紫红獐牙菜𠮿酮提取物对MPTP所致的帕金森小鼠的神经保护作用

doi:10.5246/jcps.2016.05.040

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (5): 357-365.DOI: 10.5246/jcps.2016.05.040

紫红獐牙菜𠮿酮提取物对MPTP所致的帕金森小鼠的神经保护作用

郭涌斐, 王辰, 李婉, 张珂, 雷慧, 孙懿, 蒲小平^*, 赵欣^*

北京大学医学部药学院分子与细胞药理学系; 天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2016-02-24 修回日期:2016-03-14 出版日期:2016-05-30 发布日期:2016-03-29
通讯作者: Tel.: +86-010-82802431, +86-010-82802648, E-mail: pxp2020@126.com, zhaoxin2010@bjmu.edu.cn
基金资助:
National key foundation for exploring scientific instrument of China (Grant No. 2013YQ030651), National Natural Science Foundation of China (Grant No. 81202937).

Neuroprotective effects of xanthone extract from Swertia punicea Hemsl against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease

Yongfei Guo, Chen Wang, Wan Li, Ke Zhang, Hui Lei, Yi Sun, Xiaoping Pu^*, Xin Zhao^*

Department of Molecular and Cellular Pharmacology; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2016-02-24 Revised:2016-03-14 Online:2016-05-30 Published:2016-03-29
Contact: Tel.: +86-010-82802431, +86-010-82802648, E-mail: pxp2020@126.com, zhaoxin2010@bjmu.edu.cn
Supported by:
National key foundation for exploring scientific instrument of China (Grant No. 2013YQ030651), National Natural Science Foundation of China (Grant No. 81202937).

摘要/Abstract

摘要：

紫红獐牙菜提取物是一种应用广泛的中国传统中药, 其抗乙型肝炎病毒, 保肝, 降低血糖等作用已经被报道。在本研究中, 我们发现紫红獐牙菜𠮿酮提取物可以改善1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森(PD)小鼠的运动功能障碍。此外, 我们还发现该提取物能够提高纹状体中多巴胺(DA)和高香草酸(HVA)的含量, 缓解由于MPTP导致的黑质致密区的酪氨酸羟化酶(TH)阳性神经元的缺失。这些结果表明, 紫红獐牙菜𠮿酮提取物具有对抗MPTP神经毒素的神经保护作用, 有望成为一个潜在的治疗帕金森病的药物。

关键词: 紫红獐牙菜??酮提取物, 帕金森病, 1-甲基-4-苯基-1,2,3,6-四氢吡啶, 多巴胺, 高香草酸, 酪氨酸羟化酶

Abstract:

As a widely used traditional Chinese medicine (TCM), Swertia punicea Hemsl has exhibited effects on anti-hepatitis B virus (HBV), liver protection, hypoglycemic activity and cholecystitis. In this study, we confirmed that xanthone extract from Swertia punicea Hemsl (XSPH) improved the motor deficit, increased the levels of striatal dopamine (DA) and homovanilic acid (HVA), and alleviated the loss of tyrosine hydroxylase (TH)-positive neurons located in substantia nigra pars compacta (SNpc) in MPTP-induced mouse model of Parkinson’s disease (PD). In conclusion, the present results indicated that XSPH offered neuroprotective effects against the neurotoxicity of MPTP and it might be a potential treatment for PD.

Key words: Xanthone extract from Swertia punicea Hemsl, Parkinson’s disease, MPTP, Dopamine, Homovanilic acid, Tyrosine hydroxylase

中图分类号:

R961

Supporting:

郭涌斐, 王辰, 李婉, 张珂, 雷慧, 孙懿, 蒲小平, 赵欣. 紫红獐牙菜𠮿酮提取物对MPTP所致的帕金森小鼠的神经保护作用[J]. 中国药学(英文版), 2016, 25(5): 357-365.

Yongfei Guo, Chen Wang, Wan Li, Ke Zhang, Hui Lei, Yi Sun, Xiaoping Pu, Xin Zhao. Neuroprotective effects of xanthone extract from Swertia punicea Hemsl against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(5): 357-365.

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紫红獐牙菜𠮿酮提取物对MPTP所致的帕金森小鼠的神经保护作用

Neuroprotective effects of xanthone extract from Swertia punicea Hemsl against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease

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