The effects of midazolam combined with dezocine on laparoscopic appendectomy

doi:10.5246/jcps.2023.03.018

Abstract

Abstract:

In the present study, we aimed to investigate the effect of midazolam combined with dezocine on anesthesia induction before laparoscopic appendectomy. A total of 107 patients with appendicitis in our hospital from June 2018 to March 2021 were randomly divided into the control group (53 cases) and the observation group (54 cases). The control group was given midazolam, and the observation group was given midazolam combined with dezocine. The vitals, analgesia, sedation indexes, and adverse reactions of the two groups were compared. Compared with time T0, HR and MAP at T1, T2, T3, and T4 in both groups were decreased (P < 0.05), while there was no significant change in T1–T4 in the two groups, respectively (P > 0.05). MAP of the observation group was lower than that of the control group at the T1–T4 time points (P < 0.05). SPO₂ showed no significant change at all time points (P > 0.05). The NRS score at 6 h after surgery of the observation group (3.52 ± 1.28 scores) was significantly lower compared with the control group (4.26 ± 1.76 scores, P < 0.05). The Ramsay sedation score at 1 h after surgery of the observation group (2.32 ± 0.78 scores) was significantly higher compared with the control group (1.73 ± 0.65 scores, P < 0.05). Moreover, there was no significant difference in the incidence of adverse reactions between the observation group (7.4%) and the control group (11.3%, P > 0.05). Collectively, midazolam combined with dezocine could better reduce postoperative MAP and postoperative pain in patients with laparoscopic appendectomy, showing good postoperative sedation effect and safety.

Key words: Laparoscopic appendicitis, Midazolam, Dezocine, Effect, Safety

Supporting:

Changping Lin, Sanyue Wang, Yunguo Xue, Youliu Yu. The effects of midazolam combined with dezocine on laparoscopic appendectomy[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(3): 207-213.

Figures/Tables 3

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