关键词: 硫氧还蛋白还原酶, 乳腺癌, 生物标志物, 治疗监控, 药物靶点

Abstract:

Overexpression of thioredoxin reductase has been identified in a variety of primary tumors, suggesting the levels of TrxR activity between tumor patients and normal people are potentially different. Here, we performed a study to investigate the differences of TrxR activity between normal people and breast tumor patients, with the expectation that TrxR activity can be considered as a novel biomarker involved in breast cancer diagnosis and treatment. In this study, we have demonstrated for the first time that TrxR levels in breast cancer patients before therapy were significantly higher than those of normal people (P<0.05). No significant difference of TrxR activity was found among the patients at different stages of breast tumor progression. In the patient group of TrxR <10 U/mL, evaluation of TrxR activity has shown a high consistency with the results from cancer diagnostic imaging. Overall, these observations suggest TrxR as an effective biomarker to monitor and evaluate the clinical outcome of breast cancer therapeutics, and identify TrxR activity as a novel approach for breast cancer early-stage detection.

Key words: Thioredoxin reductase, Breast cancer, Biomarker, Diagnostic monitor, Drug target