Optimization for supercritical CO2 extraction of icariin by response surface method

doi:10.5246/jcps.2011.02.020

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Optimization for supercritical CO₂ extraction of icariin by response surface method

Ya-Qiong Guan, Yao-Wu Zhang^*, Long Zhang

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received:2010-12-03 Revised:2011-02-10 Online:2011-03-15 Published:2011-03-15
Contact: Yao-Wu Zhang*

Abstract

Abstract:

The aim of the present study was to optimize the supercritical CO2 extraction conditions of icariin from Herba Epimedii by response surface method (RSM) and central composite design (CCD). A 3-factor, 5-level CCD was used for the optimization. Independent variables were extraction temperature, extraction pressure and entrainer flow rate. Dependent variable was yield ratio of icariin from Herba Epimedii. A two-order polynomial equation was fitted to the data. The results showed that the optimum extraction conditions were as follows: extraction temperature 46.5 ºC, extraction pressure 30.6 MPa, entrainer flow rate 3.3 mL/min. CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.

Key words: Response surface method, Central composite design, Supercritical fluid extraction, Herba Epimedii, Icariin

CLC Number:

R284

Supporting:

Ya-Qiong Guan, Yao-Wu Zhang^*, Long Zhang . Optimization for supercritical CO₂ extraction of icariin by response surface method [J]. , DOI: 10.5246/jcps.2011.02.020.

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Optimization for supercritical CO₂ extraction of icariin by response surface method

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