Anti-complement constituents of Commelina communis and their targets in complement activation cascade

doi:10.5246/jcps.2012.06.073

Abstract

Abstract:

Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis. Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH₅₀values of 0.12-1.44 mM and AP₅₀ values of 0.28-7.05 mM, respectively. Preliminary mechanism studies demonstrated that quinovic acid acted on C1q, C2, C3, C4, C5 and C9 components of the complement system, β-sitosterol interacted with C3 and C4, (+)-catechin-3-O-β-D-gluco(2-cinnamoyl)-pyranoside, p-cresol and 6-methoxy-3-methylbenzene-1,2,4-triol blocked C1q, C2, C3, C5 and C9.

Key words: Commelina communis, Chemical constituents, Complement inhibitor, Action targets

CLC Number:

R962.1

Supporting:

Jiahong Jin, Zhihong Cheng, Daofeng Chen^*. Anti-complement constituents of Commelina communis and their targets in complement activation cascade[J]. , DOI: 10.5246/jcps.2012.06.073.

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Anti-complement constituents of Commelina communis and their targets in complement activation cascade

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