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Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (10): 673-686.DOI: 10.5246/jcps.2019.10.064

• Reviews •     Next Articles

Anticancer activity of Isoliquiritigenin: biological effects and molecular mechanisms

Wenxiu Xin*, Qilu Fang, Jiao Sun, Sisi Kong, Lingya Chen, Ping Huang*   

  1. Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Received:2019-04-16 Revised:2019-06-18 Online:2019-10-31 Published:2019-07-21
  • Contact: Tel.: +86-571-88122438; +86-571-88122118, E-mail: xinwx@zjcc.org.cn; huangping1841@zjcc.org.cn
  • About author:Dr. Wenxiu Xin graduated from Shandong Normal University in 2009 with a major in pharmaceutical engineering. She was admitted to College of Pharmaceutical Sciences in Zhejiang University in 2009 and received his PhD degree in pharmacology in 2014. Since 2014, she has worked in the pharmacy department of Zhejiang Cancer Hospital, successively as pharmacist (2014) and chief pharmacist (2016). Over these years, she has specialized in the research of anti-tumor pharmacodynamics research of traditional Chinese medicine. She has published 16 associated papers in domestic and international journals as the first author or correspondent author, including 5 SCI papers, and presided over one National Natural Science Foundation of China as well as one Zhejiang Natural Science Foundation.
  • Supported by:

    Chinese Medicine Research Program of Zhejiang Province (Grant No. 2016ZA035), Projects of Medical and Health Technology Program in Zhejiang Province (Grant No. 2016KYA053), Zhejiang Provincial Association of Integrative Medicine Research Fund Project (Grant No. 2016LYK020).

Abstract:

Natural compounds derived from plants have attracted considerable attention in the scientific community due to their nontoxic nature and anti-cancer activity. Isoliquiritigenin (ISL), an active flavonoid isolated from the root of the licorice plant (Glycyrrhiza uralensis), has been previously demonstrated to have anti-inflammatory, antioxidant and tumor suppressive effects. In the past few years, the number of studies describing the effects of ISL against cancer has been gradually increased. ISL has been found to inhibit viability, proliferation, and migration of cancer cells mainly through cell cycle arrest, induction of apoptosis as well as autophagy. However, the molecular mechanisms of action are not completely comprehended. This review aimed to provide a comprehensive summary of the biological effects and molecular mechanisms of ISL against cancer.

Key words: Cancer, Isoliquiritigenin, Effect, Mechanism

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