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巴豆属植物 Croton hemiargyerius var.gymnodiscus 中生物碱的研究

林文翰*, 付宏征, 李军, 程刚, Roderick A.Barnes   

  1. 1.北京大学天然药物及仿生药物国家重点实验室, 100083 北京;
    2.里约联邦大学天然产物研究中心, 里约热内卢 21941 巴西
  • 收稿日期:2003-03-25 修回日期:2003-08-10 出版日期:2003-09-15 发布日期:2003-09-15
  • 通讯作者: 林文翰*

The Alkaloids from Leaves of Croton hemiargyerius var. gymnodiscus

LIN Wen-han*, FU Hong-zheng, LI Jun, CHENG Gang, Roderick A.Barnes   

  1. 1.State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China;
    2.Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saude, Federal University of Rio de Janeiro, Rio de Janeiro 21941, Brasil
  • Received:2003-03-25 Revised:2003-08-10 Online:2003-09-15 Published:2003-09-15
  • Contact: LIN Wen-han*

摘要: 目的 从巴西巴豆属药用植物的一新变种复制Muel的叶中分离生物碱成分。方法 应用硅胶柱层析法分离和纯化, 波谱分析与已知化合物的波谱和理化性质比较得以确定化合物结构。结果 分离得到12个生物碱,其中4个为新生物碱, 命名为hemiargine A (1), B (5), C (6)D (7); 8个已知生物碱为isocorydine (2), corydine (3), norcorydine (4), salutari dine (8), glaucine (9), tetrahydropalmatrubine (10), xylopinoine (11)norlaudanosine (12)结论 获得4种新化合物,除生物碱( 8) ,其余生物碱均为首次从该属植物中获得。.

关键词: Croton hemiargyerius, 生物碱, hemiargine A,B,C和D

Abstract: Aim Investigation of alkaloids from the leaves of Brazilian medicinal plant Croton hemiargyerius var. gymnodiscus. Methods Silica gel column chromatography was used repeatedly for the isolation and purification, and their structures were identified by extensive spectroscopy and comparison of the chemical and physical data with those of authentic samples reported in literature. Results Twelve alkaloids were isolated and their structures were identified. Conclusion Four new alkaloids named hemiargines A (1), B (5), C (6) and D (7), together with eight known alkaloids namely isocorydine (2), corydine (3), norcorydine (4), salutaridine (8), glaucine (9), tetrahydropalmatrubine (10), xylopinoine (11), and norlaudanosine (12) were isolated.

Key words: Csroton hemiargyerius, Csroton hemiargyerius, new alkaloids, new alkaloids, hemiargines A,B,C,D, hemiargines A,B,C,D

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Supporting: *Corresponding author. Tel.: 010-62062210; fax: 010-82802724