constance Lay-Lay Saw, Ah-Ng Tony Kong. Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice[J]. 中国药学(英文版), 2016, 25(3): 170-177.

参考文献

[1] Brigelius-Flohe, R.; Traber, M.G. FASEB J. 1999, 13, 1145-1155.

[2] Frei, B. J. Nutr. 2004, 134, 3196S-3198S.

[3] Jiang, Q.; Elson-Schwab, I.; Courtemanche, C.; Ames, B.N. Proc. Natl. Acad. Sci. USA. 2000, 97, 11494-11499.

[4] Jiang, Q.; Ames, B.N. FASEB J. 2003, 17, 816-822.

[5] Jiang, Q.; Wong, J.; Ames, B.N. Ann. NY. Acad. Sci. 2004, 1031, 399-400.

[6] Yu, W.; Simmons-Menchaca, M.; Gapor, A.; Sanders, B.G.; Kline, K. Nutr. Cancer. 1999, 33, 26-32.

[7] Barve, A.; Khor, T.O.; Nair, S.; Reuhl, K.; Suh, N.; Reddy, B.; Newmark, H.; Kong, A.N. Int. J. Cancer. 2009, 124, 1693-1699.

[8] Huang, Y.; Khor, T.O.; Shu, L.; Saw, C.L.; Wu, T.Y.; Suh, N.; Yang, C.S.; Kong, A.N. J. Nutr. 2012, 142, 818-823.

[9] Zheng, X.; Cui, X.X.; Khor, T.O.; Huang, Y.; Dipaola, R.S.; Goodin, S.; Lee, M.J.; Yang, C.S.; Kong, A.N.; Conney, A.H. Cancers (Basel). 2011, 3, 3762-3772.

[10] Li, G.X.; Lee, M.J.; Liu, A.B.; Yang, Z.; Lin, Y.; Shih, W.J.; Yang, C.S. Cancer Prev. Res (Phila). 2011, 4, 404-413.

[11] Guan, F.; Li, G.; Liu, A.B.; Lee, M.J.; Yang, Z.; Chen, Y.K.; Lin, Y.; Shih, W.; Yang, C.S. Cancer Prev. Res (Phila). 2012, 5, 644-654.

[12] Jiang, Q.; Jiang, Z.; Hall, Y.J.; Jang, Y.; Snyder, P.W.; Bain, C.; Huang, J.; Jannasch, A.; Cooper, B.; Wang, Y.; Moreland, M. Free Radic. Biol. Med. 2013, 65, 1069-1077.

[13] Takahashi, S.; Takeshita, K.; Seeni, A.; Sugiura, S.; Tang, M.; Sato, S.Y.; Kuriyama, H.; Nakadate, M.; Abe, K.; Maeno, Y.; Nagao, M.; Shirai, T. Prostate. 2009, 69, 644-651.

[14] Smolarek, A.K.; So, J.Y.; Burgess, B.; Kong, A.N.; Reuhl, K.; Lin, Y.; Shih, W.J.; Li, G.; Lee, M.J.; Chen, Y.K.; Yang, C.S.; Suh, N. Cancer Prev. Res. (Phila). 2012, 5, 1310-1320.

[15] Lee, H.J.; Ju, J.; Paul, S.; So, J.Y.; DeCastro, A.; Smolarek, A.; Lee, M.J.; Yang, C.S.; Newmark, H.L.; Suh, N. Clin. Cancer Res. 2009, 15, 4242-4249.

[16] Siegel, R.; Naishadham, D.; Jemal, A. CA Cancer J. Clin. 2013, 63, 11-30.

[17] Ju, J.; Picinich, S.C.; Yang, Z.; Zhao, Y.; Suh, N.; Kong, A.N.; Yang, C.S. Carcinogenesis. 2010, 31, 533-542.

[18] Heinonen, O.P.; Albanes, D.; Virtamo, J.; Taylor, P.R.; Huttunen, J.K.; Hartman, A.M.; Haapakoski, J.; Malila, N.; Rautalahti, M.; Ripatti, S.; Maenpaa, H.; Teerenhovi, L.; Koss, L.; Virolainen, M.; Edwards, B.K. J. Natl. Cancer Inst. 1998, 90, 440-446.

[19] Lippman, S.M.; Klein, E.A.; Goodman, P.J.; Lucia, M.S.; Thompson, I.M.; Ford, L.G.; Parnes, H.L.; Minasian, L.M.; Gaziano, J.M.; Hartline, J.A.; Parsons, J.K.; Bearden, J.D., 3rd; Crawford, E.D.; Goodman, G.E.; Claudio, J.; Winquist, E.; Cook, E.D.; Karp, D.D.; Walther, P.; Lieber, M.M.; Kristal, A.R.; Darke, A.K.; Arnold, K.B.; Ganz, P.A.; Santella, R.M.; Albanes, D.; Taylor, P.R.; Probstfield, J.L.; Jagpal, T.J.; Crowley, J.J.; Meyskens, F.L.,Jr.; Baker, L.H.; Coltman, C.A.Jr. JAMA. 2009, 301, 39-51.

[20] Gaziano, J.M.; Glynn, R.J.; Christen, W.G.; Kurth, T.; Belanger, C.; MacFadyen, J.; Bubes, V.; Manson, J.E.; Sesso, H.D.; Buring, J.E. JAMA. 2009, 301, 52-62.

[21] Jiang, Q.; Christen, S.; Shigenaga, M.K.; Ames, B.N. Am. J. Clin. Nutr. 2001, 74, 714-722.

[22] Wu, T.Y.; Khor, T.O.; Su, Z.Y.; Saw, C.L.; Shu, L.; Cheung, K.L.; Huang, Y.; Yu, S.; Kong, A.N. AAPS J. 2013, 15, 864-874.

[23] Opoku-Acheampong, A.B.; Unis, D.; Henningson, J.N.; Beck, A.P.; Lindshield, B.L. PLoS One. 2013, 8, e77738.

[24] Shukla, S.; Bhaskaran, N.; Babcook, M.A.; Fu, P.; Maclennan, G.T.; Gupta, S. Carcinogenesis. 2013, 279-281.

[25] Hahm, E.R.; Karlsson, A.I.; Bonner, M.Y.; Arbiser, J.L.; Singh, S.V. Prostate. 2013, 315-327.

[26] Keum, Y.S.; Khor, T.O.; Lin, W.; Shen, G.; Kwon, K.H.; Barve, A.; Li, W.; Kong, A.N. Pharm. Res. 2009, 26, 2324-2331.

[27] Ru, P.; Steele, R.; Nerurkar, P.V.; Phillips, N.; Ray, R.B. Cancer Prev. Res. (Phila). 2011, 4, 2122-2130.

[28] Wu, T.Y.; Saw, C.L.; Khor, T.O.; Pung, D.; Boyanapalli, S.S.; Kong, A.N. Mol. Carcinog. 2012, 51, 761-770.

[29] Greenberg, N.M.; DeMayo, F.; Finegold, M.J.; Medina, D.; Tilley, W.D.; Aspinall, J.O.; Cunha, G.R.; Donjacour, A.A.; Matusik, R.J.; Rosen, J.M. Proc. Natl. Acad. Sci. USA. 1995, 92, 3439-3443.

[30] Barve, A.; Khor, T.O.; Nair, S.; Lin, W.; Yu, S.; Jain, M.R.; Chan, J.Y.; Kong, A.N. J. Pharm. Sci. 2008, 97, 4528-4545.

[31] Nair, S.; Xu, C.; Shen, G.; Hebbar, V.; Gopalakrishnan, A.; Hu, R.; Jain, M.R.; Liew, C.; Chan, J.Y.; Kong, A.N. Toxicol. Lett. 2007, 168, 21-39.

[32] Khor, T.O.; Hu, R.; Shen, G.; Jeong, W.S.; Hebbar, V.; Chen, C.; Xu, C.; Nair, S.; Reddy, B.; Chada, K.; Kong, A.N. . 2006, 27, 407-420.Biopharm. Drug Dispos

[33] Bolstad, B.M.; Irizarry, R.A.; Astrand, M.; Speed, T.P. Bioinformatics. 2003, 19, 185-193.

[34] Laurent, G.; Leslie, C.; Bolstad, B.M.; Irizarry, R.A. Bioinformatics. 2004, 3, 307-315.

[35] Su, Z.Y.; Shu, L.; Khor, T.O.; Lee, J.H.; Fuentes, F.; Kong, A.N. Top. Curr. Chem. 2013, 329, 133-162.

[36] Slocum, S.L.; Kensler, T.W. Arch. Toxicol. 2011, 85, 273-284.

[37] Hayes, J.D.; Flanagan, J.U.; Jowsey, I.R. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 51-88.

[38] Hanahan, D.; Weinberg, R.A. Cell. 2011, 144, 646-674.

[39] Nilsson, U.; Meshalkina, L.; Lindqvist, Y.; Schneider, G. J. Biol. Chem. 1997, 272, 1864-1869.

[40] Kahn, A.; Meienhofer, M.C.; Cottreau, D.; Lagrange, J.L.; Dreyfus, J.C. Hum. Genet. 1979, 48, 93-108.

[41] Elshourbagy, N.A.; Near, J.C.; Kmetz, P.J.; Wells, T.N.; Groot, P.H.; Saxty, B.A.; Hughes, S.A.; Franklin, M.; Gloger, I.S. Eur. J. Biochem. 1992, 204, 491-499.

[42] Tatibana, M.; Kita, K.; Taira, M.; Ishijima, S.; Sonoda, T.; Ishizuka, T.; Iizasa, T.; Ahmad, I. Adv. Enzyme Regul. 1995, 35, 229-249.

[43] Kim, Y.O.; Oh, I.U.; Park, H.S.; Jeng, J.; Song, B.J.; Huh, T.L. Biochem. J. 1995, 308 (Pt 1), 63-68.

[44] Eng, C.; Kiuru, M.; Fernandez, M.J.; Aaltonen, L.A. Nat. Rev. Cancer. 2003, 3, 193-202.

[45] Torricelli, P.; Caraglia, M.; Abbruzzese, A.; Beninati, S. Amino Acids. 2013, 44, 45-51.

[46] Ni, J.; Chen, M.; Zhang, Y.; Li, R.; Huang, J.; Yeh, S. Biochem. Biophys. Res. Commun. 2003, 300, 357-363.

[47] Gysin, R.; Azzi, A.; Visarius, T. FASEB J. 2002, 16, 1952-1954.

[48] Sigounas, G.; Anagnostou, A.; Steiner, M. Nutr. Cancer. 1997, 28, 30-35.

[49] Zheng, X.X.C.; Tin, O.K.; Ying, H.; Robert, S.D.; Susan, G.; Lee, M.J.; Chung, S.Y.; Ah-Ng, K.; Allan H, Conney. Cancer. 2011, 3, 3762-3772.

[50] Tam, N.N.; Nyska, A.; Maronpot, R.R.; Kissling, G.; Lomnitski, L.; Suttie, A.; Bakshi, S.; Bergman, M.; Grossman, S.; Ho, S.M. Prostate. 2006, 66, 57-69.

[51] Frohlich, D.A.; McCabe, M.T.; Arnold, R.S.; Day, M.L. Oncogene. 2008, 27, 4353-4362.

[52] Mavis, C.K.; Morey Kinney, S.R.; Foster, B.A.; Karpf, A.R. Prostate. 2009, 69, 1312-1324.

[53] Yu, S.; Khor, T.O.; Cheung, K.L.; Li, W.; Wu, T.Y.; Huang, Y.; Foster, B.A.; Kan, Y.W.; Kong, A.N. PLoS One. 2010, 5, e8579.

[54] Finkel, T. J. Cell Biol. 2011, 194, 7-15.

[55] Fryer, A.A.; Ramsay, H.M.; Lovatt, T.J.; Jones, P.W.; Hawley, C.M.; Nicol, D.L.; Strange, R.C.; Harden, P.N. Carcinogenesis. 2005, 26, 185-191.

[56] Carlsten, C.; Sagoo, G.S.; Frodsham, A.J.; Burke, W.; Higgins, J.P. Am. J. Epidemiol. 2008, 167, 759-774.

[57] Ward, P.S.; Thompson, C.B. Cancer Cell. 2012, 21, 297-308.

[58] Warburg, O. Science. 1956, 123, 309-314.

[59] Reiter, E.; Jiang, Q.; Christen, S. Mol. Aspects Med. 2007, 28, 668-691.

Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice

Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherol-rich mixture of tocopherols in TRAMP mice

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 9

编辑推荐

Metrics

本文评价

[1]	Suryati, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari. Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant[J]. 中国药学(英文版), 2019, 28(5): 360-368.
[2]	Tengku Siti Hajar Haryuna, Agustinus Hamonangan Winston Purba, Farhat Farhat, Soehartono Taat Putra. The effect of curcumin as an antioxidant on cochlea fibroblasts in ototoxic rat models[J]. 中国药学(英文版), 2018, 27(12): 847-854.
[3]	Asia Abed Al-Mahmood, Limin Shu, Hyuck Kim, Christina Ramirez, Douglas Pung, Yue Guo, Wenji Li, Ah-Ng Tony Kong. Prostate cancer and chemoprevention by natural dietary phytochemicals[J]. 中国药学(英文版), 2016, 25(9): 633-650.
[4]	Francisco Fuentes, Yury Gomez, Ximena Paredes-Gonzalez, Avantika Barve, Sujit Nair, Siwang Yu, Constance Lay Lay Saw, Ah-Ng Tony Kong. Nrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphane[J]. 中国药学(英文版), 2016, 25(8): 559-569.
[5]	Sujit Nair, Ah-Ng Tony Kong. Pharmacometrics of nutraceutical sulforaphane and its implications in prostate cancer prevention[J]. 中国药学(英文版), 2016, 25(1): 12-22.
[6]	Sujit Nair, Celine Liew, Tin-Oo Khor, Li Cai, Ah-Ng Tony Kong. Elucidation of regulatory interaction networks underlying human prostate adenocarcinoma[J]. 中国药学(英文版), 2015, 24(1): 12-27.
[7]	Sujit Nair, Celine Liew, Tin Oo Khor, Li Cai, Ah-Ng Kong . Differential signaling regulatory networks governing hormone refractory prostate cancers[J]. 中国药学(英文版), 2014, 23(8): 511-524.
[8]	Raj K. Keservani, Anil K. Sharma. Flavonoids: emerging trends and potential health benefits[J]. 中国药学(英文版), 2014, 23(12): 815-822.
[9]	Housam Haj Hamdo, Zaid Al-Assaf, Warid Khayata . Determination of the antioxidant activity based on the content changes in fatty acid methyl esters in vegetable oils[J]. 中国药学(英文版), 2014, 23(12): 873-877.