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Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (9): 711-717.DOI: 10.5246/jcps.2022.09.060

• Original articles • Previous Articles     Next Articles

Pharmacodynamics of Yuebi Jiazhu Decoction on renal protection of adriamycin nephropathy rats

Feng Zhao#, Rui Wang#,*(), Hongxiong Zhang, Taixiang Gao, Nan Wang   

  1. School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China
  • Received:2022-05-10 Revised:2022-06-11 Accepted:2022-06-20 Online:2022-09-30 Published:2022-09-30
  • Contact: Rui Wang
  • About author:
    # Feng Zhao and Rui Wang contributed equally to this work.

Abstract:

In the present study, we aimed to investigate the protective effect of Yuebi Jiazhu Decoction (YBJZD) on the kidney of adriamycin nephropathy (AN) rats. Rats were injected with adriamycin for modeling, except for the control group. After the successful establishment of the animal model, rats were randomly divided into the model group, YBJZD low-, medium-, and high-dose groups, and the positive group. The 24-h urine samples were collected. Biochemical indicators were monitored, and kidney tissues were collected for pathological analysis using light microscopy. The results showed that through 4 weeks of drug intervention, the urinary protein level was lower in the YBJZD and positive groups compared with the model group (P < 0.05). Serum levels of BUN, SCr, and TG were significantly lower (P < 0.01), and ALB was significantly higher (P < 0.01) in the YBJZD and positive groups compared with the model group. Compared with the model group, the pathological injury of kidney tissue in the YBJZD and positive groups was significantly alleviated. These outcomes proved that YBJZD had a renal protective effect on AN rats.

Key words: Yuebi Jiazhu Decoction, Adriamycin nephropathy rats, Nephrotic?syndrome, Pharmacodynamics

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