旱莲草化学成分旱莲甙A和旱莲甙B的分离和鉴定

旱莲草化学成分旱莲甙A和旱莲甙B的分离和鉴定

张梅^*, 陈雅妍

北京医科大学药学院, 北京 100083

收稿日期:1996-06-17 修回日期:1996-09-27 出版日期:1996-12-15 发布日期:1996-12-15
通讯作者: 张梅*

Isolation and Identification of Ecliptasaponin A andEcliptasaponin B from Eclipta alba (L.) Hassk

Mei Zhang^*, Ya-Yan Chen

College of Pharmaceutical sciences, Beijing Medical University, Beijing 100083

Received:1996-06-17 Revised:1996-09-27 Online:1996-12-15 Published:1996-12-15
Contact: Mei Zhang*

摘要/Abstract

摘要： 自旱莲草全草(Ecliptaa lba (L.) Hassk)中分得4个三萜化合物, 经理化常数测定和光谱(IR, MS, UV, ¹H NMR, ¹³C NMR和¹³C-¹H COSY)解析, 2个已知的三萜化合物分别为刺囊酸(echinocysticacid, 1)和齐墩果酸(oleanolicacid, 2), 另2个为新化合物, 分别命名为旱莲甙A(ecliptasaponinA, 3)和旱莲甙B(ecliptasaponinB, 4)。I和II为首次从鳢肠属植物中获得。

关键词: 旱莲草, 三萜皂甙, 旱莲甙A, 旱莲甙B

Abstract: Two new triterpenoid glucosides ecliptasaponin A (3) and ecliptasaponin B (4) were isolated together with echinocystic acid (1) and oleanolic acid (2) from Eclipta alba (L.) Hassk.Their structures were deduced as 3β,16α-dihydroxy olean-12-ene-28-oic acid-3β-O-β-D-glu-copyranoside (3) and 3β-O-[β-D-glucopyranosyl(1-4)]-β-D-glucopyranosyl-16α-hydroxy olean-12-ene-28-oic acid 28-O-β-D-glucopyranoside(4), based on spectral analysis and chemical evidences as well as results ofhydrolysis.

Key words: Eclipta alba (L.) Hassk, Triterpenoid glucoside, Ecliptasaponin A, Ecliptasaponin B

Supporting: First published in Chinese in Acta Pharmaceutica Sinica 1996; 31(3): 196-199.
Present address: Department of Pharmaceutics, General Hospital, Beijing Military Command, Beijing 100700.

张梅^*, 陈雅妍. 旱莲草化学成分旱莲甙A和旱莲甙B的分离和鉴定[J]. .

Mei Zhang^*, Ya-Yan Chen. Isolation and Identification of Ecliptasaponin A andEcliptasaponin B from Eclipta alba (L.) Hassk[J]. .

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