Abstract: In this paper, ten new derivatives of 2-(4-methoxybenzylidene)-5-aminomethyl cyclopentanone were designed and synthesized. The structures of all these ten title compounds have been confirmed by IR, ¹H NMR and elemental analysis. The compounds have been examined for the anti-inflammatory activity on carrageenin-induced rat paw edema test. Through chemical synthesis, we have confirmed that the amino exchange reaction proceeds by an elimination-addition mechanism.

Key words: Cyclopentanones, Antiinflammatory activity, Amino-exchange reaction