Chemical constituents from agarwood of Aquilaria filaria

doi:10.5246/jcps.2021.06.039

Abstract

Abstract:

Investigations on the chemical constituents from the ethanol extract of the agarwood originating from Aquilaria filaria led to the isolation of 26 compounds by column chromatography, including silica gel, Sephadex LH-20, and semi-preparative high-performance liquid chromatography. Their structures were determined to be β-sitostenone (1), 24α-ethyl-cholestan-3α-ol (2), ergosta-4,6,8(14), 22-tetraene-3-one (3), gypsogenin (4), hederagenin (5), 17αH-trisnorhopanone (6), lupeol (7), friedelin (8), (?)-episyringaresinol (9), (?)-syringaresinol (10), 5-hydroxy-7,4′-dimethoxyflavone (11), 5,4'-dihydroxy-7,3′-dimethoxyflavone (12), 2′-hydroxy-4,3′,6′,4′′-tetramethoxy-p-terphenyl (13), scopularide A (14), 4-(4-hydroxyphenyl)butan-2-one (15), zingerone (16), coniferaldehyde (17), scopoletin (18), acetovanillon (19), isovanillin (20), vanillin (21), p-hydroxybenzaldehyde (22), p-hydroxybenzoic acid (23), protocatechuic acid (24), vanillic acid (25) and 4,5-dihydroxy-3-methoxybenzoic acid (26) by using spectroscopic techniques. All compounds were isolated from agarwood of A. filaria for the first time, and this was also the first report about the isolation of compounds 2, 4, 6, 7, 9, 10, 13?15, 17?20, 22, 24 and 26 from agarwood and Aquilaria plants.

Key words: Agarwood of Aquilaria filaria, Chemical constituents, Triterpene, Steroid

Supporting:

Chengneng Mi, Wenli Mei, Jingzhe Yuan, Wenxing Long, Haofu Dai. Chemical constituents from agarwood of Aquilaria filaria[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 505-517.

Figures/Tables 1

References 48

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