Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2

doi:10.5246/jcps.2013.01.002

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Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2

Chunhua Lu, Lin Zhao, Yuezhong Li, Yuemao Shen^*

1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
2. Shandong Provincial Key Laboratory of Microbial Engineering, Shandong Institute of Light Industry, Jinan 250353, China
3. State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Jinan 250010, China

Received:2012-09-19 Revised:2012-11-22 Online:2013-01-20 Published:2013-01-20
Contact: Yuemao Shen*

Abstract

Abstract:

Four natural epothilone analogues, including two 14-membered epothilones L (1), L1 (2) and two epoxide opened epothilones A (3) and B (4), were isolated from the extract of fermentation adsorber resin of Sorangium cellulosum strain So0157-2. Their structures were elucidated on the basis of comprehensive NMR and MS data. They are all isolated from the wild type S. cellulosum strain So0157-2 as natural products for the first time.

Key words: 14-Membered epothilones, Epoxide opened epothilone, Sorangium cellulosum strain So0157-2

CLC Number:

R284

Supporting:

Chunhua Lu, Lin Zhao, Yuezhong Li, Yuemao Shen^* . Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2[J]. , DOI: 10.5246/jcps.2013.01.002.

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Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2

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