Lignans and flavonoids from Artemisia brachyloba

doi:10.5246/jcps.2018.06.043

Journal of Chinese Pharmaceutical Sciences

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Lignans and flavonoids from Artemisia brachyloba

Puming Zhang, Chen Zhang, Kewu Zeng, Yong Jiang^*, Pengfei Tu^*

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2018-05-05 Revised:2018-05-15 Online:2018-06-30 Published:2018-06-01
Contact: Tel.: +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
Supported by:
National Natural Science Foundation of China (Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

Abstract

Abstract:

A phytochemical investigation on the aerial parts of Artemisia brachyloba led to the isolation of 13 compounds (1−13) for the first time, including eight lignans (1−8) and five flavonoids (9−13). The structures of the isolated compounds were elucidated by analysis of the NMR spectroscopic data and comparison with the literature.The ¹H and ¹³C NMR data of 1 were fully assigned for the first time by the 2D NMR analysis. All the isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-challenged BV-2 microglial cells.

Key words: Artemisia brachyloba, Lignans, Flavonoids, NO

CLC Number:

R284

Supporting:

Puming Zhang, Chen Zhang, Kewu Zeng, Yong Jiang, Pengfei Tu. Lignans and flavonoids from Artemisia brachyloba[J]. Journal of Chinese Pharmaceutical Sciences, DOI: 10.5246/jcps.2018.06.043.

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Lignans and flavonoids from Artemisia brachyloba

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