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柔红霉素隐形脂质体的药剂学性质

张华, 齐宪荣, 张强*   

  1. 北京大学药学院药剂教研室, 北京 100083;
  • 收稿日期:2001-08-01 修回日期:2001-10-24 出版日期:2001-12-15 发布日期:2001-12-15
  • 通讯作者: 张强*

Pharmaceutical Characteristics of Daunorubicin Stealth Liposomes

Zhang Hua, Qi Xianrong, Zhang Qiang*   

  1. Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083
  • Received:2001-08-01 Revised:2001-10-24 Online:2001-12-15 Published:2001-12-15
  • Contact: Zhang Qiang*

摘要: 本文研究了柔红霉素隐形脂质体的药剂学性质。考察了柔红霉素隐形脂质体的形态和粒径分布; 考察了柔红霉素隐形脂质体的包封率和脂质体在Hepes缓冲液(pH 7.5)和大鼠血清中的体外释放行为。结果表明所制备的柔红霉素隐形脂质体包封率高(>85%),平均粒径为56.3 nm,体外释放慢。结论认为制备的隐形脂质体包封率较高,药剂学性质较好,适于临床使用。

关键词: 隐形脂质体, 柔红霉素, 包封率, 体外释放

Abstract: This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were examined. Visible spectrophotometry and the HPLC method were established for determination of the DNR in the DNRSL. The release of DNR from DNRSL in HBS (pH 7.5) and rat serum at 37 °C were examined. The results showed that the DNRSL had high entrapment efficiency (>85%), small size and slow release.

Key words: Stealth liposomes, Stealth liposomes, Daunorubicin, Daunorubicin, Entrapment efficiency, Entrapment efficiency, Drug release in vitro, Drug release in vitro

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