An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

doi:10.5246/jcps.2023.08.050

Abstract

Abstract:

In this overview, the current knowledge of the constituents of flavonoids isolated from the roots of Sophora flavescens (kushen) is updated. Flavonoids consist of several classes, such as flavanones, flavonols, chalcones, isoflavones, biflavonoids, flavanols, and flavones. The most common compounds are kurarinone (KRN), sophoraflavanone G (SFG), 2?-methoxykurarinone, kuraridine, isoxanthohumol, and formononetin. KRN and SFG are two major flavanones with more vital anticancer properties than other flavonoids. From the literature, the cytotoxic values of KRN and SFG are variable and depend on the type of cancer cells tested. The anticancer activities of these two flavonoids involve different molecular mechanisms. Clinical trials are needed before anticancer drugs from KRN and SFG can be developed.

Key words: Kushen, Flavanones, Cytotoxicity, Molecular mechanisms

Supporting:

Eric Wei Chiang Chan, Ying Ki Ng, Hung Tuck Chan, Siu Kuin Wong. An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(8): 603-615.

Figures/Tables 5

References 88

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