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中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (6): 435-445.DOI: 10.5246/jcps.2023.06.037

• 【研究论文】 • 上一篇    下一篇

牡蛎肽通过NF-κB/iNOS信号通路改善肝纤维化

邓凯翔1, 彭经宙2, 张美泉3, 林慧娟1, 王小华1, 何道兴1, 朱俊明1, 陈明光1, 黄津4,*()   

  1. 1. 福建医科大学附属南平第一医院, 福建 南平 353006
    2. 杭州市萧山区第一人民医院 感染性疾病科, 浙江 杭州 311200
    3. 福建省老年医院 呼吸与危重症医学科, 福建 福州 350003
    4. 福建中医药大学附属第二人民医院 感染科, 福建 福州 350003
  • 收稿日期:2022-12-07 修回日期:2023-01-21 接受日期:2023-02-16 出版日期:2023-07-01 发布日期:2023-07-01
  • 通讯作者: 黄津
  • 作者简介:
    + Tel.: +86-13859369873, E-mail:
  • 基金资助:
    The Project of Youth Foundation of Fujian Province Health Department (Grant No. 2020QNB053).

Oyster peptide ameliorates hepatic fibrosis through the NF-κB/iNOS signaling pathway

Kaixiang Deng1, Jingzhou Peng2, Meiquan Zhang3, Huijuan Lin1, Xiaohua Wang1, Daoxing He1, Junming Zhu1, Mingguang Chen1, Jin Huang4,*()   

  1. 1 The First Hospital of Nanping affiliated with Fujian Medical University, The First Hospital of Nanping Affiliated to Fujian Medical University, Nanping 353006, China
    2 Department of Infectious Diseases, The First People’s Hospital of Xiaoshan District, Hangzhou 311200, China
    3 Department of Pulmonary and Critical Care Medicine, Fujian Provincial Geriatric Hospital, Fuzhou 350003, China
    4 Department of Infectious Diseases, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China
  • Received:2022-12-07 Revised:2023-01-21 Accepted:2023-02-16 Online:2023-07-01 Published:2023-07-01
  • Contact: Jin Huang

摘要:

本文研究探讨牡蛎肽(OP)改善肝纤维化的机制可能是通过NF-κB/iNOS信号通路。将50只雄性SD大鼠采用随机数字表法随机分为5组: 对照组、模型组、低剂量(0.5 g/kg) OP组、中剂量(1.0 g/kg) OP组、高剂量(2.0 g/kg) OP组, 每组10只。皮下注射50%四氯化碳(CCl4)建立肝纤维化大鼠模型6周。结果发现, OP治疗组中, CCl4诱导的肝纤维化大鼠肝脏中I型胶原、III型胶原和TGF-β1表达水平均显著低于模型组(P < 0.05)。OP可以下调大鼠的肝组织NF-κB和iNOS的表达, 可能是通过介导NF-κB/iNOS信号通路改善大鼠肝纤维化。

关键词: 肝纤维化, 牡蛎肽, 核因子-κB, 诱导型一氧化氮合酶

Abstract:

In the present study, we found that oyster peptide (OP) could ameliorate hepatic fibrosis through the NF-κB/iNOS signaling pathway. A total of 50 male Sprague-Dawley rats were randomly divided into five groups by the random digital table method: control group, model group, low-dose (0.5 g/kg) OP group, medium-dose (1.0 g/kg) OP group, and high-dose (2.0 g/kg) OP group, with 10 rats in each group. The rat model of hepatic fibrosis was established by subcutaneous injection of 50% carbon tetrachloride (CCl4). In OP therapy groups, the expressions of collagen I, collagen III, and TGF-β1 in the liver with CCl4-induced hepatic fibrosis were significantly lower than those in the model group (P < 0.05). OP could down-regulate the expressions of NF-κB and iNOS in the liver tissue of rats with hepatic fibrosis. Collectively, OP ameliorated hepatic fibrosis, possibly through the NF-κB/iNOS signaling pathway.

Key words: Hepatic fibrosis, Oyster peptide, NF-κB, Inducible nitric oxide synthase

Supporting: