Analgesic components of Dahurian Angelica root in the serum of a rat model

doi:10.5246/jcps.2015.09.080

Abstract

Abstract:

In the present study, we aimed to determine the major components responsible for the analgesic effects of Dahurian Angelica root. The rats were administered with either the volatile oil or decoction of Dahurian Angelica root. Formalin plantar injection test was employed as the pain model. The rats were observed for nociception, after which their blood was collected fromthe abdominal aorta. High-performance liquid chromatography (HPLC) fingerprints of serum were performed. The results demonstrated that no remarkable analgesic effect was observed from the low-dose decoction group, whereas the other doses showed pain-relieving effects in the rat model. The components of the rat sera in the different treatments were determined by HPLC. Common chromatographicpeaks were observed at 24.941, 25.755, 29.854, 32.761 and 33.928 min, representing the major constituents of the decoction and volatile oil of Dahurian Angelica root. The analgesic components of Dahurian Angelica root obtained from the rat serum mainly peaked at 24.941, 25.755, 29.854, 32.761 and 33.928 min, suggesting trace components and metabolites.

Key words: Volatile oil, Decoction, Serum, HPLC chromatogram

CLC Number:

R917

Supporting:

Cite this article

Qiubing Cui, Yaohui You, Bi Wang. Analgesic components of Dahurian Angelica root in the serum of a rat model[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(9): 630-634.

share this article

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: http://jcps.bjmu.edu.cn/EN/10.5246/jcps.2015.09.080

http://jcps.bjmu.edu.cn/EN/Y2015/V24/I9/630

References

[1] Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Part 1. Beijing: China Medical Sciences and Technology Press. 2010, 97.

[2] Liu, R.; Li, A.; Sun, A. J. Chromatogr. A. 2004, 1052, 217-221.

[3] Mammen, J.S.; Kleiner, H.E. J. Pharmacogene. Genom. 2005, 15, 183-188.

[4] Deng, R.; Zhang, J.; Luo, W.Z. Chin. Mater. Med. 2010, 35, 3184-3187.

[5] Zhang, C.Y.; Li, Z.G.; Wang, Q.X. Chin. Med. Mater. 2007, 30, 1374-1378.

[6] Yuan, Y.Z.; Ni, Y.N.J. Anal. Sci. 2009, 25, 26-30.

[7] Wang, X.J. Chin. Mater. Med. 2006, 31, 789-792.

[8] Wei, Y.F.; Zhang, N.; Feng, Y. Chin. Tradit. Herb. Drugs. 2009, 40, 1489-1492.

[9] Nei, H.; Zhang, H.; Zhang, X.Q. Nat. Prod. Res. 2011, 25, 53-61.

[10] Peng, X.L.; Gao, X.L.; Chen, J.C. Integr. Tradit. Western Med. 2004, 24, 243-247.

[11] Cui, Q.B.; Zhang, Y.; Wang, N. Chin. Tradit. Patent Med. 2011, 33, 1260-1262.

[12] Wang, T.T.; Chen, X.H.; Hu, Q.Q.; Bi, K.S. . Pharm. Sin2006, 41, 747-751.

[13] Zimmermann, M. Pain. 1983, 16,109-110.

[14] Nie, H.; Shen, Y.J. Chin. Mater. Med. 2002, 27, 690-693.

[15] Wang, D.; Yang, H.; Tong, L. Pharm. Clin. Res. 2008, 16, 90-93.

[16] Zhu, S.J.; Hu, R.; Jia, Y.R. Chin. Clin. Rehabilitation. 2004, 8, 1518-1519.

[17] Lin, X.M.; Huang, W.; Wei, X.C. Chin. Clin. Rehabilitation. 2004, 8, 272-273.

[18] Chen, R.M.; Jiao, M.; Yin, S.M . W. J. Integr. Tradit. Western Med. 2008, 3, 454-456.

[19] Zhang, C.M.; Wang, G.Z.; Cao, H. J. Chin. Clin. Reha-bilitation. 2006, 10, 82-84.

[20] Deng, C.; Wu, Y.; Meng, X.L. Pharm. Clin. Chin. Mater. Med. 2008, 24, 31-33.

[21] Cao, Y.; Zhu, D.N.; Lin, Z.H. J. Chin. Pharm. Univ. 2007, 38, 519-522.

[22] Liao, Z.G.; Liang, X.L.; Zhu, J.Y. J. Ethnopharmacol. 2010, 129,115-120.

Related Articles 15

[1]	Gedi Zhang, Gengxin Liu, Ziyou Yan. Therapeutic efficacy evaluation and mechanism of action based on meta-analysis and network pharmacology of Li Chong Decoction (Bolus) for cancer treatment [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(9): 720-735.
[2]	Dongyan Wu, Xiaodan Wang, Jinmiao Chai, Qinqing Li, Yue Li, Mei Bi, Wanwei Gui, Huimin Cao. Study on the mechanism of Danggui Buxue decoction in the treatment of diabetic retinopathy based on network pharmacology and experiment [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(7): 527-538.
[3]	Huan Yan, Jian Wang, Hao Fu, Min Yang, Miao Qu, Zhie Fang. Discussion on the potential target and mechanism of Dachaihu Decoction in treating hyperlipidemia based on network pharmacology [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(6): 446-459.
[4]	Mengya Wang, Kuanyou Zhang, Xin Chen, Hao Fu, Shouchun Peng. Study on the mechanism of Rhinoceros Horn and Rehmannia Decoction in the treatment of systemic lupus erythematosus based on the method of network pharmacology [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(5): 351-359.
[5]	Lei Lu, Chengying Qiu, Qian Chen. Effect of Lianhua Qingwen granule combined with cefotaxime sodium on the efficacy and serum inflammatory factors in children with pediatric pneumonia [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(11): 947-953.
[6]	Ning Ding, Tao Zhang, Ji Luo, Haochen Liu, Yu Deng, Yongheng He. Study on the mechanism of Baishao Qiwu Decoction in the treatment of colorectal cancer based on network pharmacology and molecular docking [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(1): 17-31.
[7]	Feng Zhao, Rui Wang, Hongxiong Zhang, Taixiang Gao, Nan Wang. Pharmacodynamics of Yuebi Jiazhu Decoction on renal protection of adriamycin nephropathy rats [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(9): 711-717.
[8]	Gong Fang, Wenxi Li, Jie Zhang, Qinghua Ke, Xinggui Zhu, Lihua Long, Changhai Li. Safety and tolerability of available drugs for hyperuricemia: a critical review and an update on recent developments [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(6): 397-411.
[9]	Yinglin Yang, Shanshan Zhang, Man Liu, Dongni Liu, Yuehua Wang, Guanhua Du. Network pharmacological analysis of Xiao-Xu-Ming decoction against ischemic stroke and verification of its mechanism of anti-inflammation and neurovascular protection in vivo [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(5): 343-359.
[10]	Taixiang Gao, Feng Zhao, Liyao Shi, Rui Wang. Exploring the mechanism of Fu-Zi Decoction in treatment of chronic heart failure based on network pharmacology and molecular docking technology [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(9): 705-715.
[11]	Yinglin Yang, Shanshan Zhang, Man Liu, Yuehua Wang, Guanhua Du. Xiao-Xu-Ming decoction extract ameliorates brain injury in rats with thrombotic focal ischemic stroke and understanding possible therapeutic targets using proteomics [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 468-483.
[12]	Xiaomei Xu, Lisha Li, Yamin Zhang, Xuehua Lu, Rongqing Xu, Shuangshuang Wu, Wei Lin, Wenjin Lin. Hypolipidemic effects of Alismatis Rhizoma decoction on the lipid profile in hyperlipidemia rats by RNA-sequencing [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(5): 409-420.
[13]	Qian Chen, Xuyang Zhao, Yujing Song, Shaoyi Li, Wanyu Lei, Weining Ma, Zhuo Huang. Identification of serum biomarkers for evaluating seizure outcome after resective epilepsy surgery [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(8): 528-541.
[14]	Xiao Cheng, Huan Yang, Yinglin Yang, Weihan Li, Man Liu, Yuehua Wang, Guanhua Du. Xiao-Xu-Ming decoction extract alleviates LPS-induced neuroinflammation associated with down-regulating TLR4/MyD88 signaling pathway in vitro and in vivo [J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(2): 88-99.
[15]	Nan Zhang, Yiwen Gao, Chanmei Lv, Xiaoli Yang, Guihua Yue. Effect of Huanglian Jiedu Decoction on vascular endothelium factor and expression of RhoA protein factor in young spontaneously hypertensive rats [J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(2): 114-120.

Metrics

Viewed

Full text

Abstract

Comments

Abstract
References
Related Articles
Recommended Articles
Metrics
Comments

TOP