摘要：
2023年4月5日, 北京大学药学院天然药物及仿生药物国家重点实验室马明团队在JACS上发表了题为"Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis"的研究论文。该研究阐明了三种三环倍半萜环化酶的晶体结构和催化机制, 并通过环化酶的理性改造扩展倍半萜结构多样性。
Supporting:
北京大学药学院 天然药物及仿生药物国家重点实验室. 马明团队在多环倍半萜形成机制和结构多样性扩展方面取得新进展[J]. 中国药学(英文版), 2023, 32(4): 325-327.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The research team of Prof. Ming Ma has made new progress in the formation mechanism and structural diversity expansion of Polycyclic Sesquiterpenes[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(4): 325-327.
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