四苯硼钠法测定乳酸环丙沙星的含量

四苯硼钠法测定乳酸环丙沙星的含量

赵彦生, 李彦威^*, 魏文珑, 王晋辉

1.太原理工大学化学工程与技术学院, 太原 030024;
2.山西大学校医院, 太原 030006

收稿日期:2001-08-26 修回日期:2002-01-26 出版日期:2002-03-15 发布日期:2002-03-15
通讯作者: 李彦威*

Determination of Ciprofloxacin Lactate by Sodium Tetraphenylboron Method

Zhao Yansheng, Li Yanwei^*, Wei Wenlong, Wang Jinhui

1. College of Chemical Engineering and Technology, Taiyuan University of Technology, Taiyuan 030024;
2. Hospital of Shanxi University, Taiyuan 030006

Received:2001-08-26 Revised:2002-01-26 Online:2002-03-15 Published:2002-03-15
Contact: Li Yanwei*

摘要/Abstract

摘要： 本文介绍一种测定乳酸环丙沙星含量的有效方法。在pH = 4.0的HAc-NaAc缓冲溶液中, 乳酸环丙沙星可与四苯硼钠定量地形成分子比为1:1的沉淀, 待沉淀反应完全后, 过滤, 弃去初滤液。以溴酚蓝为指示剂, 用十六烷基三甲基溴化铵标准溶液滴定续滤液中过量的四苯硼钠, 方法简便快速, 应用于多批乳酸环丙沙星原料药样品的测定, 其回收率为99.66%-100.2%, 相对误差<±0.40 %, 与中国药典法测得的结果基本一致.

关键词: 乳酸环丙沙星, 四苯硼钠, 溴酚蓝, 十六烷基三甲基溴化铵

Abstract: This paper describes an effective method for determining ciprofloxacin lactate. An excess of sodium tetraphenylboron was added to precipitate ciprofloxacin lactate in HAc-NaAc buffer solution (pH = 4.0). After filtering off the precipitate, the excessive sodium tetraphenylboron in the filtrate was titrated with cetyltrimethylammonium bromide standard solution, with bromophenol blue as indicator. The method is simple and rapid, it has been applied to the determination of ciprofloxacin lactate raw material with satisfactory results. The recovery was between 99.66% and 100.2%, the relative error was less than ±0.40%. Experiments showed that the method gave the same results as the approach using nonaqueous titration (ChP).

Key words: Ciprofloxacin lactate, Ciprofloxacin lactate, Sodium tetraphenylboron, Sodium tetraphenylboron, Bromophenol blue, Bromophenol blue, Cetyltrimethylammonium bromide, Cetyltrimethylammonium bromide

Supporting:

赵彦生, 李彦威^*, 魏文珑, 王晋辉. 四苯硼钠法测定乳酸环丙沙星的含量[J]. .

Zhao Yansheng, Li Yanwei^*, Wei Wenlong, Wang Jinhui . Determination of Ciprofloxacin Lactate by Sodium Tetraphenylboron Method[J]. .