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Chemical constituents from the leaves of Premna microphylla Turcz

Zhengxi Hu, Yongbo Xue, Guangmin Yao, Zengwei Luo, Yanyan Wang*, Yonghui Zhang*   

  1. 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    2. First College of Clinical Medical Science of China, Three Gorges University & Yichang Central People's Hospital, Yichang 443003, China
  • Received:2013-02-28 Revised:2013-03-25 Online:2013-09-15 Published:2013-09-15
  • Contact: Yanyan Wang*, Yonghui Zhang*

Abstract:

Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin (1), blumenol A (2), (3S,5R,6S,7E,9R)-5,6-epoxy-3,9-dihydroxy-7-megastigmene (3), 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one (4), ixerol B (5), (-)-dehydrovomifoliol (6), 3S,5R-dihydroxy-6S,7-megastigmadien-9-one (7), loliotide (8), (+)-dehydrololiolide (9), (+)-medioresinol (10), 4-oxopinoresinol (11), tormentic acid (12), and indole-3-carboxylic acid (13). Compounds 213 described above were isolated from this genus for the first time.

Key words: Verbenaceae, Premna, Premna microphylla Turcz, Chemical constituents, Structural identification

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