中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (9): 762-772.DOI: 10.5246/jcps.2021.09.064
覃思蓓1,2, 贾彤2, 扶宇2, 李俊蕾2, 张欣怡2, 祝春素2, 梁广楷2, 聂小燕2,*(), 史录文2, 崔一民1,2,*()
收稿日期:
2021-01-21
修回日期:
2021-03-15
接受日期:
2021-03-24
出版日期:
2021-09-27
发布日期:
2021-09-27
通讯作者:
聂小燕, 崔一民
作者简介:
基金资助:
Sibei Qin1,2, Tong Jia2, Yu Fu2, Junlei Li2, Xinyi Zhang2, Chunsu Zhu2, Guangkai Liang2, Xiaoyan Nie2,*(), Luwen Shi2, Yimin Cui1,2,*()
Received:
2021-01-21
Revised:
2021-03-15
Accepted:
2021-03-24
Online:
2021-09-27
Published:
2021-09-27
Contact:
Xiaoyan Nie, Yimin Cui
摘要:
氯吡格雷是目前使用最广泛的P2Y12受体抑制剂之一。CYP3A4在氯吡格雷肝脏代谢中起重要作用。因此,CYP3A4基因多态性或许对服用氯吡格雷治疗的心脑血管疾病患者预测氯吡格雷疗效起重要作用。本研究对CYP3A4基因多态性对心脑血管疾病患者氯吡格雷响应的影响进行meta分析。对2019年10月7日之前发表在Pubmed、Embase、Cochrane Library、clinicaltrail.gov、中国知网(CNKI)、万方数据库上的文献进行系统性检索, 纳入评价CYP3A4不同突变型患者的血小板反应性与临床结局的队列研究或病例对照研究。使用Review Manager软件进行数据分析, 使用NOS量表评价纳入文献的质量。总共纳入18篇文献进行Meta分析。Meta分析结果显示,CYP3A4基因多态性对心脑血管疾病患者服用氯吡格雷后的血小板反应性无显著影响。同时,CYP3A4基因多态性对心脑血管疾病患者长期服用氯吡格雷后的结局无显著影响。
Supporting:
覃思蓓, 贾彤, 扶宇, 李俊蕾, 张欣怡, 祝春素, 梁广楷, 聂小燕, 史录文, 崔一民. CYP3A4基因多态性对心脑血管疾病患者氯吡格雷响应影响的Meta分析[J]. 中国药学(英文版), 2021, 30(9): 762-772.
Sibei Qin, Tong Jia, Yu Fu, Junlei Li, Xinyi Zhang, Chunsu Zhu, Guangkai Liang, Xiaoyan Nie, Luwen Shi, Yimin Cui. Association between CYP3A4 gene polymorphisms and clopidogrel response in patients with cardio-cerebrovascular diseases: a systematic review and Meta-analysis[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(9): 762-772.
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