A new 3, 11-cyclotaxane diterpenoid from Taxus media Rehd. cv. Hicksii

doi:10.5246/jcps.2013.01.003

Abstract

Abstract:

The aim of current study was to investigate the chemical constituents of the needles of Taxus media. The isolation and purification of components were achieved by a series of chromatography including silica gel, Sephadex LH-20, MCI and reversed-phase HPLC. Their structures were indentified based on 1D, 2D NMR, and mass spectral analysis. Seven taxane diterpenoids were isolated and identified as 1β,2α,9α,10β-tetrahydroxy-5α-cinnamoyloxy-3,11-cyclotaxa-4(20)-en-13-one (1), 2α, 7β, 9α, 10β, 13α-pentaacetoxytaxa-4(20), 11-dien-5α-ol (2), 2-deacetoxy-5-decinnamoyltaxinine J (3), taxuspine F (4), taxuspinanane K (5), taxchin A (6), and baccatin IV (7). Among them, 1 is a new compound and compounds 2, 5, 6 and 7 are isolated from Taxus media for the first time.

Key words: Taxus media, Taxane diterpenoid, Chemical constituents, Structural identification

CLC Number:

R284.2

Supporting:

Rong Yang, Kehui Xie, Tianzhi Cai, Hongzheng Fu^*. A new 3, 11-cyclotaxane diterpenoid from Taxus media Rehd. cv. Hicksii [J]. , DOI: 10.5246/jcps.2013.01.003.

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A new 3, 11-cyclotaxane diterpenoid from Taxus media Rehd. cv. Hicksii

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