Two novel phorbol esters from Croton tiglium L.

doi:10.5246/jcps.2016.10.086

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (10): 771-778.DOI: 10.5246/jcps.2016.10.086

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Two novel phorbol esters from Croton tiglium L.

Wentong Dou^1,2, Yanping Hao¹, Junli Liu², Dan Yuan^1*, Hongzheng Fu^2*

1. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China

Received:2016-05-16 Revised:2016-05-30 Online:2016-10-27 Published:2016-06-02
Contact: Tel.: +86-010-82805212, E-mail: drhzfu@sina.com
Supported by:
National Natural Science Foundation of China (Grant No. 81172943).

Abstract

Abstract:

To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. (family Euphorbiaceae), its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were identified based on 1D, 2D NMR and mass spectral analysis. A total of 10 phorbol esters were obtained. Among them, compound 1 (12-O-(2-methyl)butyryl-4α-deoxyphorbol-13-isobutyrate) and compound 10 (20-formyl-4α-deoxyphorbol-13-acetate) were two new compounds, and the other eight were known compounds.

Key words: Croton tiglium L., Chemical constituents, Phorbol esters

CLC Number:

R284

Supporting:

Wentong Dou, Yanping Hao, Junli Liu, Dan Yuan, Hongzheng Fu. Two novel phorbol esters from Croton tiglium L.[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(10): 771-778.

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Two novel phorbol esters from Croton tiglium L.

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