一叶萩生物碱的合成和生物活性

doi:10.5246/jcps.2011.03.026

一叶萩生物碱的合成和生物活性

张文, 李军勇, 蓝平, 孙平华, 王英, 叶文才, 陈卫民^*

暨南大学药学院, 中药药效物质基础及创新药物研究广东省高校重点实验室, 广东广州 510632

收稿日期:2011-01-05 修回日期:2011-03-20 出版日期:2011-05-06 发布日期:2011-05-06
通讯作者: 陈卫民*

Chemical synthesis and biological activities of Securinega alkaloids

Wen Zhang, Jun-Yong Li, Ping Lan, Ping-Hua Sun, Ying Wang, Wen-Cai Ye, Wei-Min Chen^*

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China

Received:2011-01-05 Revised:2011-03-20 Online:2011-05-06 Published:2011-05-06
Contact: Wei-Min Chen*

摘要/Abstract

摘要：

一叶萩生物碱是从大戟科植物一叶萩, 叶下珠属以及白饭树属中提取的一类化合物。它们中大部分呈现出广泛的生物活性, 例如GABA受体拮抗活性, 抗疟和抗菌活性。由于它的结构的特殊性, 合成不同骨架的一叶萩生物碱对于有机化学和药物化学家来说是具有挑战性的工作。在本文中我们对几种一叶萩碱的全合成以及生物活性进行了概述。

关键词: 一叶萩生物碱, 合成, 生物活性

Abstract:

The Securinega alkaloids are a group of compounds isolated from the plants of Securinega, Phyllanthus and Flueggea genera belonging to the Euphorbiaceae family. Most of these compounds exhibit a wide range of biological activities, such as GABA receptor antagonist, antimalarial and antibacterial activity. Due to the special structural features of Securinega alkaloids, the synthesis strategies for their different structural skeletons are challenging for organic and medicinal chemists. In the review, we will provide an overview of the total synthesis of several Securinega alkaloids and their biological activities.

Key words: Securinega alkaloids, Synthesis, Biological activities

中图分类号:

R916.2

Supporting:

Foundation items: Joint Fund of NSFC-Guangdong Province (Grant No. U0932004) and National Natural Science Foundation of China (Grant No. 20902038).
^*Corresponding author. Tel.: 86-20-85224497

张文, 李军勇, 蓝平, 孙平华, 王英, 叶文才, 陈卫民^*. 一叶萩生物碱的合成和生物活性[J]. , DOI: 10.5246/jcps.2011.03.026.

Wen Zhang, Jun-Yong Li, Ping Lan, Ping-Hua Sun, Ying Wang, Wen-Cai Ye, Wei-Min Chen^*. Chemical synthesis and biological activities of Securinega alkaloids[J]. , DOI: 10.5246/jcps.2011.03.026.

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