柔性脂质体的促渗作用研究

柔性脂质体的促渗作用研究

胡新, 刘艳, 吕继华, 崔小锋

北京大学药学院药剂系, 北京 100083

收稿日期:2001-11-12 修回日期:2001-12-20 出版日期:2002-03-15 发布日期:2002-03-15

Promoting Effect of the Ultradeformable Liposomes on Transdermal Delivery

Hu Xin, Liu Yan, Lu Jihua, Cui Xiaofeng

School of Pharmaceutical Science, Beijing University, Beijing 100083

Received:2001-11-12 Revised:2001-12-20 Online:2002-03-15 Published:2002-03-15

摘要/Abstract

摘要： 本文以水扬酸钠为模型药,系统研究了不同柔性脂质体的经皮促渗能力,实验结果表明掺有强亲水性表面活性剂的脂质体具有很好的促渗作用,是一类新的透皮促进剂。

关键词: 柔性脂质体, 表面活性剂, 水杨酸钠

Abstract: In this article different types of ultradeformable liposomes were designed and the properties of transdermal delivery were studied with sodium salicylate as model drug. These results showed that liposomes with strong hydrophilic surfactant added is a new type of penetration enhancer.

Key words: Ultradeformable liposomes, Ultradeformable liposomes, Surfactants, Surfactants, Sodium salicylate, Sodium salicylate

Supporting:

胡新, 刘艳, 吕继华, 崔小锋. 柔性脂质体的促渗作用研究[J]. .

Hu Xin, Liu Yan, Lu Jihua, Cui Xiaofeng .

Promoting Effect of the Ultradeformable Liposomes on Transdermal Delivery

[J]. .

[1]	杨绪朋, 仰浈臻, 张泸, 孙琪, 齐宪荣. 采用无表面活性剂体系合成不同形貌金纳米星[J]. 中国药学(英文版), 2019, 28(9): 641-649.
[2]	邱玉琴, 李爽, 李芳, 张锁慧, 高云华^*. 表面活性剂-醇质体增强多烯紫杉醇经皮给药的渗透性研究[J]. , 2011, 20(5): 466-472.