Pharmacodynamics of Yuebi Jiazhu Decoction on renal protection of adriamycin nephropathy rats

doi:10.5246/jcps.2022.09.060

Abstract

Abstract:

In the present study, we aimed to investigate the protective effect of Yuebi Jiazhu Decoction (YBJZD) on the kidney of adriamycin nephropathy (AN) rats. Rats were injected with adriamycin for modeling, except for the control group. After the successful establishment of the animal model, rats were randomly divided into the model group, YBJZD low-, medium-, and high-dose groups, and the positive group. The 24-h urine samples were collected. Biochemical indicators were monitored, and kidney tissues were collected for pathological analysis using light microscopy. The results showed that through 4 weeks of drug intervention, the urinary protein level was lower in the YBJZD and positive groups compared with the model group (P < 0.05). Serum levels of BUN, SCr, and TG were significantly lower (P < 0.01), and ALB was significantly higher (P < 0.01) in the YBJZD and positive groups compared with the model group. Compared with the model group, the pathological injury of kidney tissue in the YBJZD and positive groups was significantly alleviated. These outcomes proved that YBJZD had a renal protective effect on AN rats.

Key words: Yuebi Jiazhu Decoction, Adriamycin nephropathy rats, Nephrotic?syndrome, Pharmacodynamics

Supporting:

Feng Zhao, Rui Wang, Hongxiong Zhang, Taixiang Gao, Nan Wang. Pharmacodynamics of Yuebi Jiazhu Decoction on renal protection of adriamycin nephropathy rats[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(9): 711-717.

Figures/Tables 4

References 28

[1]	Hu, F.Y.; Xie, M.Y. Effect of low molecular weight heparin calcium combined with prednisone in children with primary nephrotic syndrome. Med. Innov. China. 2019, 16, 17–20.
[2]	Li, F.X.; Hou, Y.L.; Zhou, L.S.; Dong, Y.; Zhao, J.W.; Li, Z.X. The status and model of children primary nephrotic syndrome in continuing nursing. Ann. Palliat. Med. 2021, 10, 2398–2407.
[3]	Hao, S.; Wu, Y.; Kang, Y.L.; Niu, X.; Zhu, G.; Huang, W.Y. A single-center analysis of primary nephrotic syndrome with acute pancreatitis in children. Med. (Baltimore). 2020, 27, e21056.
[4]	Cao, J.; Li, J.; Shen, H. Study on the clinical effect of benazepril combined with prednisone in treatment of pediatric patients with nephrotic syndrome. J. Clin. Exp. Med. 2019, 18, 2543–2546.
[5]	He, Y.; Zhao, X.Y. Effect of low molecular heparin combined with prednisone on the treatment of nephrotic syndrome and its influence on renal function, APTT and PT levels in children. J. North Sichuan Med. Coll. 2018, 33, 268–270.
[6]	Liu, X.R.; Mu, Y.; Liu, H.M.; Deng, C. Diagnostic value of plasma protein Z and factor VIII in primary nephrotic syndrome. Clin. study. 2019, 05, 135–136.
[7]	Yan, S.P.; Zhuang, X.L.; Ai, S.; Qiu, C.X.; Zheng, J. Discussion on the treatment of primary nephrotic syndrome from "Kai Guimen, Jiejing Fu and Quwan Chencuo". Lishizhen Med. Mater. Med. Res. 2021, 04, 931–932.
[8]	Wei, H.M.; Xiang, S.W.; Liu, W.L.; Zhong, W.L. Research Progress of Jingfang in Treating Renal Edema. Mass. Technol. 2020, 07, 83–86.
[9]	Zhang, Z.J. Synopsis of Golden Chamber. Beijing: China Medical Science Press. 2018, 45–47.
[10]	Fu, H.L. Clinical Observation of Using Yuebi Jiazhu Decoction Combined with Wuling Powder in Treating Adult Primary Nephrotic Syndrome of Wind with Water Syndrome. Sichuan Tradit. Chin. Med. 2020, 02, 125–128.
[11]	Jia, P.P.; Song, D.; Song, C.D.; Chen, Y.; Hua, S.T. The Effects of Zhenwu Decoction and Yuebi Jiazhu Decoction on the Expression of B7-1 in Renal Tissue of Model Rats with Adriamycin Nephropathy. J. Tradit. Chin. Med. 2019, 05, 989–993.
[12]	Huang, Y.F.; Wei, L.B. Ten Methods of Treating Kidney in Jin Gui Yao Lue. Chin. J. Nephrol. Integr. Tradit. West. Med. 2015, 12, 1106–1108.
[13]	Xu, K. M. S. thesis, Changchun University of Traditional Chinese Medicine. 2019.
[14]	Zhang, N.; Gao, Y.W.; LV, C.M.; Yang, X.L.; Yue, G.H. Effect of Huanglian Jiedu Decoction on vascular endothelium factor and expression of RhoA protein factor in young spontaneously hypertensive rats. J. Chin. Pharm. Sci. 2019, 28, 114–120.
[15]	Noone, D.G.; Iijima, K.; Parekh, R. Idiopathic nephrotic syndrome in children. Lancet. 2018, 392, 61–74.
[16]	Lee, V.W.; Harris, D.C. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology. 2011, 16, 30–38.
[17]	Li, A.P.; Zhang, W.N.; Qin, X.M. Optimization of adriamycin-induced nephropathy rat model. Chin. Tradit. Herb. Drugs. 2018, 49, 151–159.
[18]	Chang, J. Effect of Guizhi Fuling Decoction combined with Prednisone Tables on Inflammatory Factors in Children with Primary Nephrotic Syndrome. Bright Tradit. Chin. Med. 2021, 13, 2236–2238.
[19]	Yu, Q. Clinical observation on the treatment of IgA nephropathy with nephrotic syndrome by integrated traditional Chinese and western medicine. China Heal. Stand. Manag. 2017, 8, 107–108.
[20]	Wen, D.F. Significance of Traditional Chinese Medicine Intervention for Primary Nephrotic Syndrome During Hormone Withdrawal Period. World Latest Med. Inf. 2019, 99, 304–305.
[21]	Tian, M.M. HUANG huang’s Clinical Experience of Yuebi Jiazhu Decoction. J. Jiangxi Univ. Tradit. Chin. Med. 2021, 06, 17–21.
[22]	Miao, S.M.; Zhang, Q.; Bi, X.B.; Cui, J.L.; Wang, M.L. A review of the phytochemistry and pharmacological activities of Ephedra herb. Chin. J. Nat. Med. 2020, 18, 321–344.
[23]	Zhao, F.; Gao, T.X.; Shi, L.Y.; Wang, R. Establishment of HPLC Fingerprints, Content Determination and Chemical Pattern Recognition Analysis of Yuebi Jiazhu Decoction. China Pharm. 2021, 32, 2724–2730.
[24]	Liu, N.; Wang, Y.Q.; Du, F.; Bian, X.H.; Sun, G.P.; Zhang, B.R.; Zhou, G.Y. Adriamycin induced a nephropathy model of focal segmental glomerulosclerosis in mice. Pract. Pharm. Clin. Remedies. 2014, 17, 1536–1540.
[25]	Soyoral, Y.; Aslan, M.; Emre, H.; Begenik, H.; Erdur, F.M.; Turkel, A.; Selek, S.; Erkoc, R. Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome. Atheroscler. 2011, 01, 243–246.
[26]	Tang, G.Y.; Wen, H.; Wang, J.J.; Zhang, H.J.; Liu, Y. Evaluation research of adriamycin-induced nephropathy model in rats. Drug Eval. Study. 2020, 01, 66–71.
[27]	Colucci, M.; Corpetti, G.; Emma, F.; Vivarelli, M. Immunology of idiopathic nephrotic syndrome. Pediatr. Nephrol. 2018, 33, 573–584.
[28]	Lama, G.; Luongo, I.; Tirino, G.; Borriello, A.; Carangio, C.; Salsano, M.E. T-lymphocyte populations and cytokines in childhood nephrotic syndrome. Am. J. Kidney Dis. 2002, 39, 958–965.