海藻酸钠凝胶筏的研究进展

doi:10.5246/jcps.2017.07.053

中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (7): 479-487.DOI: 10.5246/jcps.2017.07.053

海藻酸钠凝胶筏的研究进展

林亚先¹, 杨钊³, 杨楠², 蔡亚梅², 于甜甜¹, 范莹^2*

1. 青岛大学药学院药学系, 山东青岛 266021
2. 海军青岛第一疗养院, 山东青岛 266021
3. 青岛市食品药品检验研究院, 山东青岛 266021

收稿日期:2017-02-27 修回日期:2017-05-03 出版日期:2017-07-28 发布日期:2017-06-23
通讯作者: Tel.: +86-0531-51885536, E-mail: f260249100@163.com
作者简介:范莹博士, 1993年7月毕业于山东医科大学药学系, 2004年于中国海洋大学药物所获博士学位, 2009年12月任原济南军区青岛第一疗养院(现海军青岛第一疗养院)药剂科主任、药剂研究中心负责人。2013年任主任药师。主要研究方向为药物新制剂的研究与开发、海洋多糖类药物的研究与开发。

Research and development of alginate-based raft forming system

Yaxian Lin¹, Zhao Yang³, Nan Yang², Yamei Cai², Tiantian Yu¹, Ying Fan^2*

1. Department of pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China
2. Qingdao First Sanatorium of PLA NAVY, Qingdao 266021, China
3. Food and Drug Inspection Institute of Qingdao, Qingdao 266021, China

Received:2017-02-27 Revised:2017-05-03 Online:2017-07-28 Published:2017-06-23
Contact: Tel.: +86-0531-51885536, E-mail: f260249100@163.com
About author:Dr. Fan graduated from Department of Pharmaceutical Sciences, Shandong Medical University in July 1993 with the Bachelor degree. She obtained her PhD degree at School of Medicine and Pharmacy, Ocean University of China. She is the director of Pharmacy Department and the person in charge of the Pharmaceutical Research Center in Qingdao First Sanatorium of PLA Navy from Dec.2009. She became a chief pharmacist in 2013. Over these years, she has specialized in the novel drug from research and ocean polysaccharides drugs discovery and development.

摘要/Abstract

摘要：

嘉胃斯康是典型治疗胃食管返流病的海藻酸钠制剂。它在胃酸中可以形成一种漂浮的凝胶筏, 较好地阻止胃食管返流。我们评价这个体系的指标有多种参数, 如强度、体积、漂浮性、耐受力和弹性。另外, 凝胶筏的强度还受许多因素影响的比值。这两种参数是影响筏强度大小的内在因素。一些外在的因素如筏中钙离子的存在, 包裹在筏中的二氧化碳数量。本文主要总结了如何评价凝胶筏最后概括了海藻酸钠的降解情况及未来的进展。

关键词: 胃食管返流病, 海藻酸钠, 抗酸剂, 因素

Abstract:

Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease (GERD) symptoms. Alginate gel becomes buoyant and CO₂-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues (M/G), which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.

Key words: Gastroesophageal reflux disease, Sodium alginate, Antacid , formulation, Factors

中图分类号:

R975

Supporting:

林亚先, 杨钊, 杨楠, 蔡亚梅, 于甜甜, 范莹. 海藻酸钠凝胶筏的研究进展[J]. 中国药学(英文版), 2017, 26(7): 479-487.

Yaxian Lin, Zhao Yang, Nan Yang, Yamei Cai, Tiantian Yu, Ying Fan. Research and development of alginate-based raft forming system[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(7): 479-487.

参考文献

[1] Sun, J.; Yang, C.; Zhao, H.; Zheng, P.; Wilkinson, J.; Ng, B.; Yuan, Y. Aliment. Pharmacol. Ther. 2015, 42, 845-854.

[2] Beaumont, H.; Bennink, R.J.; Jong, J.D.; Boeckxstaens, G.E. Gut. 2010, 59, 441-451.

[3] Corvaglia, L.; Mariani, E.; Aceti, A.; Capretti, M.G.; Ancora, G.; Faldella, G. Neurogastroenterol Motil. 2009, 21, 1027-1081.

[4] Thomas, E.; Wade, A.; Crawford, G.; Jenner, B; Levinson, N.; Wilkinson, J. J. Aliment. Pharmacol. Ther. 2014, 39, 595-602.

[5] Clarke, A.T.; Wirz, A.A.; Seenan, J.P.; Manning, J.J.; Gillen, D.; McColl, K.E.L. Gut. 2009, 58, 904-909.

[6] Vela, M.F.; Camacho-Lobato, L.; Srinivasan, R.; Tutuian, R.; Katz P.O.; Castell, D.O. Gastroenterology. 2001, 120, 1599-1606.

[7] Fletcher, J.; Wirz, A.; Young, J.; Vallance, R.; Mccoll, K. Gastroenterology. 2001, 121, 775-783.

[8] Pandolfino, J.E.; Zhang, Q.; Ghosh, S.K.; Post, J.; Kwiatek, M.; Kahrilas, P.J. Am J. Gastroenterol. 2007, 102, 2633-2641.

[9] Lee, Y.Y.; McColl, K.E.L. Best. Pract. Res. Clin. Gastroenterol. 2013, 27, 339-351.

[10] Pouchain, D.; Bigard, M.A.; Liard, F.; Childs, M.; Decaudin, A.; McVey, D. BMC Gastroenterol. 2012, 12, 18.

[11] Rohof, W.O.; Bennink, R.J.; Boeckxstaens, G.E. Clin. Gastroenterol Hepatol. 2014, 12, 1101-1107.

[12] Dettmar, P.W.; Sykes, J.; Little, S.L.; Bryan, J. Int. J. Clin. Pract. 2006, 60, 275-283.

[13] Hampson, F.C.; Jolliffe, I.G.; Bakhtyari, A.; Taylor, G.; Sykes, J.; Johnstone, L.M.; Dettmar, P.W. Drug Dev. Ind. Pharm. 2010, 36, 614-23.

[14] Marciani, L.; Little, S.L.; Snee, J.; SColeman, N.S.; Tyler, D.J.; Sykes, J.; Jolliffe, I.G.; Dettar, P.W.; Spillerand, R.C.; Gowland, P.A. J. Pharm. Pharmacol. 2002, 54, 1351-1356.

[15] Sweis, R.; Kaufman. E.; Anggiansah. A.; Wong. T.; Dettmar, P.; Fried, M.; Schwizer, W.; Avvari, R.K.; Pal, A.; Fox, M. Aliment. Pharmacol. Ther. 2013, 37, 1093-1102.

[16] Zentilin, P.; Dulbecco, P.; Savarino, E.; Parodi, A.; Iiritano, E.; Bilardi, C.; Reglioni, S.; Vigneri, S.; Savarino, V. Aliment. Pharmacol. Ther. 2005, 21, 29-34.

[17] Rohof, W.O.; Bennink, R.J.; Smout, A.J.P.M.; Thomas, E.; Boeckxstaens, G.E. Clin. Gastroenterol Hepatol. 2013, 3, 2-10.

[18] Nayak, A.K.; Maji, R.; Das, B. J. Pharm Research. 2013, 4, 1018-1033.

[19] Buono, R.D.; Wenzl, T.G.; Ball, G.; Keady, S.; Thomson, M. Arch. Dis. Child. 2005, 90, 460-463.

[20] Lee, K.Y.; Mooney, D.J. Prog. Polym. Sci. 2012, 37, 106-126.

[21] Yang, J.; Zhao, J.; Fang, Y. Carbohydr. Res. 2008, 343, 719-725.

[22] Morris, E.R.; Rees, D.A.; Thom, D. Curb. Res. 1980, 81, 305-314.

[23] Niranjanbhai, B.D.; Mahendrakumar, V.N.; Surendran, C.S.; Upadhyay, U.M. J. Drug Deliv. Ther. 2012, 2, 123-128.

[24] Mandel, K.G.; Daggy, B.P.; Brodie, D.A.; Jacoby, H.I. Aliment. Pharmacol. Ther. 2000, 14, 669-690.

[25] Tytgat, G.N.; Simoneau, G. Aliment. Pharmacol. Ther. 2006, 23, 759-765.

[26] De, R.A.; Roman, S.; Chen, J.; Pandolfino, J.E.; Kahrilas, P.J. Aliment. Pharmacol. Ther. 2014, 40, 531-537.

[27] Hecht, H.; Srebnik, S. Biomacromolecules. 2016, 17, 2160−2167.

[28] Dettmar, P.W.; Hampson, F.C.; Taubel, J.; Lorch, U.; Johnstone, L.M.; Sykes, J.; Berry, P.J. Int. J. Clin. Pract. 2007, 61, 1654-1662.

[29] Kahrilas, P.J.; McColl, K.; Fox, M.; O’Rourke, L.; Sifrim, D.; Smout, A; BoeckxstAens, G. Am J. Gastroenterol. 2013, 108, 1058-1064.

[30] Kwiatek, M.A.; Roman, S.; Fareeduddin, A.; Pandolfino, J.E.; Kahrilas, P.J. Aliment. Pharmacol. Ther. 2011, 34, 59-66.

[31] Chater, P.I.; Wilcox, M.D.; Brownlee, I.A.; Pearson, J.P. Carbohydr. Polym. 2015, 131, 142-151.

[32] Strugala, V.; Kennington, E.J.; Campbell, R.J.; Skjak-Braek, G.; Dettmar, P.W. Int. J. Pharm. 2005, 304, 40-50.

[33] Strugala, V.; Avis, J.; Jolliffe, I.G.; Johnstone, L.M.; Dettmar, P.W. J. Pharmacol. Pharmacoth. 2009, 61, 1021-1028.

[34] Paterson, R.S.; O’Mahony, B.; Eccleston, G.M.; Stevens, H.N.E.; Foster, J.; Murray, J.G. J. Pharm. Pharmcol. 2000, 52, 8.

[35] Marciani, L.; Little, S.L.; Snee, J.; Coleman, N.S.; Tyler, D.J.; Sykes, J.; Jolliffe, I.G.; Dettmar, P.W.; Spiller, R.C.; Gowland, P.A. J. Pharm. Pharmacol. 2002, 54, 1351-1356.

[36] Duez, J.M.; Mestdagh, M.; Demeure, R.; Goudemant, J.F.; Hills, B.P.; Godward, J. Magn. Reson. Chem. 2000, 38, 324-330.

[37] Rinaudo, M. Marcel Dekker, New York. 2005, 237-252.

[38] Andriamanantoanina, H.; Rinaudo, M. PolymerInternational. 2010, 59, 1531-1541.

[39] Johnson, F.A.; Craig, D.Q.M.; Mercer, A.D.; Chauhan, S. Int. J. Pharm. 1997, 159, 35-42.

[40] Siew, C.K.; Williams, P.A.; Young, N.W. J. Biomacro-molecules. 2012, 6, 963-969.

[41] Zentilin, P.; Dulbecco, P.; Savarino, E.; Parodt, A.; Iirition, E.; Bilardi, C.; Regliont, S.; Vi-gneri, S.; Savarino, V. Aliment. Pharmacol. Ther. 2005, 21, 29-34.

[42] Pawar, S.N.; Edgar, K.J. Biomaterials. 2012, 33, 3279-3305.

[43] Tønnesen, H.H.; Karlsen, J. Drug Dev. Ind. Pharm. 2002, 28, 621-630.

[44] Farrés, I.F.; Norton, I.T. Food Hydrocolloids. 2014, 40, 76-84.

[45] Goh, C.H.; Heng, P.W.S.; Lai, W.C. Carbohydr. Polym. 2012, 88, 1-12.

[46] Donati, I.; Gamini, A.; Skjak-Braek, G.; Vetere, A.; Campa, C.; Coslovi, A.; Paoletti, S. Carbohydr. Res. 2003, 338, 1139-1142.

[47] Jonathan, M.; Silva, C.S.D.; Bosch, G.; Schols, H.; Gruppen, H. Food Chem. 2015, 172, 117-120.

[48] Washington, N.; Wilson, C.G.; Davis, S.S. Int. J. Pharm. 1985, 279-286.

[49] Xue, W.M.; Yu, W.T.; Liu, X.D.; He, X.; Wang, W.; Ma, X.J. Chem. Res. Chin. Univ. 2004, 25, 1342-1346.

[50] Fang, Y.P.; Al-Assaf, S; Phillips, G.O.; Nishinari, K.; Funami, T.; Williams, P.A.; Li, L.B. J. Phys. Chem. 2007, 111, 2456-2462.

[51] Braccini, I.; Perez, S. Biomacromolecules. 2001, 2, 1089-1096.

[52] Drury, J.L.; Dennis, R.G.; Mooney, D.J. Biomaterials. 2004, 25, 3187-3199.

[53] Draget, K.I.; Stokke, B.T. Yuguchi, Y.; Urakawa, H.; Kajiwara, K. Macromolecular Symposia. 2003, 120, 1661-1668.

[54] Crow, B.B.; Nelson, K.D. Biopolymers. 2006, 81, 419-427.

[55] Mammarella, E.J.; Rubiolo, A.C. Chem. Eng. 2003, 94, 73-77.

[56] Manabe, N.; Haruma, K.; Ito, M.; Takahashi, N.; Takasugi, H.; Wada, Y.; Nakata, H.; Katoh, T.; Miyamoto, M.; Tanaka, S. Dis. EsopHagus. 2012, 25, 373-380.

[57] Elliott, B.M.; Steckbeck, K.E.; Murray, L.R.; Erk, K.A. Int. J. Pharm. 2013, 457, 118-123.

[58] Gupta, P.; Vermani, K.; Garg, S. Drug. Discov. Today. 2002, 7, 569-579.

[59] Tian, S.; Zhou, X.Y.; Gong, H.Y.; Ma, X.M.; Zhang, F. Pharmacognosy Magazine. 2011, 7, 4-8.

[60] Vatier, J.; CeÂlice-Pingaud, C.; Farinotti, R. Int. J. Pharm. 1998, 163, 225-229.

[61] Sharma, N.; Agarwal, D.; Gupta, M.; Khinchi. Drug Invent. Today. 2010, 2, 328-330.

[62] Bhardwaj, L.; Sharma, P.K.; Malviya, R. Afr. J. Basic Appl. Sci. 2011, 3, 300-312.

[63] Washington, N.; Bell, J.S.; Lamont, G.; Wilson, C.G.; Toselli, D. STP Pharm. Sci. 1998, 8, 123-126.

[64] Chawla, G.; Gupta, P.; Koradia, P.; Bansal, V. Pharm. Technol. 2003, 27, 50-68.

[65] Prajapati, V.D.; Jani, G.K.; Khutliwala, T.A.; Zala, B.S. J. Controlled. Release. 2013, 168, 151-165.

[66] Hampson, F.C.; Farndale, A.; Strugala, V.; Sykes, J.; Jolliffe, I.G.; Dettmar, P.W. Int. J. Pharm. 2005, 294, 147-167.

[67] Kerdsakundee, N.; Mahattanadul, S.; Wiwattanapatapee, R. Eur. J. Pharm. Bio. 2015, 94, 513-520.

[68] Gulecha, B.S.; Shahi, S.; Lahoti, S.R. Am. J. PharmTech Res. 2012, 2, 954-969.

[69] Hampson, F.C.; Banks, A.; Jolliffe, I.G.; Dettmar, P.W. J. Pharm. Pharmacol. 2002, 54, S30-31.

[70] Bagul, U.S.; Patil, R.V.; Shirsath, Y.A.; Nikam, A.J.; Gujar, K.N. IJPRD. 2011, 4, 147-150.

[71] Sato, Y.; Kawashima, Y.; Takeuchi, H.; Yamamoto, H. Int. J. Pharm. 2004, 275, 75-85.

[72] Shruti, S.; Ashish, P.; Shikha, A.; Raju, C. Int. J. Pharm. Biol. Arch. 2011, 2, 1561-1568.

[73] Garg, R.; Gupta, G.D. Trop. J. Pharm. Res. 2008, 7, 1055-1066.

[74] Pandey, A.; Kumar, G.; Kothiyal, P.; Barshiliya, Y. Asian J. Pharm. Med. Sci. 2012, 2, 60-77.

[75] Arrora, S.; Ali, J.; Khar, R.K.; Baboota, S. AAPS PharmSciTech. 2005, 6, 372-390.

[76] Panwar, P.; Chourasiya, D.; Jain, G.; Sheorey, R.V. Int. J. Nov. Drug Deliv. Technol. 2012, 2, 264-270.

[77] Hoebler, C.; Guillon, F.; Darcy-Vrillon, B.; Vaugelade, P.; Lahaye, M.; Worthington, E.; Due´e, P.H.; Barry, J.L. J. Sci. Food Agric. 2000, 80, 1357-1364.

[78] Deville, C.; Gharbi, M.; Dandrifosse, G.; Peulen, O. J. Sci. Food Agric. 2007, 87, 1717-1725.

[79] Zheng, H.H. Carbohydr. Res. 1997, 302, 97-101.

[80] Boontheekul, T.; Kong, H.J.; Mooney, D.J. Biomaterials. 2005, 26, 2455-2465.

[81] Miwa, H.; Sasaki, M.; Furuta, T.; Koike, T.; Habu, Y.; Ito, M.; Fujiwara, Y.; Wada, T.; Nagaara, A.; Hongo, M.; Kinoshita, Y. Aliment. Pharmacol. Ther. 2007, 26, 69-77.

[82] Hoad, C.L.; Rayment, P.; Spiller, R.C.; Marciani, L.; Peters H.P.; Gowland P.A. J. Nutr. 2004, 134, 2293.

[83] Norton, I.T.; Frith, W.J.; Ablett, S. Food Hydrocolloids. 2006, 20, 229-239.

[84] Tester, R.; Hooper, D. Patent. 2007, WO104905.

[85] Beely, M.; Warner, J.O. Curr. Med. Res. Opin. 1972, 1, 63-69.

[86] Fass, R.; Sifrim, D. Gut. 2009, 58, 295-309.

[87] Singh, B.N.; Kim, K.H. J. Controlled. Release. 2000, 63, 235-259.

海藻酸钠凝胶筏的研究进展

Research and development of alginate-based raft forming system

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	王可欣, 田胜男, 王佳, 靳瑾, 王婷婷, 张丽藏, 刘焕龙. 基于KAP理论的石家庄市区居民用药风险调查研究[J]. 中国药学(英文版), 2023, 32(9): 755-763.
[2]	刘文夏, 马俊, 杨照, 江滨. 中国仿制药替代影响因素分析——基于"4 + 7"带量采购精神科用药患者角度[J]. 中国药学(英文版), 2023, 32(4): 317-321.
[3]	邹鑫峰, 郭海华, 邓樑钧, 杨淯婷, 袁正强, 谭文. 基于综合因素刺激的肠易激综合征模型构建方法学研究[J]. 中国药学(英文版), 2023, 32(3): 180-189.
[4]	彭词艳, 陈景, 李斯妮, 李健和, 彭六保. 后疫情时代中南地区脑卒中患者经济负担及影响因素研究[J]. 中国药学(英文版), 2022, 31(7): 545-555.
[5]	余恒毅, 方一念, 王开付, 陈倩, 杜艾桦, 任秀华, 刘东. 生物等效性试验中健康受试者的脱落原因及主动脱落相关因素分析[J]. 中国药学(英文版), 2021, 30(9): 754-761.
[6]	李佳乐, 杨艳, 黄兆耆, 莫小兰. 结合雌激素治疗幼女阴唇粘连的效果评价及影响因素分析[J]. 中国药学(英文版), 2021, 30(12): 976-985.
[7]	王壮飞, 管晓东, 周越, 韩晟, 姚鹏, 史录文. 中国中老年人自我药疗发生率及影响因素研究：基于CHARLS 2011年, 2013年和2015年的面板数据[J]. 中国药学(英文版), 2019, 28(6): 430-438.
[8]	林向红, 胡豪, 刘伊, 管晓东, 宋佳芳, 史录文. 中国制药企业研发国际化的影响因素综合研究[J]. 中国药学(英文版), 2018, 27(3): 209-214.
[9]	刘疆燕, 李秀男, 张晓雪, 黄豪雁, 陈利清, 崔京浩, 曹青日. 改善双氯芬酸钾颗粒及胶囊剂稳定性的工艺优化研究[J]. 中国药学(英文版), 2018, 27(2): 82-91.
[10]	管晓东, 马莉莉, 王国英, 海沙尔江·吾守尔, 满春霞, 韩晟, 史录文. 中国2型糖尿病患者胰岛素注射笔用针头重复使用的影响因素研究[J]. 中国药学(英文版), 2018, 27(1): 51-58.
[11]	施亮, 王增, 俞婷婷, 夏亮. 慢性病及其治疗药物可能会影响肺癌患者术后5年生存率[J]. 中国药学(英文版), 2017, 26(2): 147-155.
[12]	侯甜甜, 王岩青, 田蕊, 张光鹏. 县级公立医院医生薪酬现状及其影响因素研究[J]. 中国药学(英文版), 2015, 24(7): 482-486.
[13]	王增, 蔡鑫君, 刘孟娟, 卢红阳, 林能明. 年龄、性别及2型糖尿病对于胃癌发生的风险: 一项单一机构的回顾性分析[J]. 中国药学(英文版), 2014, 23(11): 799-803.
[14]	奚宝晨, 丁庆明, 史录文^* . 口服降糖药罗格列酮在临床应用中的危险因素分析 [J]. , 2008, 17(4): 332-336.
[15]	潘妍^*, 李英剑, 赵会英, 郝劲松, 郑俊民. 胰岛素壳聚糖纳米粒的制备及影响包封率因素的考察[J]. , 2002, 11(3): 97-100.