Table of Content

15 September 1997, Volume 6 Issue 3

Previous Issue    Next Issue

Full Papers

Diterpenoids from the Roots of Agastache rugosa

Zhong-Mei Zou, De-Quan Yu, Pu-Zhu Cong

1997, 6(3):  115-118. 

Asbtract ( 958 )   PDF (357KB) ( 594 )  

References | Related Articles | Metrics

Agastol (2), a new diterpene, was isolated from the roots of Agastache rugosa together with its isomer, named isoagastol (3). Their structures were established on the basis of spectral methods The structures of agastol (2) and isoagastol (3) was elucidated as 11,14-dihydroxy-12-methoxy-19(4→3) abeo-abieta-4(18),8,11,13-tetraen-7-one and 11,14-dihydroxy-12-methoxy-19(4→3) abeo-abieta-3,8,11,13-tetraen-7-one. Isoagastol was isolated for the first time from natural sources.

Desmosflavanone II: A New Flavanone from Desmos cochinchinensis Lour

Jiu-Hong Wu, Shi-Xuan Liao, Shi-Long Mao, Hua-Qing Liang, Yan-Lai Wang, Zhong Wu Su

1997, 6(3):  119-121. 

Asbtract ( 1142 )   PDF (286KB) ( 699 )  

References | Related Articles | Metrics

A new flavanone was isolated from the roots of Desmos cochinchinensis Lour Its chemical structure was elucidated by spectral analysis as 7-hydroxy-5-methoxy-8-formyl-6-methylflavanone, named desmosflavanone II.

Five Isoflavonoid Compounds from the Roots of Caragana sinica

Li-Ping Zhang, Mei-Hua Ju, Chang-Qi Hu^*

1997, 6(3):  122-124. 

Asbtract ( 1039 )   PDF (294KB) ( 660 )  

References | Related Articles | Metrics

The roots of Caragana sinica (Buc'hoz) Rehd is a Chinese folk medicine used for the treatment of asthenia syndrome, vascular hypertension, leukorrhagia, arthrodynia, and as antiinflammatory agent From the ethanolic extract of the roots of C-sinica, five isoflavonoid compounds were isolated and identified as flemichapparin B, formononetin, pseudobaptigenin, 5-hydroxy-7,4'-dimethoxy isoflavone and 5-hydroxy-7-methoxy-3',4'-methylenedioxy isoflavone.

Chemical Constituents of Stellera chamaejasme

Gui-Fang Liu^*, Jin Wang, Yu-Qin Fu, Song-Song Yang

1997, 6(3):  125-128. 

Asbtract ( 1176 )   PDF (299KB) ( 631 )  

References | Related Articles | Metrics

Twelve compounds 1~12 were obtained from the root of Stellera chamaejasme L. Five (2,3,5,7,8) of them have been elucidated by spectroscopic and physico-chemical measurements as umbelliferone (2), β-sitosterol (3), daucosterol (5), daphnoretin (7) and 7-methoxydaphnoretin (8). Compound 8 is a new compound named isodaphnoretin. Compound 2, 5 and 8 were isolated for the first time from this plant.

Chemical Constituents of Illicium difengpi Bark

Ping Huang, Min Yang, Mao-Xiang Lai, Xue-Zhong Zheng, Masatoshi Nishi, Tsutomu Nakanishi

1997, 6(3):  129-132. 

Asbtract ( 1346 )   PDF (353KB) ( 633 )  

References | Related Articles | Metrics

Three compouds were isolated from the traditional Chiese medicine "difengpi", which is the bark of Illicium difengpi K. I. B et K. I. M. They were identified as difengpin (1), magnolol (2) and B-sitosterol (3) by physico-chemical constants and spectral analsis (UV, IR, NMR, EIMS). Compound 1 is a new compound having the stucture of 4-allyi-2,6-dimethoxy-phenol cinnamate and named difengpin.

Synthesis of 3-Nitrogen containing Function Substituted Lanosterol Derivatives-Inhibitors of (S)-Adenosyl-L-Me-thionine: Δ²⁴⁽²⁵⁾-Sterol Methyltransferase

De-An Guo, Jun Hu, Jun-Hua Zheng, Samir A.Ross, W.David Nes

1997, 6(3):  133-137. 

Asbtract ( 910 )   PDF (306KB) ( 552 )  

References | Related Articles | Metrics

Syntheses of 3-ketolanosterol, 3-acetolanosterol, 3-oximolanosterol, 3α- and 3β-aminolanosterol were described The products have been fully characterized on the basis of their chromatographic (TLC Rf, GLC RRTc) and spectral (IR, MS, ¹H NMR, ¹³C NMR) properties.

Synthesis and Antiinflammatory Activity of 2-(4-Methoxy benzylidene)-5-aminomethyl Cyclopentanone Derivatives

Ying Kang, Yu-Lan Li, Ying Xu, Zhi-Zhong Ji

1997, 6(3):  138-142. 

Asbtract ( 323 )   PDF (358KB) ( 493 )  

References | Related Articles | Metrics

In this paper, ten new derivatives of 2-(4-methoxybenzylidene)-5-aminomethyl cyclopentanone were designed and synthesized. The structures of all these ten title compounds have been confirmed by IR, ¹H NMR and elemental analysis. The compounds have been examined for the anti-inflammatory activity on carrageenin-induced rat paw edema test. Through chemical synthesis, we have confirmed that the amino exchange reaction proceeds by an elimination-addition mechanism.

Protective Effect of Tetrandrine against Excitatory Amino Acids induced Neuronal Injury in Cortical Culture

Jian-Tu Che, Jun-Tian Zhang, Fei-Song Chen, Zhi-Wei Qu

1997, 6(3):  143-148. 

Asbtract ( 261 )   PDF (1343KB) ( 530 )  

References | Related Articles | Metrics

The ability of tetrandrine (Tet), an alkaloid isolated from Radix Stephaniae Tetrandrae, to reduce cortical neuronal injury in cortical cultures derived from fetal rats was quantitatively assessed by examination of morphological changes and measurement of lactate dehydrogenase (LDH) released to the extracellular bathing media. Cell cultures exposed to the excitatory amino acids (EAA)-50 μmol·L^-1 glutamate (Glu), 20 μmol·L^-1 N-methyl-D-aspartate (NMDA), 300 μmol·L^-1 β-N-oxalylamino-L-alanine (BMAA, NMDA receptor agonist) or 20 μmol·L^-1 β-N-oxaly-lamino-L-alanine (BOAA, non-NMDA receptor agonist)for 24 h at 37 ºC showed widespread neuronal injury. Tet had little effect on the injury induced by 20 μmol·L^-1 NMDA but 10^-7 and 10^-6 μmol·L^-1 Tet did partially attenuate the neuronal degeneration, neuronal loss and LDH efflux resulting from prolonged exposures to 100 μmol·L^-1 Glu, 300 μmol·L^-1 BMAA and 20 μmol·L^-1 BOAA respectively. The ability of Tet to reduce the neuronal injury induced by prolonged exposure to EAA may contribute, at least in part, to the reduction of Ca²⁺ influx through inhibiting the opening of voltagegated Ca²⁺ channels. Another mechanism that Tet might have a little inhibitory effect on NMDA receptor on neuronal membrane cannot be excluded, as BMAA has been considered to act as a weak NMDA receptor agonist.

A New Method of Receptor Mapping to Predict Bioactivity

Hong-Ming Chen, Tian-Rui Ren, Jia-Ju Zhou

1997, 6(3):  149-153. 

Asbtract ( 833 )   PDF (361KB) ( 432 )  

References | Related Articles | Metrics

We used genetic algorithm to construct pseudoreceptor site models and made use of the high correlation between interaction energy, which was between the models and the ligands, and bioactivity data of known molecules to predict the bioactivity of unknown molecules. For the system of ALS enzyme inhibitor, this emthod can give reasonable predictions of the bioactivity of ALS enzyme inhibitor.

Studies on Quantitative Determination of Active Principies in Chinese Herbal Medicine by Second DerivativeDifferential Pulse Polarography

Yun-Ai Liang

1997, 6(3):  154-159. 

Asbtract ( 1915 )   PDF (312KB) ( 431 )  

References | Related Articles | Metrics

The second derivative differential pulse polarography was developed for the quantitative determination ofactive principles in medicinal herbs(baicalin in Scutellaria baicalensis Georgi, indigo in Baphicacanthus cusia(Nees) Bremek, paeonol in Paeonia suffruticosa Andr.and piperine in Piper longum L.). The group in baicalin, indigo, paeonol and piperine could be reduced to in acidic solution at the dropping mercury electrode, and showed very good second derivative differential pulse polarographic peak at -1.550 V, -1.300 V, -1.630 V and -0.860 V (Vs Ag/AgCl) respectively. The linear relationship between concentration of baicalin, indigo, paeonol, piperine and peak height was obtained in the concentration range of 4.5×10^-5~2.7×10^-4 mol·L^-1, 3.8×10^-5~2.5×10^-4 mol·L^-1, 1.0~6.0×10^-4 mol·L^-1 and 7.0×10^-5~2.5×10^-4 mol·L^-1 and the determination limits were 9.0×10^-8 mol·L^-1, 8.4×10^-9 mol·L^-1, 9.2×10^-9 mol·L^-1 and 8.7×10^-9 mol·L^-1 respectively.fhis method is simple, rapid and sensitive, and the results are accurate.

Temperature Effects on Seed Dormancy Relieving of Frit-illaria thunbergii Miq.

Wen-Yuan Gao, Zhi-Liang Li, Pei-Gen Xiao

1997, 6(3):  160-164. 

Asbtract ( 1308 )   PDF (372KB) ( 455 )  

References | Related Articles | Metrics

The seed dormancy relieving of Fritillaria thunbergii Miq. required 50 days at 8~10 ºC and 80 days at 3~5 ºC. In order to study the physiological basis for seed dormancy relieving. peroxidase, acid phosphatase and proteins were assayed by spectrophotometric analysis and electrophoresis. The results showed that peroxidase activity and acid phosphatase activity increased and new bands were detected in protein patterns as the seeds were treated with low temperature, these changes resulted in the seed dormancy relieving.

Communications

The Chemical Constituents from the Roots of Bupleurum chinense

Qing-Cui Li, Hong Liang, Yu-Ying Zhao, Ru-Yi Zhang, Li-He Zhang

1997, 6(3):  165-167. 

Asbtract ( 1575 )   PDF (288KB) ( 532 )  

References | Related Articles | Metrics

Two New Oleanolic Acid Saponins from the Root Bark of Aralia taibaiensis

Hai-Feng Tang, Zhong-Zhuang Wang, Yang-Hua Yi, Ya-Xuan Fan, Wen-Jun Hu, Yi-Qing Li

1997, 6(3):  168-171. 

Asbtract ( 1151 )   PDF (354KB) ( 445 )  

References | Related Articles | Metrics