A new alkaloid from Chaetomium globosum

doi:10.5246/jcps.2018.09.063

Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (9): 617-622.DOI: 10.5246/jcps.2018.09.063

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A new alkaloid from Chaetomium globosum

Chuanjun Huang^1,2, Xiaorui Liu³, Mi Zhang³, Qiong Bie³, Fanrong Zeng³, Yanyan Wang⁴, Chunmei Chen³, Hucheng Zhu^3*, Yonghui Zhang^3*

1. Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
2. Hubei Research Institute of Traditional Chinese Medicine, Wuhan 430074, China
3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
4. First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, China

Received:2018-04-15 Revised:2018-05-18 Online:2018-09-29 Published:2018-06-30
Contact: Tel.: +86-27-83692892, E-mail: zhangyh@mails.tjmu.edu.cn; zhuhuceng@hust.edu.cn
Supported by:
National Natural Science Foundation of China (Grant No. 31570361).

Abstract

Abstract:

A new alkaloid, methyl 6-(isoprenyl)-1H-indole-3-carboxylate (1), was isolated from the solid culture broth of fungus Chaetomium globosum, together with five known compounds, including N-acetyl-L-tryptophan (2), xylariol B (3), 5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde (4), ergosterol (5) and ergosta-4,6,8(14),22-tetraen-3-one (6). Their chemical structures were elucidated by spectroscopic data (UV, IR, HRESIMS, and NMR). In addition, it is the first report of compounds 2 and 3 from the fungus Chaetomium globosum.

Key words: Chaetomium globosum, Chemical constituents, Alkaloid

CLC Number:

R284

Supporting:

Chuanjun Huang, Xiaorui Liu, Mi Zhang, Qiong Bie, Fanrong Zeng, Yanyan Wang, Chunmei Chen, Hucheng Zhu, Yonghui Zhang. A new alkaloid from Chaetomium globosum[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(9): 617-622.

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A new alkaloid from Chaetomium globosum

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