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Synthesis of 3-Nitrogen containing Function Substituted Lanosterol Derivatives-Inhibitors of (S)-Adenosyl-L-Me-thionine: Δ24(25)-Sterol Methyltransferase

De-An Guo, Jun Hu, Jun-Hua Zheng, Samir A.Ross, W.David Nes   

  1. 1. School of Pharmaceutical Sciences; Beijing Medical University; Beijing 100083;
    2. Department of Chemistry and Biochemistry; Texas Tech University; Lubbock 79409; USA
  • Received:1996-12-26 Revised:1997-05-15 Online:1997-09-15 Published:1997-09-15

Abstract: Syntheses of 3-ketolanosterol, 3-acetolanosterol, 3-oximolanosterol, 3α- and 3β-aminolanosterol were described The products have been fully characterized on the basis of their chromatographic (TLC Rf, GLC RRTc) and spectral (IR, MS, 1H NMR, 13C NMR) properties.

Key words: Biosynthesis, Inhibitor, Lanosterol, Sterol methyltransferase, Synthesis

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